1,721,074 research outputs found
CISTI SCROTALI MULTIPLE DI BLASCHKO E GUMPERT
No full textA case of multiple skin-coloured, dome-shaped or lobulated epidermoid cysts of varying sizes, localized in the scrotal and penile skin of a 43-year-old man, is reported. In the center of some of these, a pore-like opening was visible. The differential histological diagnosis between epidermoid and trichilemmal cysts is briefly discussed
Fine needle aspiration biopsy diagnosis of a bone metastasis from an occult carcinoma of the liver. A case report
No full textIn a 66-year-old male, fine needle aspiration biopsy (FNAB) of an osteolytic vertebral lesion determined the diagnosis of a liver cell carcinoma, until then clinically silent. FNAB confirmed the diagnosis of the tumor and the identification of the primary site without resorting to surgery
The association between non-Hodgkin lymphoma and renal cell carcinoma in an HIV-positive patient: Clinico-pathological features and pathogenic implications
No full textCentral nervous system tissue heterotopia of the nose: case report and review of the literature.
No full textThe authors present a case of heterotopic central nervous system tissue observed in an 81-year-old male in the form of an ethmoidal polyp. A review of the literature indicates that this is a rare condition characterised by a connective tissue lesion with astrocytic and oligodendrocytic glial cells, which may be located outside the nasal pyramid in some cases and inside the nasal cavity in others. The most important diagnostic aspect involves differentiating these from meningoencephalocele, which maintains an anatomical connection with central nervous system tissue. Contrast-enhanced imaging is essential for diagnosis, as in cases of heterotopic central nervous system tissue, it will demonstrate that there are no connections with intra-cranial tissue. Endoscopic excision is the treatment of choice
Concurrent thymic stroma sarcoma (thymoliposarcoma) and breast carcinoma. Report of a case
No full textA case of sarcoma of thymic stroma with features of liposarcoma associated with breast carcinoma is presented. No previous reference was found in the literature to this association. It is possible that this event could be not entirely fortuitous but an element sustaining the pathogenetic theory relating stromal and epithelial neoplasias in the thymus
Anaplastic lymphoma kinase-positive large B-cell lymphoma: Description of a case with an unexpected clinical outcome
No full textAnaplastic lymphoma kinase-positive (ALK-positive) large B-cell lymphoma is a rare and aggressive variant of large B-cell lymphoma (LBCL), first reported by Delsol et al in 1997, showing distinctive morphologic, immunophenotypic and cytogenetic features. The latest 2008 World Health Organization Classification of Tumours of Haematopoietic and Lymphoid tissues recognizes ALK-positive LBCL as a separate entity. Here, we report a case of ALK-positive large B-cell lymphoma in a 53-year-old man with diffuse abdominal and mediastinal lymph-nodes involvement. According to the Ann Arbor staging system, the patient had a stage IIIB lymphoma. The age-adjusted International Prognostic Index was 2 (stage III and elevated lactate dehydrogenase), so the disease was considered high risk. The patient underwent chemotherapy, radiotherapy, and an autologous stem cell transplantation. The patient is alive and free of disease 35 months after diagnosi
Microdose alpha-interferon shows clinical and antiangiogenic effect in extramedullary myeloid tumor: a case report.
No full textextramedullary myeloid tumors (EMMT) are peculiar neoplasm that derive from myeloid progenitors, onset as solid masses in different tissues, involving bone marrow and peripheral blood only at the latest stages on progression. INcrease of angiogenesis has been described in myeloproliferative disorders whereas no data are available in EMMT. Alpha-interferon has been reported to be an antiangiogenic agent with clinical efficacy in few cases of solid tumors
Immunohistochemical surrogates for genetic alterations of CCDN1, PML, ALK, and NPM1 genes in lymphomas and acute myeloid leukemia.
No full textThe World Health Organization (WHO) classification of lympho-hemopoietic neoplasms is increasingly based on genetic criteria. Detection of tumor-associated primary genetic lesions is usually performed using the polymerase chain reaction (PCR) and/or fluorescence in-situ hybridization (FISH). This review focuses on alternative techniques for detecting genetic lesions in biopsy samples. Immunohistochemical surrogates for the detection of genetic alterations involving the CCND1, PML, anaplastic lymphoma kinase (ALK) and nucleophosmin (NPM1) genes are presented as examples for this approach. Because of their high specificity, rapidity, low costs and ease of performance, these assays have the potential for being extensively applied in developing countries. In some instances (e.g. detection of ALK protein) immunohistochemistry has fully replaced molecular studies for routine diagnosis in paraffin-embedded specimens. Genome wide based discovery of new tumor-associated genetic lesions that are suitable for antibody targeting promises to further expand the application of immunohistochemistry for the molecular classification of hematological neoplasms
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