1,721,250 research outputs found
Perforation of muscle shelf of right coronary cusp causing acute regurgitation of porcine mitral xenograft.
No full textI. F. 2008: 4.28
My Parents Died of Myocardial Infarction: Is that My Destiny?
No full textThis article presents an overview of clinical and molecular genetics of myocardial infarction (MI). Discussion includes the partial overlapping of risk factors for myocardial infarction and atherosclerosis, the impact of a positive family history on the risk of MI, the " familial" nongenetic, environmental factors, the inherited risk associated with the low-dose input of many genes, and a simple approach to stratify the individual risk in genetic counseling
Risk of acute postoperative hypertension after topical photodynamic therapy for non-melanoma skin cancer
No full textBackground: Topical photodynamic therapy with methyl aminolevulinate (MAL-PDT) is a non-surgical treatment for actinic keratoses, Bowen's disease and basal cell carcinoma. MAL-PDT is particularly useful in elderly patients, who often present co-morbidities and/or in whom surgical excision could be contraindicated. MAL-PDT is generally well tolerated; the most frequent acute adverse events include pain and burning sensation localized to the treatment area. We describe our observation of the occurrence of acute postoperative hypertension (APH) and hypertensive crisis, after a MAL-PDT. Methods: BP measurement was taken twice at 2-min intervals, both before and shortly after the MAL-PDT session. APH was defined as an increase in systolic BP by more than 20% or an increase in diastolic BP to above 110mmHg. Hypertensive crisis was defined as a systolic BP ≥180mmHg or a diastolic BP ≥110mmHg, with or without acute target organ involvement. Results: Prevalence of post-MAL-PDT APH was 22%; 11% of patients developed hypertensive crisis after MAL-PDT, requiring immediate treatment. Conclusion: We highlight the importance of blood pressure measurement both before and after MAL-PDT session to identify high-risk patients and to prevent potentially severe organ involvement subsequent to hypertensive crisis
PERTINET- PERindoopril-thrombosis, Inflammation, endothelial dysfunction and neurohormonal activation trial: A sub-study of the EUROPA study
No full textA new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) IB and severely reduced amounts of GPIX and GPV.
No full textWe describe a new variant of Bernard-Soulier syndrome characterized by almost normal amounts of GPIb and severely reduced GPIX and GPV. Despite surface expression, GPIbalpha failed to support ristocetin-induced platelet agglutination and to bind two conformation-dependent monoclonal antibodies, suggesting a qualitative defect. Sequence analysis of the gene coding for GPIX revealed a T-to-C substitution at base 1811, leading to a Leu40Pro conversion, whereas no defects were found in the coding region of the GPIbalpha gene. Allele-specific restriction enzyme analysis showed that the propositus and one of his sisters. both with severe bleeding diathesis. were homozygous for the GPIX mutation: the members of the family with mild bleeding diathesis and/or giant platelets in the peripheral blood were heterozygous, whereas the healthy ones were homozygous for the normal allele. Infusion of 1-desamino-8-D-arginine vasopressin normalized bleeding time in the two severely affected patients, although it did not modify ristocetin-induced platelet agglutination or membrane expression of GPIbalpha, GPIX, GPIIb-IIIa and GMP-140. Moreover, in one patient, normalization of bleeding time and rise of von Willebrand factor plasma concentration did not seem to be directly related
Cell density modulates SHC3 expression and survival of human glioblastoma cells through Fak activation.
No full text
Detection of Epstein Barr virus in formalin-fixed paraffin tissues by fluorescent direct in situ PCR
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