8 research outputs found
Enhancement of the Supercapacitive Performance of Cobalt-tin-cyanate Layered Structures through Conversion from 2D Materials to 1D Nanofibers
No full textRational design of the micro-nanomorphology is highly desired for metal hydroxides to achieve overall high-performance electrodes for supercapacitor and energy storage applications. Here, in the current study, we have succeeded in controlling the morphology of Sn/Co nanolayered structures to obtain plate and nanofibrous morphologies. Additionally, the plate nanostructures could be transformed to obtain plate-nanofibrous morphologies. In this trend, dual anions such as cyanate and nitrate are applied to intercalate among the nanolayers of cobalt-tin and act as building blocks or pillars, producing a series of nanolayered structures. By repulsion forces among the intercalated anions, the nanolayers of Sn/Co are curled and converted to nanofibers. This conversion was confirmed by scanning electron microscopy. In addition, the intercalation reactions and nanolayered structures were indicated by X-ray diffraction, thermal analyses and Fourier-transform infrared spectroscopy. The electrochemical supercapacitive behavior of the different nanostructures of Sn/Co HDS and Sn/Co LDH, such as plate, Plate-nanofiber and nanofibrous morphology has been investigated in three assembly electrode system. The results suggested that the nanofiber morphology of Sn/Co LDH exhibited better specific capacitance performance than the other two morphologies. The enhanced specific capacitance (658 Fg−1) and excellent cyclic stability (89%) of the nanofibers of the Sn/Co LDH could be attributed to the synergistic effects between the electric double layer capacitive character of the tin and the pseudocapacitance nature of the cobalt
Case series: Using laryngeal mask airway to enhance the radiological evaluation and staging of cancers involving the larynx: A novel technique
No full textAbstract The diagnosis and staging of head and neck tumors requires proper clinical, endoscopic, and radiological evaluation. Currently, imaging techniques such as Magnetic Resonance Imagining (MRI) and Computed Tomography (CT) are used for head and neck tumors but are limited in showing involvement of different hypopharyngeal sub‐compartments. Several maneuvers have been developed to improve visualization of the head and neck area; however, they demonstrated minimal benefit. In this case series, patients with tumors involving the hypopharynx are studied. A laryngeal mask airway was used to stent the hypopharynx to assess the extent of the disease by creating real space between mucosal surfaces. This case series aims to describe the impact of using laryngeal mask airway on the evaluation of cancers involving the hypopharynx
Exploring the frontiers of transcriptomics: Methods, applications, and future perspectives
Get PDFBackground: By allowing for the thorough characterization of gene expression, transcriptomics—the study of RNA transcripts generated by the genome—has transformed molecular biology and biomedical research. This area of study offers vital insights into the functioning dynamics of biological systems, cellular mechanisms, and the course of disease. The speed of transcriptomics research has increased due to developments in high-throughput sequencing technologies, especially RNA sequencing (RNA-seq), which enables researchers to examine bulk and single-cell transcriptomes with previously unheard-of resolution. Our comprehension of transcriptome data in the larger framework of omics sciences is further improved by the incorporation of bioinformatics techniques. Aim: this study is to give a thorough introduction to transcriptomics, emphasizing its methods, uses, and difficulties. It also aims to draw attention to current developments in the subject and how they affect environmental sciences, health, and medicine. Methods: Results from peer-reviewed publications published between 2020 and 2024 are combined in this study. Together with bioinformatics tools for data processing, it critically evaluates transcriptome techniques such as RNA-seq, single-cell transcriptomics, and spatial transcriptomics. With an emphasis on integrated omics, applications in ecological studies, biotechnology, and disease research are examined. Findings: Transcriptomics has greatly improved our comprehension of intricate biological processes. 
