1,721,082 research outputs found
Inhibition of PPARγ by Natural Compounds as a Promising Strategy in Obesity and Diabetes
Full text linkA wide group of natural compounds (flavonoids, stilbenes, neolignans and others) has been identified as Peroxisome Proliferator-Activated Receptor (PPAR) agonists, with a large variety of chemical structure and different activity versus the three PPAR subtypes. These receptors are transcription factors controlling metabolic pathways in the organism, involved in lipid and glucose metabolism, cell differentiation and energy homeostasis. Otherwise, very little is known about natural compounds able to inhibit PPARs. A number of studies demonstrate that PPARγ repression has a beneficial effect in reducing body weight and improving insulin sensitivity, suggesting a potential clinical role in obesity and type 2 diabetes. This review analyzes natural compounds able to repress PPAR activity and their potential use in metabolic disorders. © 2019 Ammazzalorso and Amoroso
Amidine-Based Bioactive Compounds for the Regulation of Arginine Metabolism
No full textIn the research of new bioactive compounds able to regulate the L-arginine metabolism, several substituted amidines were disclosed as potent and selective inhibitors of mainly three enzyme families: the nitric oxide synthase, the dimethylarginine dimethylaminohydrolase and the peptidylarginine deiminase. The present work is focused on the last five years developments in the research for amidine-based inhibitors of the mentioned enzymes and on their potential usefulness in neurodegenerative, inflammatory and autoimmune disorders. - See more at: http://www.eurekaselect.com/111524/article#sthash.tUTGinTF.dpu
Synthesis of chiral a-substituted β-amino acids starting from 6-alkylperihydropyrimidin-4-ones
No full textSintesi di L e D-β-amminoacidi attraverso la formazione intermedia di amidali otticamente attivi
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