101,941 research outputs found
L'iloprost nel trattamento dei pazienti con ischemia critica cronica (C.L.I.): la nostra esperienza
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Molecular markers della coagulazione e fibrinolisi nelle arteriopatie periferiche aterosclerotiche
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Accuratezza dell'ecografia doppler nella diagnosi di stenosi dell'arteria renale (vs angiografia)
No full textCOMPARISON BETWEEN THE EFFECT OF L-PROPIONYLCARNITINE, L-ACETYLCARNITINE AND NITROGLYCERIN IN CHRONIC PERIPHERAL ARTERIAL-DISEASE - A HEMODYNAMIC DOUBLE-BLIND ECHO-DOPPLER STUDY
No full textThe haemodynamic effects on the peripheral vascular bed of L-acetylcarnitine, L-propionylcarnitine, and nitroglycerin were tested by echo-Doppler in a double blind cross-over study. Eleven male patients suffering from peripheral arterial obliterative disease (PAOD) in the second stage of Fontaine's classification, and 11 matched control subjects were enrolled in the study. Each subject received one of three different treatments on each day of the study in a different order following a random assignment. The treatments were either 30 mg x kg of L-acetylcarnitine (LAC) or 30 mg x kg of L-propionylcarnitine (LPC) or nitroglycerin (NTG) 1.25 mg given as a single i.v. bolus injected over 3 min. Echo-Doppler measurements of blood flow velocity, and cross-sectional area of the femoral artery were performed at baseline and 10, 20, and 30 min after injection the drugs. Pulsatility Index (an index derived from the blood flow velocity and related to vascular resistance: PI = Vmax - Vmin/Vmean) was also obtained each time. Results were analysed using a Student's t-test for paired data. L-acetylcarnitine and L-propionylcarnitine showed no haemodynamic effects in either group of subjects (controls and PAOD patients) whether blood flow or vascular resistance was considered. There were haemodynamic changes ( a decrease in blood flow velocity and an increase in arterial systemic resistance) only after NTG administration. The changes were more evident in controls than in PAOD patients. Femoral artery cross-sectional area showed no statistically significant effect as regards treatment. In conclusion, echo-Doppler flowmetry correctly assessed haemodynamic changes determined by the administration of NTG, whereas no changes were observed after LAC or LPC injection. Improvements in walking capacity after administration of these drugs could ony be related to metabolic effects
Alteration of membrane transductive mechanisms induced by ethanol in human lymphocyte cultures.
No full textEthanol, in millimolar concentrations, significantly modifies different transductive systems in human lymphocyte cultures. In particular, the presence of alcohol in the medium more than doubles the [Ca2+]i (from 70-90 to 200-250 nM), increasing Ca2+ fluxes from outside, and inhibits the active transport carried out by the calcium pump. The Ca2+ release from intracellular stores is not involved because 10 mM EGTA in the medium completely abolished the rise of [Ca2+]i. Since IP3 levels and cAMP concentrations are also involved in ethanol events (although with opposite effects), it seems that the alcohol may have a specific target on cell membranes (G-proteins) which influence many transductive pathways
Hemodynamic effects of propranolol, octreotide, and their combination during fasting and post-prandial splanchnic hyperaemia in cirrhotic patients
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