1,720,970 research outputs found
DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children
No full textAssociation between DEFB1 gene polymorphisms and HIV infectio
Copy number variation of defensin genes and HIV infection in Brazilian children
No full textEvaluation of Copy Number Variations in HIV positive patients. Identification of a new susceptibility gene
Association between HLA-G 3'UTR 14-bp polymorphism and HIV vertical transmission in Brazilian children
No full textHLA-G polymorphisms analysis in HIV childre
Association between MBL2 polymorphism and T1D: does ethnicity play a role in the susceptibility of this multifactorial disease?
No full textPolymorphisms in DC-SIGN and L-SIGN genes are associated with HIV-1 vertical transmission in a Northeastern Brazilian population.
No full textDC-SIGN and L-SIGN are receptors expressed on specialized macrophages in decidua, (Hofbauer and placental capillary endothelial cells), known to interact with several pathogens, including HIV-1. To disclose the possible involvement of these molecules in the susceptibility to HIV vertical transmission, we analyzed DC-SIGN and L-SIGN gene single nucleotide polymorphisms (SNPs) in 192 HIV-1 positive children and 58 HIV-1 negative children all born to HIV-1 positive mothers, as well as 96 healthy uninfected children not exposed to HIV-1, all from Northeast Brazil. The frequency of three SNPs in the DC-SIGN promoter (-139G>A, -201G>T and -336A>G) were significantly different when comparing HIV positive children with HIV-1 exposed uninfected children, indicating an association with susceptibility to HIV-1 vertical transmission. This genetic association suggests that DC-SIGN molecule may play a role in susceptibility to HIV-1 infection through vertical transmission
Rapid Genetic Screening for major HLA risk haplotypes in patients with type 1 diabetes from North East Brazil
No full textIL-18 gene promoter polymorphism is involved in HIV-1 infection in a Brazilian pediatric population
No full textMBL2 functional allelic variants and increased risk for the development of atopic dermatitis in Brazilian children.
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