22,000 research outputs found
Gli psicofarmaci nei pazienti con cardiopatie.
No full textRegole pratiche nell'uso di psicofarmaci nei pazienti con problematiche cardiologiche di vario tipo
Monumenti e Culture nell' Appennino in età romana. Atti del convegno - Sestino (AR), 12 novembre 1989
No full textDelplace Christiane. Monumenti e Culture nell' Appennino in età romana. Atti del convegno - Sestino (AR), 12 novembre 1989. In: L'antiquité classique, Tome 64, 1995. pp. 558-559
Le Demenze
No full textManuale per l'insegnamento di Psichiatria nel Corso di Laurea di Medicina e Chirurgi
Risk factors for short-term mortality in older subjects with acute ischemic stroke.
No full textBACKGROUND: Stroke is the third cause of death in older individuals living in Western Countries. The identification of predictors for mortality after stroke has a major importance for clinicians in order to allow the implementation of therapeutic and preventive strategies. OBJECTIVE: To evaluate the association between clinical and laboratory parameters and 30-days total mortality in a large sample of older patients with stroke. METHODS: 469 older patients (median age: 80.0 years) consecutively hospitalized for acute ischemic stroke were enrolled. The data recorded included: (1) clinical features of stroke; (2) routine clinical chemistry analyses; (3) medical history, and (4) 12-lead ECG. All patients underwent computed tomography scan of the brain. Stroke type was classified by the Oxfordshire Community Stroke Project system. RESULTS: 130 subjects died within 30 days after stroke, with an overall mortality of 27.7%. At univariate analysis, altered levels of consciousness (ALC), congestive heart failure, atrial fibrillation, previous stroke, high blood glucose, fibrinogen and blood sedimentation rate levels, higher white blood cell count, lower serum albumin and iron levels were associated with mortality. Multivariate logistic regression analysis indicated that short-term mortality was associated with ALC (OR: 11.80; CI 95%: 5.50-24.00), congestive heart failure (OR: 3.06; CI 95%: 1.04-8.80), and age (OR: 1.04; CI 95%: 1.002-1.09) independent of gender, previous stroke, AF, fasting blood glucose, serum albumin, serum iron, and white blood cell count. In patients with ALC (high-mortality rate: 63.6%), only hyperglycemia (III vs. I tertile, OR: 9.60; CI 95%: 1.65-52.50) was associated with mortality after multivariate adjustment. CONCLUSION: Our study highlights the role of ALC and congestive heart failure in the short-term prognostic stratification of older patients with acute ischemic stroke. Furthermore, our results support the value of post-stroke hyperglycemia as a marker for short-term mortality also in advanced age, and particularly in the presence of ALC and in nondiabetic individuals
Cognitive complaints are associated to multi-morbidity in an old population with good cognitive functioning
No full textAntidepressant Therapeutic Drug Monitoring by Minimally Invasive Techniques in Eating Disorders Patients: Preliminary Results from a Pilot Study with Focus on Vortioxetine
No full textTherapeutic Drug Monitoring (TDM) is an evidence-based practice consistent with
the assumption that pharmacological plasmatic concentrations correlate better with
clinical effects than prescribed doses of the used drugs. TDM has several indications in
treated psychiatry patients: comorbidities, suspected non-compliance, severe adverse
effects and tailored pharmacotherapy. Antidepressant Drugs (AD) are prescribed in
patients with Eating Disorders (ED) to treat depression or anxiety disorders associated
with ED or to reduce binge-eating behaviours. TDM may represent a valid tool in this
population, considering the limited efficacy of ED’s pharmacological treatment and
the high rate of adverse effects. Nineteen outpatients affected by ED with a Body Mass
Index (BMI) < 20 or > 30 kg/m2 treated with antidepressants agreed to participate in
this study. Participants were treated with Sertraline (N=5), Fluoxetine (N=6), Vortioxetine
(N=4), Citalopram (N=2), Escitalopram (N=1), Fluvoxamine (N=1). Oral fluid samples and
whole blood dried microsamples by finger puncture using VAMS (Volumetric Absorptive
Microsampling) technique were obtained from patients. Sociodemographic and clinical
information were also collected
Factors associated with dementia in subjects with cerebrovascular disease
No full textThe pathogenesis of vascular dementia (VD) is still uncompletely understood. In the present study, we investigated a number of risk factors, including four common DNA polymorphisms that have been associated with cardiovascular disease and dementia, in a sample of 88 older subjects affected by cerebrovascular disease, with (VD: n = 68) or without (WD: n = 20) vascular dementia. The diagnosis of VD was based on the NINDS-AIREN criteria. All subjects with VD had a Hachinski ischemic score over 7. The functional status was measured by the Barthel index. Subjects with VD were characterized by older ages (82.5 ± 0.8, SEM and 75.6 ± 1.4, SEM), lower Barthel score (8.1 ± 0.8 and 13.7 ± 1.5), and fewer years of education (4.6 ± 0.4 and 6.6 ± 0.7) as compared to WD, respectively. The prevalence of cerebral atrophy (72 vs 53%), lacunar infarctions (75 vs 53%), and leukoaraiosis (50 vs 26%) was higher in VD, as compared to WD. On the contrary, the prevalence of cortical-subcortical ischemic lesion..
