13 research outputs found
m17-1A-, c17-1A- and cSF25-mediated antibody-dependent cell-mediated cytotoxicity in patients with advanced cancer
No full textAchieving abdominal closure following emergency laparotomy in patients with connective tissue disorders
No full textInterleukin 1 and tumour necrosis factor alpha may be responsible for the lytic mechanism during anti-tumour antibody-dependent cell-mediated cytotoxicity
No full text
Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer
No full textThis international study aimed to test the measurement properties of the updated European Organisation for Research and Treatment of Cancer (EORTC) questionnaire module
for colorectal cancer, the QLQ-CR29. The QLQ-CR29 was administered with the QLQ-C30, core questionnaire, to 351 patients from seven countries. Questionnaire scaling and reliability were established and clinical and psychometric validity examined. Patient acceptability and understanding were
assessed with a debriefing questionnaire. Multi-trait scaling analyses and face validity refined the module to four scales assessing urinary frequency, faecal seepage, stool consistency and body image and single items assessing other common problems following treatment for colorectal cancer. Scales distinguished between clinically distinct groups of patients and did not correlate with QLQ-C30 scales, demonstrating construct validity. The QLQ-CR29 scores were reproducible over time
in stable health
Reporting of long-term survival and oncological outcomes of colorectal cancer surgery: A systematic review
No full textA systematic review of outcome reporting in colorectal cancer surgery.
No full textAIM: Evaluation of surgery for colorectal cancer (CRC) is necessary to inform clinical decision-making and healthcare policy. The standards of outcome reporting after CRC surgery have not previously been considered. METHOD: Systematic literature searches identified randomized and nonrandomized prospective studies reporting clinical outcomes of CRC surgery. Outcomes were listed verbatim, categorized into broad groups (outcome domains) and examined for a definition (an appropriate textual explanation or a supporting citation). Outcome reporting was considered inconsistent if results of the outcome specified in the methods were not reported. Outcome reporting was compared between randomized and nonrandomized studies. RESULTS: Of 5644 abstracts, 194 articles (34 randomized and 160 nonrandomized studies) were included reporting 766 different clinical outcomes, categorized into seven domains. A mean of 14 ± 8 individual outcomes were reported per study. 'Anastomotic leak', 'overall survival' and 'wound infection' were the three most frequently reported outcomes in 72, 60 and 44 (37.1%, 30.9% and 22.7%) studies, respectively, and no single outcome was reported in every publication. Outcome definitions were significantly more often provided in randomized studies than in nonrandomized studies (19.0% vs 14.9%, P = 0.015). One-hundred and twenty-seven (65.5%) papers reported results of all outcomes specified in the methods (randomized studies, n = 21, 61.5%; nonrandomized studies, n = 106, 66.2%; P = 0.617). CONCLUSION: Outcome reporting in CRC surgery lacks consistency and method. Improved standards of outcome measurement are recommended to permit data synthesis and transparent cross-study comparisons
I Remember Me:Mnemonic Self-Reference Effects in Preschool Children
No full textIt is well established that children recognize themselves in mirrors by the end of infancy, showing awareness of the self as an object in the environment. However, the cognitive impact of objective self-awareness requires further elucidation. This gap in the literature is addressed in a series of 7 experiments exploring the role of self in 3- and 4-year-olds' event memory. A mnemonic bias for self-relevant material has been described in adults. This effect is thought to be based on the organizational properties of a highly elaborated self-concept, and so offers a clear route to study the child's developing sense of self. However, very few studies have investigated the ontogeny of this effect. New evidence is provided to suggest that preschool children, like adults, show a mnemonic advantage for material that has been physically linked with the self through performance of a depicted action (Experiment 1). Moreover, 3- and 4-year olds show a bias for material that has been visually and linguistically processed with the self-image (Experiments 2, 3, 4), and material that has been socio-cognitively linked to the self in terms of ownership (Experiments 5, 6, 7). The data imply that both bottom-up (kinesthetic feedback, self-concept) and top-down (attention) aspects of self reflection may play a supporting role in early event memory, perhaps representing a nascent form of autobiographical processing. Importantly, this research highlights a promising methodology for elucidating the executive role of the self in cognition. Following William James's (1890) influential conception of the self, it seems that in typical development, "I" is primed to remember "me.
Synthesis and summary of patient-reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery.
No full textAim: Patient reported outcome measures (PROMs) are standard in the assessment of colorectal cancer (CRC) treatment, but the range and complexity of available PROMs may be hindering evidence synthesis. This systematic review aimed to 1) summarise PROMs in studies of CRC surgery and 2) categorise PRO content to inform the future development of an agreed minimum 'core' outcome set to be measured in all trials. Method: All PROMs were identified from a systematic review of prospective CRC surgical studies. The type and frequency of PROMs in each study were summarized, and numbers of items documented. All items were extracted and independently categorized by content by two researchers into 'health domains' and discrepancies discussed with a patient and expert. Domain popularity and distribution of items were summarized. Results: 58 different PROMs were identified from the 104 included studies. There were 23 generic, 4 cancer specific, 11 disease and 16 symptom specific questionnaires, and 3 ad hoc measures. The most frequently used PROM was the EORTC QLQ-C30 (50 studies), and most PROMs (40,69%) were used in only one study. Detailed examination of the 50 available measures identified 917 items, which were categorized into 51 domains. The domains comprising the most items were 'anxiety' (n=85,9.2%), 'fatigue' (n=67,7.3%), and 'physical function' (n=63,6.9%). No domains were included in all PROMs Conclusion: There is major heterogeneity of PRO measurement and wide variation in content assessed by PROMs available for CRC. A core outcome set will improve PRO outcome measurement and reporting in CRC trials
The phonological development of adult Japanese learners of English : a longitudinal study of perception and production.
No full textSIGLEAvailable from British Library Document Supply Centre-DSC:DXN042757 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
