198,448 research outputs found
LBP and lower limb discrepancy: 3D evaluation of postural rebalancing via underfoot wedge correction
No full textAMICO galaxy clusters in KiDS-DR3: Weak lensing mass calibration
No full textWe present the mass calibration for galaxy clusters detected with the AMICO code in KiDS DR3 data. The cluster sample comprises 7000 objects and covers the redshift range 0.1 < z < 0.6. We perform a weak lensing stacked analysis by binning the clusters according to redshift and two different mass proxies provided by AMICO, namely the amplitude A (measure of galaxy abundance through an optimal filter) and the richness λ∗ (sum of membership probabilities in a consistent radial and magnitude range across redshift). For each bin, we model the data as a truncated NFW profile plus a two-halo term, taking into account uncertainties related to concentration and miscentring. From the retrieved estimates of the mean halo masses, we construct the A-M200 and the λ∗-M200 relations. The relations extend over more than 1 order of magnitude in mass, down to M200 ∼ 2 (5) × 1013 M h−1 at z = 0.2 (0.5), with small evolution in redshift. The logarithmic slope is 2.0 for the A-mass relation, and 1.7 for the λ∗-mass relation, consistent with previous estimations on mock catalogues and coherent with the different nature of the two observables
AMICO-COSMOS galaxy cluster and group catalogue up to
No full textAims. We present the results of a new galaxy cluster search in the COSMOS field obtained using the Adaptive Matched Identifier of Clustered Objects (AMICO). Our aim was to produce a new cluster and group catalogue up to z = 2 by performing an innovative application of AMICO with respect to previous successful applications to wide-field surveys in terms of depth (down to r < 26.7), small area covered (∼1.69 deg2 of unmasked effective area), and redshift extent. This sample and the comparative analysis we performed with the X-rays, allowed for the calibration of mass-proxy scaling relations up to z = 2 and down to less than 1013 M⊙, and constitutes the basis for the refinement of the cluster model for future applications of AMICO, such as the analysis of upcoming Euclid data.
Methods. The AMICO algorithm is based on an optimal linear matched filter and detects clusters in photometric galaxy catalogues using galaxy location, photometric redshift and, in the simplest case, one galaxy property. We chose to use a single magnitude as the galaxy property, avoiding the explicit use of galaxy colour for the selection of clusters. We used three different magnitudes by performing three independent runs in the r-, Y-, and H-bands using both COSMOS2020 and COSMOS2015 galaxy catalogues. We created a composite visibility mask and cluster models for the signal to detect, and we estimated the noise directly from the data.
Results. We performed a matching of the catalogues resulting from the three runs and merged them to produce a final catalogue that contains 1269 and 666 candidate clusters and groups with S/N > 3.0 and > 3.5, respectively. A total of 490 candidates are detected in all three runs. Most of the detections unmatched between runs have S/N < 3.5, which can be set as a threshold for selecting a more robust sample. We assigned X-ray properties to our detections by matching the catalogue with a public X-ray selected group sample and by estimating, for unmatched detections, the X-ray properties at the location of AMICO candidates using Chandra+XMM-Newton data. There are in total 622 candidate clusters and groups with an X-ray flux estimate. This large sample of candidates with X-ray properties allowed the calibration of the scaling relations between two AMICO mass-proxies (richness and cluster amplitude) and X-ray mass and the study of their redshift dependence for the selection of the most stable photometric bands
Withdrawal contractures of guinea-pig isolated ileum after acute activation of kappa-opioid receptors.
No full text1. The present study was undertaken to investigate firstly whether a brief exposure for 5 min of guinea-pig isolated ileum to the kappa-opioid agonist, U-50,488H produced a withdrawal contracture on addition of naloxone and secondly to ascertain whether the response was due to the activation of kappa-opioid receptors. 2. Naloxone (10(-6) M) did not elicit a response in preparations exposed to U-50,488H (5 x 10(-7) M-2 x 10(-6) M). However, after exposure to U-50,488H (5 x 10(-7) M), naloxone (10(-6) M) produced a strong contracture if the agonist was washed out 1 min before the addition of the antagonist. 3. The addition of naloxone (10(-6) M) to the ileum preparation exposed to U-50,488H (10(-7) M or lower) caused a response of similar intensity irrespective of whether the agonist had been washed out. 4. The selective kappa-opioid antagonist, nor-binaltorphimine (2.7 x 10(-9) M and 2.7 x 10(-7) M), injected before the opioid agonists, prevented the naloxone-induced contracture after exposure to U-50,488H (8 x 10(-8) M) but did not affect the contracture after exposure to morphine (5 x 10(-7) M). 5. Nor-binaltorphimine (2.7 x 10(-9) M) caused a contraction of the ileum preparation when injected 5 min after exposure to U-50,488H (8 x 10(-8) M) but not after morphine (5 x 10(-7) M). 6. The alpha 2-adrenoceptor agonist, clonidine (3 x 10-8 M) and the calcium channel blocker, nifedipine(3 x 10-8 M), injected 1 min before naloxone, blocked the ileum contraction to naloxone after exposure to U-50,488H (8 x 10-8 M). The results demonstrate that the stimulation of Kappa-opioid receptors can induce a similar dependence in guinea-pig ileum to that produced by activation of micro receptors
Acute withdrawal after bremazocine and the interaction between mu- and kappa-opioid receptors in isolated gut tissues.