Psychotic symptoms and general health in a socially disadvantaged migrant community in Bologna
No full textBackground and aims. Several evidences showed that social exclusion and reduced access to primary care and mental health services can lead to urgent health problems among immigrants and can explain their increasing admittance to psychiatric in-patient units and high prevalence of psychotic disturbances. The present cross-sectional study aimed to evaluate general health status, distress and prevalence of psychotic symptoms among Romanian immigrants living in very poor conditions at a neglected hotel in Bologna. In Bologna as in Italy, Romanians are one of the largest immigrant communities. Methods. The Psychosis Screening Questionnaire and General Health Questionnaire-12 were administered to all Romanian immigrants residing at the hotel during two index days, with the help of a Romanian cultural mediator. Socio-demographic, migration and health characteristics were also collected. Results. 68 subjects were evaluated. More than 80% left Romania for economic reasons. 57% of immigrants surpassed the 4-point GHQ-12 threshold of potential mental disorders cases; 21% scored positively at the PSQ. The following factors were found to predict positive PSQ: being affected by chronic illness (OR=9.2, 95%CI=2.1–39.9); taking chronic drug therapy (OR=10.4; 95%CI=1.6–64.7); the development of new health problems after migrating (OR=8.8, 95%CI=2.0–38.3). Immigrants with positive PSQ showed higher mean GHQ-12 scores (5.9±3.5, vs. 3.8±2.75; p=0.02). Conclusions. This community of immigrants living in deprived conditions showed a very high prevalence of distress and psychotic symptoms, related with chronic health problems. More attention should be paid to physical and mental health of social disadvantaged immigrants
Beyond anorexia and bulimia nervosa: what's "new" in eating disorders?
No full textDespite the fact that awareness of eating disorders (EDs) has
grown during the past decades, the conceptualisation, psychopathological
characterisation and clinical diagnosis of EDs has
proven to be problematic for both researchers and clinicians.
Presently, diagnostic criteria employed for anorexia nervosa (AN)
and bulimia nervosa (BN) are unable to account for an exceedingly
high number of individuals with clinically significant eating
symptoms or to properly address new clinical prototypes of ED.
The aim of this paper is to describe the developments and current
limitations of EDs diagnoses, and to recapitulate the recent
literature on emerging phenotypes. Descriptions of the symptoms
and behaviours of ED patients with diabulimia, orthorexia, muscle
dysmorphia, drunkorexia and nocturnal eating disorders are
featured with special focus on psychopathological classification
and diagnostic ambiguity issues. An overview of non-specific eating
and feeding disorders (EDNOS) in the newly released DSM-5
eating and feeding disorders section is also provided. Given the
frequent transition between different phenotypes in patients with
EDs and the common occurrence of individuals with clinically
significant eating symptoms who evade diagnostic criteria, a better
understanding and categorization of emerging EDs is required
to guide psychiatric research and improve clinical outcomes
Anaemia increases the risk of dementia in cognitively intact elderly.
No full textAlthough cross-sectional studies found an association between anaemia and dementia, longitudinal studies provided contradictory results. We hypothesize that anaemia might increase the risk of developing dementia because of chronic brain hypo-oxygenation. Using baseline data from a community-based longitudinal study, the Kungsholmen Project, Stockholm, Sweden, we clinically followed 1435 non demented subjects aged 75-95 years for 3 years to detect incident dementia cases (DSM-III-R criteria). Subjects that fulfilled WHO criteria for anaemia, baseline haemoglobin concentration; 130 g/L (men) and 120 g/L (women), had a higher hazard ratios (HR) of developing dementia 3 years later (HR 1.6, 95% CI: 1.1-2.4). In persons with good baseline cognition (MMSE>or=26, n=1139), the association was stronger and still significant after adjustments for conditions potentially related to anaemia and dementia, such as chronic diseases, inflammatory markers, and indicators of nutritional status. The HR was increased even when different haemoglobin cut offs for anaemia definition were used. Thus, anaemia is suggested to be a new potential modifiable risk factor for dementia
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