1,275 research outputs found
Mood disorders in familial epilepsy: A test of shared etiology
No full textObjective: Mood disorders are the most common comorbid conditions in epilepsy but the cause remains unclear. One possible explanation is a shared genetic susceptibility to epilepsy and mood disorders. We tested this hypothesis by evaluating lifetime prevalence of mood disorders in relatives with and without epilepsy in families containing multiple individuals with epilepsy, and comparing the findings with rates from a general population sample.
Methods: The Composite International Diagnostic Interview was administered to 192 individuals from 60 families, including 110 participants with epilepsy of unknown cause (50 focal epilepsy [FE], 42 generalized epilepsy [GE], 6 FE and GE, 12 unclassifiable) and 82 relatives without epilepsy (RWOE). Odds ratios (ORs) for lifetime prevalence of mood disorders in participants with versus without epilepsy were computed through logistic regression, using generalized estimation equations to account for familial clustering. Standardized prevalence ratios (SPRs) were used to compare prevalence in family members with general population rates.
Results: Compared with RWOE, ORs for mood disorders were significantly increased in participants with FE (OR = 2.4, 95% confidence interval [CI] = 1.1 - 5.2) but not in those with GE (OR = 1.0, 95% CI = 0.4 - 2.2). In addition, prevalence of mood disorders was increased in individuals with epilepsy who had ≥1 relative with FE. Compared with general population rates, mood disorders were significantly increased in individuals with FE but not in those with GE. Rates were also increased in RWOE, but not significantly so (SPR = 1.4, P = 0.14).
Significance: These findings are consistent with the hypothesis of shared genetic susceptibility to epilepsy and mood disorders, but suggest (1) the effect may be restricted to FE, and (2) the shared genetic effect on risk of mood disorders and epilepsy may be restricted to individuals with epilepsy, that is, to those in whom the genetic risk for epilepsy is “penetrant.”Peer reviewedThis is the accepted version of the following article: Insel BJ, Ottman R, Heiman GA. Mood disorders in familial epilepsy: A test of shared etiology. Epilepsia. 2018;00:1–9. https://doi.org/10.1111/epi.13985, which has been published in the Early View form at http://onlinelibrary.wiley.com/doi/10.1111/epi.13985/full. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/author-resources/Journal-Authors/licensing-open-access/open-access/self-archiving.html]
Gas volume fraction and velocity profiles: vertical and inclined bubbly air-water flows
No full textUpward inclined gas-liquid flows are frequently encountered in the oil industry and data relating to the local gas volume fraction distribution and the local gas velocity distribution is important, for example, in pressure gradient prediction and in modeling oil well 'blowouts'. In this paper measurements are presented of the local gas volume fraction distribution and the local axial gas velocity distribution which were taken in bubbly air-water flows in an 80 mm diameter pipe which was inclined at angles of 0°, 15° and 30° to the vertical. Qualitative arguments are presented to explain the influence of the liquid superficial velocity on the local gas volume fraction distribution in inclined flow and also to explain the very high axial gas velocities observed towards the upper side of the inclined pipe
How "Chicagoan" are Gary Becker's Economic Models of Marriage?
No full textThis paper describes Gary Becker’s theoretical models of marriage. At the micro-level, these are all rational choice models. At the market level, Becker offers two major types of models: partial equilibrium models based on Price Theory as taught by Marshall and Friedman and optimal sorting models based on optimal assignment models. The paper examines some of the possible intellectual influences on Becker’s theory of marriage, compares Becker’s research on marriage with that of some scholars interested in intra-marriage distribution, and documents that Becker’s students at Chicago were more interested in Becker’s Friedmanian models of marriage than in his optimal assignment models.
