101,925 research outputs found
Topical anti-inflammatory activity of Solenostemma argel leaves
No full textThe topical anti-inflammatory activity of Solenostemma argel Hayne leaves was evaluated using the Croton oil ear test in mice. A bioassayguided
fractionation procedure led to a highly active chloroform extract: at 300 g/cm2, it induced 73% oedema reduction, while the reference
drug indomethacin (100g/cm2) induced 56% reduction. The extract contained a new pregnene glycoside (1, solenoside A) and the known
14,15-dihydroxy-4pregnene-3,20 dione (2), kaempferol-3-O-glucoside (3) and kaempferol-3-O-rutinoside (4). Their structures were
determined by ID and 2D NMR experiments as well as HRMS. Compounds 2 and 4 showed anti-inflammatory activity comparable to that of
indomethacin
Screening of the topical anti-inflammatory activity of some Central-American plants.
No full textHexane, chloroform and methanol extracts of seven herbal drugs used in the folk medicine of Central America against skin disorders (Aristolochia trilobata leaves and bark, Bursera simaruba bark, Hamelia patens leaves, Piper amalago leaves, and Syngonium podophyllum leaves and bark) were evaluated for their topical anti-inflammatory activity against the Croton oil-induced ear oedema in mice. Most of the extracts induced a dose-dependent oedema reduction. The chloroform extract of almost all the drugs exhibited interesting activities with ID(50) values ranging between 108 and 498 micro g/cm(2), comparable to that of indomethacin (93 micro g/cm(2)). Therefore, the tested plants are promising sources of principles with high anti-inflammatory activity
I residui di distillazione di Rosmarinus officinalis quali fonti di principi antinfiammatori.
No full text
Topical anti-inflammatory activity of Bauhinia tarapotensis leaves.
No full textThe topical anti-inflammatory properties of Bauhinia tarapotensis Benth. (Leguminosae) leaves have been studied by the inhibition of the croton oil-induced ear edema in mice. A bioassay-guided fractionation showed an interesting anti-inflammatory activity of the chloroform extract, that justifies the activity of the whole herbal drug. The main anti-inflammatory principles of B. tarapotensis leaves are triterpenic acids of ursane and oleanane series. The antiphlogistic activity of mixtures constituted of two ursane and oleanane isomers with different hydroxylation pattern, in the ratio 2:1, is comparable to that of indomethacin (ID50 ranging from 95 to 147 microg/cm2 and 93 microg/cm2, respectively)
Glaucopine A and B, New Cyathane Diterpenes from the fruiting bodies of Sarcodon glaucopus.
No full textGlaucopine A (1) and B (2), two new cyathane diterpenes, have been isolated from the mushroom Sarcodon glaucopus: their structures have been determined on the basis of spectral data. Their topical anti-inflammatory activity was evaluated using the Croton oil ear test in mice: compounds 1 and 2 (1 micromol/cm2) provoked edema reduction (62 % and 55 %, respectively) similar to that induced by the reference non-steroidal anti-inflammatory drug, indomethacin (0.3 micromol/cm2, 61 % edema reduction)
Innotrac Aio! a point-of-care or a routine analyzer? Analytical performance and plasma/whole blood comparison
No full textBackground and methods: The aim of the present study was to evaluate the analytical performance of the Innotrac Aio! analyzer in measuring the cardiac markers troponin I (Tnl), myoglobin (Myo) and creatine kinase-MB (CK-MB), both in lithium heparin plasma and in whole blood.
Results: TnI analytical sensitivity was 0.012 mu g/L and the concentration corresponding to CV=10% was 0.036 mu g/L. In healthy subjects, the 99th percentile TnI values were 0.023 and 0.016 mu g/L in whole blood and in plasma, respectively. One hundred samples were tested both in whole blood and in plasma: Tnl-whole-bloods=1.16-plasmaq+0.011, bias=0.18 (95% CI from -0.22 to +0.59); Myo-whole-blood=1.04-plasma -1.93, bias=+1.08 (95% CI from -6.17 to +8.32); CK-MB-whole-blood=1.11-plasma -0.09, bias=+0.96 (95% CI from -0.53 to +2.45). The method comparison with the RxL Dimension analyzer for TnI and Myo gave the following results: TnI AioI =0.30 TnI RxL + 0.00; bias=-5.80 (95% CI from -7.81 to -3.78), Myo Aio! =1.33 Myo RxL + 0.42, bias=+53.09 (95% CI from +38.44 to +67.74).
Conclusions: The analytical performance of the Innotrac Aio! analyzer was satisfactory for all three cardiac markers evaluated and, in particular, the TnI method provided sensitive and accurate results. The most important finding in this study is the possibility to perform the tests as either routine or point-of-care analysis, thus overcoming the variability of results obtained employing different methods
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