No full text1. This study was undertaken to investigate whether, after a brief exposure of guinea-pig isolated ileum and rabbit jejunum to bremazocine, a kappa-opioid agonist also possessing antagonist activity at mu-opioid receptors, the addition of opioid antagonists produced withdrawal contractures. Our aim was to verify in these tissues the existence of an interaction between the mu- and kappa-opioid systems. 2. In guinea-pig ileum preparations previously exposed for 5 min to bremazocine at 5.7 x 10(-7) M and 5.7 x 10(-8) M, naloxone (5 x 10(-7) M) elicited no response whereas in tissues exposed to a lower bremazocine concentration (5.7 x 10(-9) M), naloxone (5 x 10(-7) M) and the selective kappa-opioid antagonist, nor-binaltorphimine (3.4 x 10(-8) M) both produced a strong contracture. 3. Bremazocine (5.7 x 10(-7) M) administered to guinea-pig isolated ileum, previously exposed for 5 min to morphine (10(-7) M), induced a withdrawal contracture. In contrast, lower bremazocine concentrations (1.4 and 7.1 x 10(-8) M) did not elicit a withdrawal contracture. 4. Naloxone (5 x 10(-7) M), added to the bath after a 5 min exposure of guinea-pig ileum to morphine (10(-7) M), elicited the characteristic withdrawal contracture. Bremazocine (1.4-7.1 x 10(-8) M) added 1 min before naloxone (5 x 10(-7) M) inhibited the naloxone withdrawal contracture in a dose-related way whereas naloxone 5 x 10(-8) M added 1 min before naloxone 5 x 10(-7) M, did not affect the withdrawal response. 5. In the rabbit jejunum, bremazocine (1.4-7.1 x 10-8 M) caused a decrease in amplitude in the spontaneous tissue activity. In tissues exposed to these bremazocine concentrations, naloxone(5 x 10-7 M) elicited a marked contracture. A similar contracture occurred when nor-binaltorphimine(3.4 x 10-8 M) was added in place of naloxone. These effects were dose-related to the bremazocine concentration. The specific K-agonist, U-50,488H (5 x 10-8 M), elicited the same effects as bremazocine.6. These findings show that stimulation of K-opioid receptors induces a state of dependence that is not prevented by blocking the pi-opioid system. The observation that low bremazocine concentrations inhibit the morphine-induced withdrawal contractures, indicates an interaction between the micro- and K-opioid system in guinea-pig isolated ileum, similar to that observed in the whole animal
How political choices shaped Covid connectivity: The Italian case study
No full textThe importance of implementing new methodologies to study the ever-increasing amount of Covid-19 data is apparent. The aftermath analysis of these data could inform us on how specific political decisions influenced the dynamics of the pandemic outbreak. In this paper we use the Italian outbreak as a case study, to study six different Covid indicators collected in twenty Italian regions. We define a new object, the Covidome, to investigate the network of functional Covid interactions between regions. We analyzed the Italian Covidome over the course of 2020, and found that Covid connectivity between regions follows a sharp North-South community gradient. Furthermore, we explored the Covidome dynamics and individuated differences in regional Covid connectivity between the first and second waves of the pandemic. These differences can be associated to the two different lockdown strategies adopted for the first and the second wave from the Italian government. Finally, we explored to what extent Covid connectivity was associated with the Italian geographical network, and found that Central regions were more tied to the structural constraints than Northern or Southern regions in the spread of the virus. We hope that this approach will be useful in gaining new insights on how political choices shaped Covid dynamics across nations
Ioannis Baptistae Amici Cosentini de motibus corporum coelestiu[m] iuxta principia peripatetica sine eccentricis & epicyclis
No full text[Giovanni Battista Amico]Kolophon: Impressi Venetiis a Ioanne Patavino & Venturino RoffinelloExlibrisetikette: "Libreria Antiquaria Mediolanum Via Montebello, 24 Milano" 990108669740205503_0001 Exemplar der ETH-BI
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