171,879 research outputs found
Esperienza clinica in presidio medico avanzato (PMA), nell’emergenza sisma di L’Aquila: studio osservazionale.
No full textAdsorption of 4-(N,N-Dimethylamino)-4′-nitrostilbene on an Amorphous Silica Glass Surface
No full textStilbenes are a compelling class of organic photoswitches with a high degree of tunability that sensitively depend on their environment. In this study, we investigate the adsorption properties of 4-(N,N-dimethylamino)-4′-nitrostilbene (DANS), a push-pull stilbene, on amorphous silica glass. Plane-wave density functional theory (DFT) calculations are used to understand how the trans and cis isomers of DANS interact with the amorphous surface and which are the most preferred modes of adsorption. Our calculations revealed that the O-H···O hydrogen bonds between the nitro group and hydroxyl groups of the silica surface dominate the intramolecular interaction. In addition to hydrogen bonding, O-H···π interactions with the aromatic ring and double bond play a critical role in adsorption, whereas C-H···O interactions are present, but contribute little. Therefore, both isomers of DANS favor parallel orientations such that not only the functional groups but also the aromatic parts can strongly interact with the glass surface
Diffusion and Coalescence of Phosphorene Monovacancies Studied Using High-Dimensional Neural Network Potentials
No full textThe properties of two-dimensional materials are strongly affected by defects that are often present in considerable numbers. In this study, we investigate the diffusion and coalescence of monovacancies in phosphorene using molecular dynamics (MD) simulations accelerated by high-dimensional neural network potentials. Trained and validated with reference data obtained with density functional theory (DFT), such surrogate models provide the accuracy of DFT at a much lower cost, enabling simulations on time scales that far exceed those of first-principles MD. Our microsecond long simulations reveal that monovacancies are highly mobile and move predominantly in the zigzag rather than armchair direction, consistent with the energy barriers of the underlying hopping mechanisms. In further simulations, we find that monovacancies merge into energetically more stable and less mobile divacancies following different routes that may involve metastable intermediates
INTUBAZIONE DIFFICILE IMPREVISTA GLIDESCOPE VS INTRODUTTORE ENDOTRACHEALE DI FROVA STUDIO PROSPETTICO RANDOMIZZATO
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Bradykinin B2 receptor antagonist off label use in short-term prophylaxis in hereditary angioedema
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Clinical challenges in the management of cancer pain: the breakthrough/episodic pain (BT/EP) part one.
No full textGlidescope videolaryngoscopy vs Frova endotracheal introducer in difficult unexpected airway management
No full textBackground and Goal of Study: In unpredicted difficult orotracheal intuba- tion (OTI), both national and international guidelines suggest to avoiding more than three attempts in order to reduce the risk of “cannot intubate - cannot ventilate” situation. The second attempt should be performed with some mod- ified elements such as laryngoscope blades, position of the patient’s head, BURP, etc., but the third one should be performed using alternative devices. The guidelines don’t provide any precise indications about videolaryngo- scopes as alternative to fibrobroncoscopy. The aim of this study is comparing the ef ficacy of the Frova and Glidescope in the unpredicted dif ficult OTI in pa-
tients admit ted to elective inter ventions and the evaluation of stress
by the maneuver per formed using the t wo devices, through hemodynamic monitoring.
Materials and methods: A randomized controlled trial was performed on 40 consecutive patients, through the ages of 18 to 70, under general anesthe- sia with more than one attempts of the OTI maneuver. A Frova Introducer or Glidescope were used while comparing the duration of the first attempt to the duration of the OTI using Frova Introducer or Glidescope. Cardiorespira- tory monitoring predicted the registration of the following parameters: BP, HR, SaO2 and EtCO2,at T0= before induction;T1=before direct laryngoscopy with a Macintosh laryngoscope,T2=during direct laryngoscopy,T3= OTI with Frova or Glidescope,T4=10 minutes later.
Results and discussion: There were 40 randomized consecutive patients with unpredicted dif ficult OTI in the Frova group (FI) (n=20) and in the Glides- cope group (GS) (n=20).Most of the patients of both groups were intubated at the first attempt using Frova (n=13) patients and patients with Glide (n=12); the rest of the patients at the second attempt. The overall time needed for the correct placement of the endotracheal tube was significantly briefer (P< 0.001) in the FI group (12.1±4.1 sec) compared to the GS group (39.9±11.8 sec). Monitoring BP and HR in various times has shown a significant increase in both groups corresponding to T2 and T3 (P < 0.001) corresponding to direct laryngoscopyConclusions: All patients in this study were successfully intubated; already in the first attempt with Frova or Glidescope in most cases. The SaO2 values were always above the security levels (< 97%). The OTI with Frova was faster and less traumatic compared to the one with glidescop
Duloxetine and Pregabalin for Pain Management in Multiple Rheumatic Diseases Associated with Fibromyalgia
No full text"The fibromyalgia syndrome (FMS) is characterized by chronic and widespread musculoskeletal pain and soreness accompanied by sleep disorders, chronic fatigue and affective disorders. FMS is often associated with other forms of immuno-rheumatic diseases. Although FMS pathophysiology is still not fully understood, a number of neuroendocrine, neurotransmission and neurosensitive disorders might generate a mechanism for the elicitation of pain by "central sensitization," which is common to many other painful conditions. The present case describes the success of a therapeutic scheme, which associates two different pharmacological classes, anticonvulsants and new-generation antidepressants, when FMS complicates a rare pathology called Cogan's syndrome. The association of two drugs might noticeably affect the molecular mechanisms of difficult pain, thus solving painful conditions of multifactorial origin."The fibromyalgia syndrome (FMS) is characterized by chronic and widespread musculoskeletal pain and soreness accompanied by sleep disorders, chronic fatigue and affective disorders. FMS is often associated with other forms of immuno-rheumatic diseases. Although FMS pathophysiology is still not fully understood, a number of neuroendocrine, neurotransmission and neurosensitive disorders might generate a mechanism for the elicitation of pain by "central sensitization," which is common to many other painful conditions. The present case describes the success of a therapeutic scheme, which associates two different pharmacological classes, anticonvulsants and new-generation antidepressants, when FMS complicates a rare pathology called Cogan's syndrome. The association of two drugs might noticeably affect the molecular mechanisms of difficult pain, thus solving painful conditions of multifactorial origin. © 2012 World Institute of Pain
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