1,721,454 research outputs found
Serum and bile biomarkers for cholangiocarcinoma.
No full textAbstract
PURPOSE OF REVIEW: To discuss recent studies proposing new markers in serum or bile for the diagnosis and prognosis of cholangiocarcinoma (CCA), which could help in the differential diagnosis between malignant and benign biliary disorders or for the surveillance of disorders at risk, including primitive sclerosing cholangitis.
RECENT FINDINGS: In the last few years, efforts have been made to identify biomarkers with adequate diagnostic accuracy for CCA in serum or biological fluid. Studies have been focused on cytokines, growth factors or enzymes produced and secreted by CCA cells as well as on the proteomic analysis of serum and bile.
SUMMARY: The serum levels of interleukin 6, trypsinogen, mucin-5AC, soluble fragment of cytokeratin 19 and the platelet-lymphocyte ratio have been recently shown to help in the diagnosis of CCA with, in some cases, a prognostic value. As far as bile is concerned, the ratio of pancreatic elastase/amylase, mucin-4, minichromosome maintenance replication protein and insulin-like growth factor 1 have been explored, with the insulin-like growth factor 1 biliary concentration capable of completely discriminating CCA from benign biliary disorders and pancreatic cancer. We have also discussed advances in the proteomic of serum and bile, which seem promising in identifying new markers for CCA
Biliary epithelium: a new chapter in cell biology
No full textThe intrahepatic biliary epithelium lines the biliary tree from the duct of Hering to the extrahepatic bile ducts. Until the early '90's, the biliary tree was considered to play only a mechanic role in trasporting bile into the duodenum. In he last few years, a number of experimental models have generated a bulk of new knowledge showing holy the biliary epithelium displays extraordinary properties in term of secretion, absorption, proliferation and signalling toward the other liver parenchymal and mesenchymal cells. It is now clearly emerging that the functions of biliary epithelium are tightly regulated by a number of hormones and neuropeptites. This heralds a number of novelties not only from a physiologic point of view but also in terms of pathology and pharmacological management of the diseases targeting the intrahepatic biliary epithelium. The aim of this manuscript is to revise recent knowledge on cell biology of the biliary epithelium
The challenge of cholangiocarcinoma diagnosis: the turning point is in extracellular vesicles?
No full text
Gallstones: Bad Company for the Steatotic Liver
Full text linkGallstones are very frequent worldwide with a prevalence ranging from 10% to 15% in Western countries to <5% in Africa, with the geographic variations being associated with genetic and environmental factors.1 Although asymptomatic in more than 80% of patients, gallstone disease incurs one of the highest health care costs among digestive diseases and hospitalization is frequent as a consequence of its complications
Le Malattie delle vie biliari
No full textL’albero biliare è un sistema di dotti di diametro progressivamente
crescente dai dotti di Hering fino ai dotti biliari extraepatici (Fig. 1).
I dotti biliari sono rivestiti dai colangiociti, che svolgono un ruolo
fondamentale nel modificare la bile formata dagli epatociti e nel determinare
la composizione finale della bile che arriva in duodeno. Le
malattie che coinvolgono il sistema dei dotti biliari si chiamano colangiopatie
e sono state classificate come sindromi da vanificazione dei
dotti biliari (Tab. I). Tale nome deriva dal fatto che le colangiopatie
sono caratterizzate dalla scomparsa (vanificazione) dei dotti biliari
intraepatici che porta alla duttupenia, definita sul piano anatomo-patologico
come assenza dei dotti biliari interlobulari in più del 50% degli
spazi portali. Gli altri elementi patologici comuni a tutte le sindromi
da vanificazione dei dotti biliari sono la proliferazione dei dotti biliari
residui, la colestasi intralobulare generalmente incompleta e la fibrosi.
Le sindromi da vanificazione dei dotti biliari comprendono patologie di
eziologia estremamente eterogenea (Tab. I) tra cui malattie congenite,
da anomalo sviluppo e acquisite
New insights on the molecular and cell biology of human cholangiopathies.
No full textMol Aspects Med. 2008 Feb-Apr;29(1-2):50-7. Epub 2007 Oct 24.
New insights on the molecular and cell biology of human cholangiopathies.
Alvaro D, Mancino MG.
SourceDivision of Gastroenterology, Department of Clinical Medicine, Rome, Italy.
Abstract
Cholangiopathies are diseases of high social impact representing the main indication for liver transplantation in the infanthood and the third in adulthood. Despite the heterogeneous etiology and pathogenesis, cholangiopathies share many different common morphological features and, chronically progress toward a ductupenic condition clinically evidenced by the classical features of a cholestatic syndrome. The primary target of damage in the course of cholangiopathies are cholangiocytes, the epithelia cells lining the biliary tree. A bulk of researches performed in the last decade, highlighted the extraordinary biological properties of cholangiocytes involved in a number of important processes such as bile formation, proliferation, injury repair, fibrosis, angiogenesis and regulation of blood flow. Recent advances on the molecular and cell biology of human cholangiopathies are opening new potential therapeutic perspectives for these diseases.
PMID: 18230407 [PubMed - indexed for MEDLINE
PTPN3 Mutations and HBV May Exert Synergistic Effects in the Origin of the Intrahepatic Cholangiocarcinoma
No full text[No abstract available
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