1,721,040 research outputs found
Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma.
Full text linkHepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized
by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on
which cancer develops. Inflammation and the consequent fibro/cirrhosis, derived from chronic injuries of
several origins (viral, toxic and metabolic) and observable in almost all oncological patients, represents the
most powerful risk factor for HCC and, at the same time, an important obstacle to the efficacy of systemic
therapy. Multiple microenvironmental cues, indeed, play a pivotal role in the pathogenesis, evolution and
recurrence of HCC as well as in the resistance to standard therapies observed in most of patients. The
identification of altered pathways in cancer cells and of microenvironmental changes, strictly connected in
pathogenic feedback loop, may permit to plan new therapeutic approaches targeting tumor cells and their
permissive microenvironment, simultaneousl
Il fegato: la sfida dell'ingegneria tissutale di epiteli complessi
No full textmondadori università - Minerva sagg
"Epigenetic Regulation in Hepatocellular Carcinoma Requires Long Noncoding RNAs"
Full text linkRecent evidence has proven the relevance of epigenetic changes in the development of hepatocellular carcinoma (HCC), the major adult liver malignancy. Moreover, HCC onset and progression correlates with the deregulation of several long non-coding RNAs (lncRNAs), exhibiting great biological significance. As discussed in this review, many of these transcripts are able to specifically act as tumor suppressors or oncogenes by means of their role as molecular platforms. Indeed, these lncRNAs are able to bind and recruit epigenetic modifiers on specific genomic loci, ultimately resulting in regulation of the gene expression relevant in cancer development.
The evidence presented in this review highlights that lncRNAs-mediated epigenetic regulation should be taken into account for potential targeted therapeutic approaches
National and international patent: “Genetically modified non human mammal cells procedure of their production and use in toxic tests” 14/08/2002. International extension 15/02/2006.
No full textIDENTIFICAZIONE DI UN PRECURSORE BIPOTENZIALE IN LINEE CELLULARI EPATOCITARIE (MMH) DERIVATE DA TOPI TRANSGENICI PER CYTO-MET.
No full text"MOLECULAR MECHANISM CONTROLLING EMT/MET OSCILLATIONS AND HEPATOCYTE DIFFERENTIATION OF RESIDENT LIVER STEM CELLS (RLSCS)".
No full textSelected presentation from submitted (poster) abstracts
Molecular Mechanisms controlling EMT/MET oscillations and hepatocyte differentiation of Resident Liver Stem Cells (RLSC)
No full text
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