Gas Sensing Performance of Zinc Oxide Nanoparticles Fabricated via <i>Ochradenus baccatus</i> Leaf
No full textZnO nanoparticles (NPs) were prepared by green synthesis using plant leaf extraction of Ochradenus baccatus and characterized by XRD, FESEM, HRTEM, and Raman spectroscopy techniques. Since elevated CO levels have been associated with inflammatory conditions, cardiovascular diseases, and respiratory disorders and the methane gas primarily produced by gut microbiota and linked to gastrointestinal disorders and other abnormal methane levels in breath samples, the nanoparticles were applied for gas sensor fabrication. Thus, the gas sensors fabricated using ZnO nanoparticles were investigated for CH4, H2, CO, and NO2 gases. The gas sensing was performed for the fabricated sensors at various operating temperatures and gas concentrations. Interestingly, leaf-extracted green synthesized ZnO NPs were more sensitive to CH4, CO, and NO2 gases than to H2. The results of sensing studies revealed that the nanoparticles exhibit a selectivity toward gas depending on the gas type. The sensor response was also studied against the humidity. These findings bridge between the laboratory and industry sectors for future gas sensors development, which can be used for exhaled breath analysis and serve as potential diagnostic tools for highly sensitive contagious diseases
Thrombophilia screening in clinical pathology: Guidelines and controversies
Get PDFBackground: Thrombophilia screening is crucial in assessing the risk of venous thromboembolism (VTE), particularly in patients with a history of VTE. Clinical guidelines recommend targeted testing based on management implications and clinical context, including factors like surgery, malignancy, and hormonal status. Aim: This review evaluates the significant laboratory factors affecting the interpretation of thrombophilia test outcomes, specifically focusing on inherited and acquired thrombophilias associated with VTE. Methods: The review discusses common thrombophilias, including factor V Leiden, prothrombin mutations, deficiencies in protein C, protein S, and antithrombin, as well as antiphospholipid antibodies. It emphasizes pre-analytical variables influencing diagnostic accuracy and describes recommended laboratory protocols for specimen collection, processing, and testing. Results: Key findings indicate that genetic mutations and deficiencies significantly elevate VTE risk in various populations. The accuracy of functional assays is influenced by factors such as specimen handling, anticoagulant therapy, and the presence of interfering substances. Conclusion: Proper interpretation of thrombophilia testing is essential for effective patient management. Understanding the impact of laboratory variables is crucial for minimizing diagnostic errors and ensuring accurate assessment of thrombotic risks
Additional file 2 of Whole‐exome sequencing of a Saudi epilepsy cohort reveals association signals in known and potentially novel loci
No full textAdditional file 2. Supplementary Table S2: identified 232 variants of unknown significance across 101 different genes in 133/144 (92%) subjects
Additional file 1 of Whole‐exome sequencing of a Saudi epilepsy cohort reveals association signals in known and potentially novel loci
No full textAdditional file 1. Supplementary Table S1: outlines additional minor allele frequencies in additional databases and further annotation of these putative pathogenic variants
The association between linagliptin and acute pancreatitis: A review
Get PDFBackgroundLinagliptin is a Dipeptidyl Peptidase inhibitor (DPP-4i) with rare hypoglycaemic episodes and no need for renal adjustment. However, acute pancreatic is a major concern.AimsThe current review aimed to assess the relationship between linagliptin and acute pancreatitis.Methods A systematic electronic search was conducted in PubMed, MEDLINE, and the first hundred articles of Google Scholar for relevant articles. All human studies published during the period from 2006 to October 2019 were eligible. Studies on animals, experimental studies, and reviews were excluded. The search terms linagliptin, acute pancreatitis, chronic pancreatitis, and DPP-4i with protean AND or OR were used One hundred and thirty-two articles were retrieved and only six met the inclusion and exclusion criteria. The author's name, country of origin, date of publication, type of study, number of patients, and the duration were reported.Results There were 132 studies (thirty-two in Pub Med and MEDLINE and the first hundred articles in Google Scholar), out of fourteen full texts reviewed, only six studies were eligible. Three were meta-analyses (showed no association of linagliptin with acute pancreatitis, a pooled analysis of 22 randomized controlled trials supported the above observation, while a recent randomized controlled trial concluded acute pancreatitis in 0.3 per cent in linagliptin arm vs. 0.1 per cent placebo of which 2/9 were fatal. The last study was a case report at a high risk of acute pancreatitis due to multiple gallstones and diuretics use.ConclusionAcute pancreatitis was not higher among linagliptin users. Physicians need to take the benefits of this weight and cardiovascular risk-neutral drug with no need for renal adjustment