Application of SSR markers in the construction of Australian barley genetic maps
No full textSimple sequence repeat (SSR) or microsatellite markers were examined for polymorphisms among the parents of 12 barley mapping populations. Of 259 SSRs screened, 149 were mapped on 1 or more of the 12 doubled haploid populations studied. The relative genetic positions of the 149 mapped SSR markers on Australian varieties are presented in the form of a consensus map. A database was created based on the results of screenings of barley varieties with a series of SSR markers. Details of the markers are at: http://www.scu.edu.au/research/ cpcg/Barley/index.php. A procedure is suggested for mapping new populations with microsatellites using this information and information available on other databases. These 12 populations have been mapped with SSR markers that act as 'anchors' for other types of genetic markers and for traits of interest. Some challenges in mapping SSRs were detailed. Multi-locus markers can cause confusion since one marker can map at different locations. Polymorphisms should be confirmed in new mapping varieties since some variation of allele size is seen in different sources of varieties of the same name, possibly due to differences in sources of germplasm. Lack of standardisation between laboratories or between analytical systems may also lead to differences in called allele sizes. SSRs proved to be adaptable to several technologies and economical, providing a preferred marker system for mapping new barley populations and to 'anchor' other types of markers.G. A. Ablett, A. Karakousis, L. Banbury, M. Cakir, T. A. Holton, P. Langridge and R. J. Henr
A citizen's guide to employment, inflation, income, and the Oregon economy
No full textR. Bruce Rettig, David R. Darr, Ludwig M. Eisgruber, John P. Farrell, A. Gene Nelson, Gary W. Sorenson.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Spread spectrum communications emulator design
No full textIssued as R & D status reports [nos. 1-4], Contract funds status reports [nos. 1-8], and Final report, Project no. E-21-T12Final report has author: Gary J. SaulnierFinal report has title: Spread spectrum communications emulator desig
Sequence polymorphisms in the flanking regions of microsatellite markers
No full textSNP markers may be discovered using many strategies. This chapter describes the approach of finding SNP markers in the flanking sequences surrounding microsatellites (simple sequence repeats (SSRs)). A major advantage of this strategy is that SSR markers have been widely studied and mapped in plant genomes, thus providing a readily available source of genetic loci that have already been mapped and that are readily convertible to SNP markers. SSRs have been markers of choice because they are highly informative, easy to use and many are now well-characterized. The topics covered include: SSR analysis; the main reasons for using SNP markers; the reason for using SSR markers to find SNPs; SNPs in wheat SSR markers; SNP discovery methods; pyrophosphate sequencing
Cyclical Persistence and the Cyclicality of R&D
No full textAbstract We propose cyclical persistence as an important factor in ‡uencing the link between short-run cycles and long-run growth, through the cyclicality of R&D. A simple theory is presented, suggesting that higher persistence can drive innovation pro-cyclical by raising the cyclicality of innovation's marginal expected return relative to that of its marginal opportunity cost. Our theory is carried to an industry panel of R&D and output. We …nd that cyclical persistence accounts for about half of the observed variation in industry R&D's cyclicality. The author thanks Wayne Gray and Randy Becker for their kindly providing the extended NBER manufacturing productivity databases, and Stephanie Yang for research assistance. Gary Richardson, Linda Cohen, Dan Bogart, Guillaume Rocheteau, Peter Rupert, Randy Wright, and seminar participants at the Atlanta Fed, USC, the Brookings Institutions, and the 2010 Midwest Macro Meeting provided helpful discussions. The remaining errors are mine
Recommended from our members
'A daughter come home?': the travel writings of Colleen J. McElroy
No full textBlack Industrial Noise, Ultima 2024
No full textPress Release from Ultima website:
"A radical ‘essay-concert’ reclaiming a post-colonial lineage of techno and noise. Black Industrial/Noise is an extended event taking over Henie Onstad Kunstsenter. Compelling experimental electronic music and noise artists and thinkers present a continuous flow of live music and talk, within a loosely defined concept of ‘Black Industrialism’.
Trevor Mathison and Gary Stewart have been in search of a black avantgarde since the 1980s. As the duo Dubmorphology they make experimental audio-visual installations and performances that examine the relationship between culture, history and creativity, reworking historical, political and scientific archives. Theorist and artist Kodwo Eshun is the author of the acclaimed book on music and Afrofuturism, More Brilliant Than the Sun (1998). He will give a performance-lecture outlining the aesthetic of Black Industrialism.
Nkisi is a producer, live musician, DJ and curator born in Congo, raised in Belgium. Her intense sonics are influenced by ancient Kongo rhythms, noise, the planetary electromagnetic grid, and experimental improvisation. South London’s Klein is an electronic composer with a Nigerian background. She specialises in grainy pop collages with R&B-inspired vocals, manipulated samples and metallic drones. As well as collaborating with Laurel Halo she has released music on the Hyperdub label and composed music for film.
- …
