1,721,001 research outputs found
XPS CHARACTERIZATION OF PDMS BASED MICROFLUIDIC CHANNELS OF CLINICAL APPLICATION TREATED WITH DIFFERENT SOLVENTS
No full textRiassunti / absract presentati al XXV Congresso della Divisione di Chimica Analitica della Società Chimica Italian
PDMS Treated by Dichloromethane: Swollen Weight without Underestimation Due to the Solvent Volatility and Thermal Aging to Reduce Swelling and Morphology Damage
No full textFast and safe microwave-assisted glass channel-shaped microstructure fabrication
No full textGlass micromachining is a basic technology to achieve microfluidic networks for lab-on-a-chip applications. Among several methods to microstructure glass, the simplest and most widely applied is wet chemical etching (WE). However, accurate control of the reaction conditions to perform reproducible, fast and safe glass etching is not straightforward. Herein, microwave-assisted WE is demonstrated to intensify the glass etching action under safe working and finely monitored operative conditions and to produce smooth deep channels in short processing times with reduced underetching effects
Fabrication of interconnected multilevel channels in a monolithic SU-8 structure using a LOR sacrificial layer
No full textThe development of new microfabrication techniques is attracting more and more interest because of the increasing demand for three-dimensional tools with features of biocompatibility, flexibility and low-costs in the lab-on-chip field. Photolithographic techniques involving the molding of organic polymers, like SU-8, allow for short fabrication times and simplicity in devices prototyping. In this paper we used LOR and SU-8 resists in combination within an innovative lithographic approach. LOR resist was employed not as a typical sacrificial layer for the production of free-standing structures but as a three-dimensional solid resist, which can be patterned and embedded in a SU-8 monolith. After dissolution it can form cavities to provide a final multilevel structure. A detailed description of the optimization process required to obtain the final structure and to overcome issues related to the employ of LOR is reported. In the end, a network of working interconnected multilevel microchannels, useful for biological applications, has been realized through a new, cheap and time-saving method
Free-standing micropatternable nanocomposites as efficient colour converting filters for light emitting devices
No full textOne step preparation of quantum dot-embedded lipid nanovesicles by a microfluidic device
No full textSynthetic carriers that mimic "natural lipid-based vesicles" (such as micro/nanovesicles, exosomes) have found broad applications in biomedicine for the delivery of biomolecules and drugs. Remarkable advantages of using synthetic carriers include control over the lipid composition, structure and size, together with the possibility to add tracer molecules to monitor their in situ distribution via fluorescence microscopy. Over the past few years, new methods of vesicles production have been developed and optimized, such as those based on microfluidic techniques. These innovative approaches allow us to overcome the limitations faced in conventional methods of liposome preparation, such as size distribution and polydispersity. Herein, a Microfluidic Hydrodynamic Focusing (MHF) device has been used for the production of lipid-based vesicles with different lipid combinations that resemble natural exosomes, such as phosphatidylcholines (PC), cholesterol (Chol), dicetyl phosphate (DCP) and ceramide (Cer). Thanks to a fine control on fluid manipulation, the MHF device allows preparation of vesicles with controlled size, a relevant feature in the emerging field of carrier-assisted cell-delivery. Interestingly, PC/Chol/Cer vesicles exhibit low polydispersity and high stability up to 45 days. Later, quantum dots (QDs) were successfully embedded in these vesicles through the same preparation process. The development of QD-embedded lipid nanovesicles by MHF devices has never been described previously
Cyclic olefin copolymer (COC) as a promising biomaterial for affecting bacterial colonization: investigation on Vibrio campbellii
No full textRandom laser emission from a paper-based device
No full textRandom laser emission is obtained from a fluidic paper-based device realized by conventional soft-lithography techniques on common, flexible, renewable and biocompatible commercial paper. The device is realized exclusively on paper by creating microfluidic porous channels on the cellulose fibres, in which a laser dye (Rhodamine B) can flow by capillarity. The modulation of the random lasing characteristics, in terms of threshold and spectral position, can be tailored by acting on the confinement induced by the lithographic process as well as on the shape and functionalization at the interface of the emitting regions
Non-Biofouling Fluorinated Block Copolymer Coatings for Contact Lenses
No full textFilms of two fluorinated block copolymers (P(S81-Sz6) and P(S81-Sz11)) were investigated and compared with those of a commercial Teflon-like polymer (PTFE-AF) in the search for novel non-biofouling coatings able to minimize the amount of tear fluid (TF) proteins absorbed on contact lens (CL) surfaces. The adsorption of a solution containing lysozyme, albumin and immunoglobulin G (mimicking the TF composition) on the fluorinated block copolymers was evaluated using a quartz crystal microbalance. P(S81-Sz11) was found to resist protein adsorption more effectively than P(S81-Sz6) and PTFE-AF. The different interaction of P(S81-Sz6) and P(S81-Sz11) with the artificial TF was attributed to creation of a more heterogeneous and moderately hydrophobic surface of the latter polymer film by dynamic contact angle and atomic force microscopy studies. Moreover, deposition of P(S81-Sz11) on a CL-like silicone (PDMS) and a CL thin films demonstrated a protein adsorption reduction of up to 70% relative to pristine PDMS and commercial CL thin films
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