519 research outputs found
In the shadow of the church: the building of mosques in early medieval Syria
No full textIn his book In the Shadow of the Church: The Building of Mosques in Early Medieval Syria Mattia Guidetti examines the establishment of Muslim religious architecture within the Christian context in which it first appeared in the Syrian region, contributing to the debate on the transformation of late antique society to a Muslim one. He scrutinizes the slow process of conversion to Islam of the most important town centers by looking at religious places of both communities between the seventh and the eleventh century. The author assesses the relevancy of churches by analyzing the location of mosques and by researching phenomena of transfer of marble material from churches to mosques
Modello organizzativo dell'Istituto Tumori della Romagna (I.R.S.T.) e della Rete Oncologica Romagnola
No full textEconomic Burden of Denatured Alcohol-Induced Burns: A 20-Year Retrospective Study
No full textBurn care has rapidly improved over the past decades, but health innovations are expensive. We present the first study focusing on the economic burden of exclusive denatured alcohol-induced burns. The goal of this study was to determine costs for the public health system due to inpatients’ burn care because of these specific burns. Moreover, we aimed to observe the incidence of methylated spirit-related burns in the past 20 years. We performed an observational retrospective study in our burn unit including all patients with a denatured alcohol-related burn injury from 1 January 2001 to 31 December 2020. A total of 503 patients with a mean burn size of 24% were hospitalized; the mean annual total costs per patient was €43,879, varying from €31,518 to €63,274.00€; the total costs for denatured alcohol-related burns during the period 2001–2020 was €21,145,076. We noted an increasing incidence of denatured alcohol-related burns and related costs over the years, especially in the last decade. Our results highlight that burns by methylated spirits are still a real and expanding problem. Therefore, authorities should focus on sales rules, characteristics of the containers, and education of people who misuse denatured alcohol, based on historical habits of use. To reduce the socioeconomic costs of burns, future intervention strategies and studies from the dermatology community and burn specialists should focus on prevention programs and prompt wound healing to shorten the length of hospital stay, enable quick return to work, and improve the outcomes of patients with burns
Impressive long-term response with chemo-endocrine therapy in a premenopausal patient with metastatic breast cancer
No full textRationale: Patients with, or who develop, metastatic breast cancer have a 5-year relative survival of about 25%. Endocrine therapy clearly improves outcomes in patients with estrogen receptor-positive breast cancer. In the metastatic setting, the primary goal of treatment is to maintain long-term disease control with good quality of life. Rarely, exceptional responders achieve durable disease control, and potential cures cannot be ruled out.Patient Concerns: We report the case of a 39-year-old woman with primary breast cancer and associated synchronous bone metastases, who experienced a disease response of 12 years with hormonal therapy as maintenance after first line chemotherapy, with a good toxicity profile.Diagnosis: The patient was diagnosed with estrogen receptor + human epidermal growth factor receptor 2 (HER2)- metastatic breast cancer with synchronous bone metastases.Interventions: This patient was treated with chemotherapy for 6 cycles as a first-line therapy following by endocrine treatment given as a maintenance therapy.Outcomes: Our patient experienced a progression-free survival >12 years with an exceptionally good quality of life.Lessons: Our anecdotal experience highlights the existence of exceptional responders among patients with hormone receptor-positive metastatic breast cancer, who achieve clinical remission and durable disease control with endocrine therapy. Being able to identify these patients could help in the selection of the best treatment option among the many available
RESVERATROL-INDUCED AUTOPHAGY CONTRIBUTES TO THE INHIBITION OF EPSTEIN BARR VIRUS REPLICATION IN BURKITT’S LYMPHOMA CELLS
No full textRESVERATROL-INDUCED AUTOPHAGY CONTRIBUTES TO THE INHIBITION OF EPSTEIN BARR VIRUS REPLICATION IN BURKITT’S LYMPHOMA CELLS
De Leo Alessandra (a), Colavita Francesca (a), Arena Giuseppe (b), Mattia Elena (a)
(a) Dip. di Scienze di Sanità Pubblica e Malattie Infettive “Sanarelli”, Univ. di Roma “Sapienza”
(b) Casa Sollievo della Sofferenza Hospital, CSS-Mendel Institute, Roma
Presenting author: De Leo Alessandra, [email protected]
We have previously examined the antiviral activity of resveratrol on the replication of Epstein Barr Virus (EBV), the etiologic agent of infectious mononucleosis and associated with several types of malignancies of epithelial and lymphoid origin.
