630 research outputs found
The emerging role of follicular CD4 T cells in the immune system: a comprehensive analysis in different diseases and anatomic compartment in the era of Covid19
No full textT follicular helper cells (TFH) are specialized subset of CD4 + T cells essential for the proper generation of germinal center (GC) reaction which eventually lead to the development of antigen specific memory B cell upon antigen stimulation. The present dissertation will perform a comprehensive analysis of the emerging role of TFH in the immune system analyzing their role in different diseases and anatomic compartment with a focus on SARS-CoV2. Only few studies in humans were able to provide a discrete description of the complex network of cytokines, chemokines and lymphocytes acting in tissues after antigenic challenge since most data derive from animal models. A better understanding of the biology of human immune system within tissues, where the actual immune responses take place, is mandatory to fill the gap of knowledge between animal and human models and to gain more insight into the basic immunology. I report published results of TFH analysis performed across the PhD course, starting with the analysis of mucosal immune dynamics in tonsils investigating the spatial positioning, frequency, and phenotype of immune cells after vaccination. Next, the increasing evidence of the active role of TFH also in the context of immunodeficiencies led us to further investigate their role in such condition. In this context I report a detailed immunophenotyped 6 analysis of children affected by Chromosome 22q11.2 deletion syndrome. Finally the emergence of SARS-Cov2 pandemic pushed the scientific community and ourselves in concentrating the efforts to dissecting the pathogenesis of this disease. I report the results of an important study about the immunology of Multisystem Inflammatory Syndrome in Children with COVID-1
Chemical, physical and sensorial characterization of fresh quinoa sprouts (Chenopodium quinoa Willd.) and effects of modified atmosphere packaging on quality during cold storage
No full textThe aim of this study was the quality characterization and the evaluation of the storage potential of “Real” and ‘Regalona Baer’ quinoa sprouts. Sprouting characteristics, texture, sensorial and chemical proprieties were evaluated on sprouts after 4 days of imbibitions and during storage in a passive modified atmosphere packaging (MAP). ‘Regalona Baer’ showed higher germination and weight increase, higher phenolic content and sensorial properties than ‘Real’. ‘Real’ sprouts also showed the shortest shelf life, whereas ‘Regalona Baer’ sprouts were still marketable after 7 days. A separate experiment was performed to study the effects of passive and active MAP with 5% O2 + 20% CO2 on the ‘Regalona Baer’ variety. Sprouts stored in active MAP showed a better texture and a minor production of off-flavor, compared to samples stored in passive MAP, thus showing for the first time that active packaging with 5% O2 + 20% CO2 may be a potential solution for allowing the distribution of this product
Document on the royal appointment of Donato in the Regimiento de Fixo de la Louisiana.to subteniente of infantry.
No full textDocument on the royal appointment of Donato in the Regimiento de Fixo de la Louisiana.to subteniente of infantry
Document on the royal appointment to subteniente of infantry for Donato in the Regimiento de Fixo de la Louisiana.
No full textDocument on the royal appointment to subteniente of infantry for Donato in the Regimiento de Fixo de la Louisiana
Chemical, physical and sensorial characterization of fresh quinoa sprouts (Chenopodium quinoa Willd.) and effects of modified atmosphere packaging (MAP) on quality during cold storage
No full textThe Role of Insects in Medical Engineering and Bionics: Towards Entomomedical Engineering
No full textInsects are important agents in ecosystems. Their diverseness and developed coping mechanisms also make them interesting for direct application and as a source of inspiration in medical engineering. We summarized the main contribution of insects in biomedical applications. Medical centers in North America, and Europe use fly larvae for maggot therapy to remove necrotic tissue, decrease infection risk, and improve wound healing. Ant mandibles are used as a suturing technique by African tribes and as sources of inspiration for surgical clamps. Both the mosquito fascicle and the wasp ovipositor are sources of inspiration for the design of medical needles. Herein, a new research field called 'entomomedical engineering,' is proposed. We define entomomedical engineering as the branch of engineering that uses insects either directly or as a source of inspiration to design and develop medical treatments or instruments. In addition, we want to emphasize the importance of preserving insects because of their function in the ecosystem, medicine, and medical engineering. Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Medical Instruments & Bio-Inspired Technolog
Author Correction: Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons (Nature Communications, (2019), 10, 1, (662), 10.1038/s41467-019-08607-1)
No full text© 2019, The Author(s). The original version of this Article contained an error in the spelling of the author J. Donato Jr, which was incorrectly given as Donato J. Jr. This has now been corrected in both the PDF and HTML versions of the Article
Characters in Search of an Author. Unfolding the territorial governance of Italian Metropolitan Cities.
No full textL'abstract è presente nell'allegato / the abstract is in the attachmen
Pereira, l’ordine delle cose e la legge di Hume
No full textThe author discusses some remarks by Paolo Comanducci about his book L'ordine naturale delle cose. Particularly, he defends the idea of a strict connection between principle of equality, role of statutes and legal interpretation and asserts the importance of the humanities in ethics, politics and legal thought
Atti di indirizzo politico-amministrativo, risultati amministrativi, valutazione discrezionale degli organi amministrativi nella Regione Campania
No full textThe article summarises the research carried out by the Author at the University of Sannio in
the academic year 2018/2019 on the topic “Public Administration: Simplifying decision-mak-
ing processes, improving performance” under the supervision of Professor PierPaolo Forte
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