1,721,236 research outputs found

    Quantification of adrenergic nerve fibers in human thymus at various ages

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    Adrenergic nerve fibers were studied in human thymus at various ages by biochemical and morphological methods and by quantitative analysis of images. The whole thymus was harvested during autopsies in prenatal of six months (n=6), newborn (n=6), infant (n=3), young (n=3), adult (n=3) and elderly (n=3) men. The thymuses were weighed, dissected and studied. Thymic slices were subjected to specific staining for the detection of microanatomical details regarding thymic microenvironment and nerve fibers. Histofluorescence microscopy was used for staining of adrenergic nerve fibers, while immunofluorescence microscopy was employed for staining of neuropeptide Y-like immunoreactivity. Biochemical dosage of proteins and of noradrenaline amount was performed. All morphological results were subjected to the quantitative analysis of images. Our results confirmed that many changes occur with age in the whole weight of the thymus and in thymic protein content and, as a new finding, demonstrated the specific pattern of three independent markers able to characterize sympathetic nerve fibers of the human thymus and its modifications with age: neuropeptide Y-related staining decreases with age, whereas the density of adrenergic nerve fibers remains unchanged. The apparent discrepancy among these three independent markers for sympathetic nerves was discussed. (author abst.

    290 surgical procedures for ulnar nerve entrapment at elbow: physiopathology, clinical experience and results.

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    Ulnar nerve entrapment at the elbow is an important and relatively frequent pathological condition that may be related to different causes depending on individual or external factors. The cause of the nerve lesion is also idiopathic in about one-quarter to one-third of cases. This variable aetiopathogenetic presentation has often suggested different diagnostic and clinical approaches and, moreover, various surgical procedures. We present our 8-years surgical experience with 290 cases of ulnar nerve entrapment at the elbow analysing the salient clinical features and the results of the surgical treatment in the light of the relevant literature available on this topic

    Benign Neural Sheath Tumours of Major Nerves: Characteristics in119 Surgical Cases

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    Peripheral benign nerve sheath tumours are infrequent tumours and affect major nerve trunks. Some authors have indicated a high and prohibitive incidence of neurological injury in resection of these lesions. The authors describe their findings in a retrospective study comprising 119 patients with spontaneous benign nerve sheath tumours of the peripheral nervous system. Seventy-three patients had a schwannoma, 41 had neurofibroma and 5 had plexiform neurofibroma; 25 of the 119 patients suffered from neurofibromatosis. All schwannomas were excised completely and the outcome of patients was 41.0% improved, 6.8% worsened, 52.0% unchanged. Twenty-eight neurofibromas were excised completely and 13 subtotally; the outcome for patients was 19.5% improved, 19.5% worsened and 61% unchanged. All plexiform neurofibromas were removed subtotally and the outcome for patients was 20% improved and 80% unchanged. The best surgical results at average follow-up of 6 years were observed in the patients with schwannoma, the worst in those with plexiform neurofibroma. Our results demonstrated that it is often possible to remove schwannomas as well as neurofibromas with an acceptable risk of injury to the nerve
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