In a cellular context that allows in vitro EBV activation and lytic cycle progression through mechanisms closely resembling those that in vivo initiate and enable productive infection, we found that RV inhibited EBV lytic genes expression and the production of viral particles in a dose-dependent manner
Exploring Continuity of Care: The Patient Voice
No full textBackground: Oncology is one of the priorities of public health given its high incidence and prevalence. In 2010 there were 8 million deaths caused by cancer. In Italy neoplastic disease is the second highest cause of death. Considering these data, we need to guarantee appropriate, quality healthcare responses. In order to monitor the quality of cancer care pathways, we intend to explore continuity of care from patients’ perspective, identifying the dimensions that define continuity. Methods: Semi-structured interviews with 30 cancer patients (4 colorectal and 26 breast cancer) who received treatment at different service points of the Area Vasta Network (AVR), Italy. To identify the macro-categories of continuity, all interviews were transcribed and analysed using framework analysis, assisted by a computer software package for analysis of qualitative data (N-VIVO 10). Simultaneously, a literature review was carried out using the Pubmed database to examine the continuity of care measures validated. Results: From the narratives of 30 patients, different continuity of care’s dimensions emerged, for example the presence of a professional who knows the patient’s illness history and takes him/her from initial diagnosis to followup care, guaranteeing him/her accurate information; a multi-professional team. The same aspects result central and transversal to 5 questionnaires identified in literature. Conclusions: The analysis allows us to identify 3 central and transversal dimensions of continuity of care: informational, organizational and relational; confirming the continuity of care model produced by Haggerty et al. It follows that in order to cater to the needs of cancer patients; we need to focus simultaneously on these three dimensions along the cancer care pathway. In line with these results, we are developing the first Italian patients experience continuity of care tool
COVID-19 hospitalizations and cardio-cerebrovascular complications at three months in people with diabetes
No full textValidation of the OPportunity for Treatment In ONcology (OPTION) questionnaire measuring continuity of care
No full textIncreasing efforts are ongoing to deliver effective cancer care through integrated networks of services. Measuring patients' experience of care is essential to identify problematic areas that require organisational adjustments. The aim of the present study was to examine the validity of OPTION questionnaire, designed to measure patient's perceived continuity of care across different phases of their care pathway. The study was carried at the Institute for Cancer Treatment and Research, Meldola and the oncology departments of the Local Health Authority of Romagna, Italy. Principal component analysis (PCA) was performed to identify factors underlying patients' perception of continuity of care. Factor scores were compared between patients with or without a care coordinator using Mann-Whitney test. The study sample consisted of 214 patients with breast or colorectal cancer, with a mean age of 62.3 years. Most patients identified the oncologist as their care coordinator. Five factors were extracted using PCA: (1) "trustful relationship with health care staff," (2) "information on care pathway," (3) "information on changes related to the illness," (4) "feelings of abandonment" and (5) "collaboration among health care professionals." The scores of factors 2 and 3 were significantly higher among those with a care coordinator. The OPTION questionnaire is a reliable instrument that can help clinicians and administrative stakeholder target efforts and resources in the pursuit of quality of care
Does Independence Affect Regulatory Performance? The case of national competition authorities in the European Union
No full textDespite having always been assumed to be true, a relationship between the independence of regulatory agencies and their performance has never been formally tested. This paper aims at verifying whether formal regulatory independence affects the performance of national competition authorities in the EU member states. The author presents and discusses a statistical analysis which shows that greater formal independence leads competition authorities to investigate more cases and to issue more decisions
L’esperienza di cura di pazienti con neoplasia al colon retto e mammella in follow-up. L’indagine esplorativa nella Rete Oncologica di Area Vasta Romagna
No full textRiassunto. Premessa. Recenti studi evidenziano l’importanza di raccogliere le valutazioni dei pazienti sulla propria esperienza di cura e il dibattito sui differenti approcci per farlo. Nel sistema dei servizi oncologici, questo diventa particolarmente complesso, poiché richiede la considerazione di molteplici aspetti. Obiettivo e metodi. Lo studio è parte di un progetto di ricerca che ha l’obiettivo finale di valutare la continuità di cura nei servizi oncologici dalla prospettiva del paziente. In particolare, questo studio ha indagato l’esperienza di persone con neoplasia alla mammella e/o al colon retto nei servizi della Rete Oncologica di Area Vasta Romagna e si è sviluppato attraverso le seguenti fasi: interviste preliminari a 30 pazienti; analisi della letteratura sugli strumenti di valutazione; indagine di scopo attraverso la somministrazione di un questionario a 310 pazienti. Risultati. Dai risultati emergono alcuni aspetti dell’organizzazione che incidono nelle esperienze indagate, e che rappresentano ambiti di miglioramento nella rete dei servizi oncologici, tra cui: qualità comunicativa e informativa; qualità relazionale; individuazione precisa di un coordinatore del percorso; riconoscimento del ruolo del medico di medicina generale nella costruzione del percorso di cura; collaborazione e continuità informativa tra i professionisti ospedalieri
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