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Continuous combined HRT in post-menopause: two regimen comparative study
Continuous combined HRT in post-menopause: two regimen comparative study U. Omodei,
F. Sorgi, A. Torri and AM Boccuti Department of Obstetrics and Gynecology, University of
Brescia, Italy Introduction A large body of evidence has accumulated concerning the positive
benefits of estrogen treatment, including a decreased incidence of osteoporosis, vasomotor
symptomathology, and relative risk of chardiovascular disease (CHD)
Premarin 0.625 vs Estraderm TTS 50 Have These Two" Standard Doses" the Same Biological Effects?
A New HRT Regimen Using Estradiol Valerate and Cyproterone Acetate: Impact on Lipid Metabolism
We evaluated a new sequential HRT regimen (Climen‐Schering) consisting of a
combination of estradiol valerate (2 mg, days 1‐11) and cyproterone acetate (CPA: 1 mg)
plus estradiol valerate (2 mg, days 12‐21) followed by a 7‐day interval with no drug intake.
The interesting aspect of this regimen is the use of CPA. a strong progestogen with
antiandrogenic properties. For this reason, CPA is expected not to counteract the favourable
estrogen impact on lipids
A New HRT Regimen Using Estradiol Valerate and Cyproterone Acetate: Clinical Data
A new sequential HRT regimen (Climen‐Schering) consisting of a combination of estradiol
valerate (EV)(2 mg. days 1‐11) and cyproterone acetate (CPA; 1 mg) plus EV (2 mg, days 12‐
21) followed by a 7‐day drug‐free interval was tested, The interesting aspect of this regimen
is the use of CPA, a strong progestogen with antiandrogenic properties
Doppler flow evaluation of endometrial conditions in postmenopausal breast cancer patients treated with tamoxifen
The aim of the study was to evaluate the usefulness of Doppler flow
ultrasonography in the evaluation of 88 postmenopausal breast cancer patients treated with
tamoxifen (20 mg/day for at least 1 year). Twenty healthy postmenopausal women served as
controls. The PI and RI (mean+/-SD) in the tamoxifen group (1, 77+/-0, 47 and 0, 79+/-0, 1,
respectively) were significantly lower than those of the control group (2, 64+/-0, 8 and 0, 92+/-
0, 1, respectively)
Endometrial changes in postmenopausal breast cancer patients receiving tamoxifen: a transvaginal ultrasound study
Abstract: The purpose of the study was to evaluate the effects of tamoxifen therapy on the
endometrium by transvaginal sonography. Seventy-nine asymptomatic postmenopausal
women treated with tamoxifen (20 mg/day) for at least one year were recruited. Twenty
healthy postmenopausal women served as controls. All patients underwent transvaginal
ultrasound to evaluate endometrial thickness and echotexture
Endometrial ultrasound transvaginal (TVU) assessment in postmenopausal women on hormone replacement therapy (HRT)
There are only fragmentary data about TVU assessment in postmenopausal
women on HRT, but usually an endometrial thickness (ET)< 4mm (as for postmenopausal
women not on HRT) seems adequate to exclude the presence of endometrial pathology.
The aim of our study was to evaluate the TVU effectiveness compared with hysteroscopy
(HSG) plus endometrial biopsy to identify endometrial alterations, and to find a cut-off value
under which invasive techniques are useless
The effect of HRT on uterine arterial blood flow in postmenopausal women assessed by transvaginal color doppler sonography (TVDS)
HRT has been suggested to have neither a metabolic nor a direct vascular effect
on arterial tone. PI and RI are indicators of resistance to flow: the higher the value of these
indices, the greater the resistance to flow. The TVDS measurements of uterine blood flow in
postmenopausal women (pmw) show a mean uterine artery PI of 3.3+/-1.04 and a mean RI
of 0.93+/-0.1. The aim of our study was to determine whether HRT had any positive effect on
uterine arterial blood flow. 96 pmw consented to enter the study
The Effect of HRT on Endometrial Thickness (ET) and Uterine Arterial Blood Flow Assessed by Transvaginal Ultrasound (TVU).
The aim of our study was to evaluate the TVU effectiveness compared to hysteroscopy plus
endometrial biopsy (HS/B) to identity endometrial alterations and to find a cut‐off value
under which invasive techniques are useless; furthermore, we aimed to determine whether
HRT had any positive effect on uterine arterial blood flow, 96 postmenopausal women
(pmw) consented to enter the study. Patients*(pts) mean age was 56.1 years. with
menopausal amenorrhoea for at least 9 months and on HRT for at least 6 month
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