1,257 research outputs found
"Systematisch benachteiligt" [Interview mit der brasilianischen Politikwissenschafterin Malu Gatto, von Andrea Müller]
No full textSchweizer Frauen seien systematisch benachteiligt von der Politik, sagt die brasilianische Politikwissenschafterin Malu Gatto. Sie fordert Geschlechterquoten – mit gutem Grund
The wronskian and its derivatives
Get PDFArticolo testo di una conferenza tenuta presso l'Accademia Peloritana dei Pericolanti (Messina
Translation. The State of the Art/ La Traduzione. Lo Stato dell'Arte
No full textThe volume includes chapters by eminent scholars in the field of linguistics and translation studies (Michaela Mahlberg, Federico Zanettin, Federica Scarpa, Sara Laviosa, as well as contributions by younger scholars from the University of Bari. Maristella Gatto is co-editor as weel as author of the chapter "Da paesaggi aspri a rugged scenery: la rete come corpus e il linguaggio del turismo
In-/off-label use of biologic therapy in systemic lupus erythematosus
Get PDFCurrent therapies for systemic lupus erythematosus (SLE) include corticosteroids as a persistent mainstay and traditional immunosuppressants which are given according to disease severity, organ involvement and patient status. No treatment entails certain efficacy devoid of mild-to-moderate adverse effects. Nowadays, novel therapies are being developed aiming to target specific molecules involved in SLE development and progression which show variable effectiveness and safety. Biologic agents considered for SLE comprise monoclonal antibodies (chimeric, humanized or fully human) as well as fusion molecules or antibody fragments mostly consisting of B cell-targeted therapies beside anti-cytokines as well as T cell-targeted therapies. Encouraging evidence on biologics is mostly provided by case series or uncontrolled studies; conversely, larger randomized controlled clinical trials have frequently missed their primary endpoints with the exception of BLISS-52 and BLISS-76 trials. Actually, apart from belimumab, biologics are employed in clinical practice as off-label treatments for lupus and results are often promising, depending on specific SLE features, dose regimens and individual responsiveness. © 2014 Gatto et al.; licensee BioMed Central Ltd
Critical Evaluation of Indentation Fracture Toughness Measurements with Vickers Indenter on Ceramic Matrix Composite Tools
No full textThe evaluation of fracture toughness of advanced ceramic matrix composites (CMC) may be expensive if performed using conventional techniques (notch, long and short pre-cracks methods using the three or four point bending fracture test). The use of cracking during the indentation technique is ideally suited for toughness evaluation on a comparative basis and its result appears to provide a method for classifying CMC tools, according to their potential, as cutting tool materials having both high hardness and good crack resistance.The mechanism that leads to the higher fracture toughness of the composite are not yet fully understood. A number of toughening mechanisms such as crack deflection, crack branching, whiskers pullout, bridging (governed by interracial properties), and microcracking have been suggested in the literature, but there is still an ongoing debate about the relative importance of each of these mechanisms. Some authors believe that crack deflection is the main toughening mechanism: it occurs in materials containing anisotropically shaped grains or reinforcements. Crack deflection results when a crack front interacts with a second phase and changes its propagation direction, altering the fracture mode from pure mode I. Other authors suggest that in the crack wake bridging zone, whisker pull out is the major contributor in toughening.In this paper, the effective weight of indentation size effect (ISE), post indentation slow crack growth, material anisotropy and toughening mechanisms are critically evaluated.The CMC tools investigated were: SiCw/Al2O3; TiC/Al2O3; ZrO2/Al2O3. The fracture toughness measurements were performed considering the total crack length (summing all cracks visible on the surface) and the results were compared with those obtained in accordance with the Japanese Industrial Standard JIS R 1607
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