1,721,080 research outputs found
Riabilitazione implanto-protesica in area estetica in un paziente parodontalmente compromesso
No full textLa funzionalizzazione immediata degli impianti postestrattivi: studio clinico ed istologico
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Effetti clinici e microbiologici di un chip di clorexidina sottogengivale a rilascio controllato nel trattamento della parodontite: studio multicentrico
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A multidisciplinary approach to a complex case of a failed implant in the aesthetic area.
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Effetto mitogeno dei derivati della matrice dello smalto (EMD) su cellule staminali mesenchimali umane (MSC)
No full textThe Effect of Titanium Surface Modifications on Dental Implant Osseointegration
No full textThe use of titanium dental implants has consistently changed the way of rehabilitating patients in modern dentistry and can count on high long-term survival and success rates. With respect to its introduction in the late 1960s, clinical indications for implant therapy have been significantly extended and optimal results have been achieved, even in clinical conditions formerly considered as unfavourable. Such evolution owes a lot to the significant progress made in the field of titanium surfaces. The topographical and chemical modification of traditional titanium surfaces has led to a real epochal shift in implant dentistry. Depending on the type and characteristics of the surface treatment applied, a wide range of implants has been produced, which have contributed to the success but also increased the risk of confusion in implant selection criteria for the clinician. This chapter, which provides an updated analysis of the relevant literature, the characteristics of modern implant surfaces, the biological principles underlying their role in promoting osseointegration and the scientific evidence about their clinical use are analyzed and presented.The use of titanium dental implants has consistently changed the way of rehabilitating patients in modern dentistry and can count on high long-term survival and success rates. With respect to its introduction in the late 1960s, clinical indications for implant therapy have been significantly extended and optimal results have been achieved, even in clinical conditions formerly considered as unfavourable. Such evolution owes a lot to the significant progress made in the field of titanium surfaces. The topographical and chemical modification of traditional titanium surfaces has led to a real epochal shift in implant dentistry. Depending on the type and characteristics of the surface treatment applied, a wide range of implants has been produced, which have contributed to the success but also increased the risk of confusion in implant selection criteria for the clinician. This chapter, which provides an updated analysis of the relevant literature, the characteristics of modern implant surfaces, the biological principles underlying their role in promoting osseointegration and the scientific evidence about their clinical use are analyzed and presented
The response of bone marrow stromal cells to differently treated titanium surfaces
No full textObjectives: The aim of this study was to evaluate the effect of differently treated titanium implant surfaces on the response of human bone marrow stromal cells (BMSCs) in terms of adhesion, proliferation and osteogenic differentiation.
Methods: 15x1 mm titanium disks machined (M), pellet-blasted (P), sand-blasted (S), titanium-nitride sandblasted (TiN-S), titanium plasma sprayed (TPS) and titanium-nitride TPS (TiN-TPS) (P.H.I. s.r.l., San Vittore Olona, Milano, Italy) were topographically examined by atomic force microscopy and confocal optical profilometry. Primary cultures of BMSCs, obtained from bone marrow samples of healthy donors, were seeded on the titanium disks and cell adhesion and proliferation were evaluated. Furthermore, the osteogenic differentiation, in terms of alkaline phosphatase activity, osteocalcin synthesis and extracellular mineralization, was also analysed.
Results: Implant surfaces showed different roughness (Sa) values (M ≤ P < S ≤ TiN-S << TiN-TPS < TPS) ranging from 0.3 to 6 μm. Cell adhesion was enhanced by rough surfaces with respect to machined ones, whereas the proliferation remained unmodified and the osteogenic parameters were reduced. No difference was found between S and TiN-S disks as well as between TPS and TiN-TPS in terms of any of the examined parameters.
Conclusions: Our results evidenced that the surface roughing treatments seem to enhance the adhesion of BMSCs onto titanium implant surfaces, but not their differentiation toward the osteoblastic phenotype. Furthermore, the additive process of TiN-coating, usually applied to improve the physico-chemical properties of implant surfaces, did not alter their biological performance compared to the respective uncoated samples
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