1,354,280 research outputs found
Professional judgment in accounting and auditing decisions
No full textThis call is broadly defined to include research that addresses topics across all domains of accounting and auditing, covering a wide range of issues and processes related to the use of judgments, with a preference to the application of materiality
GRINS - Growing Resilient, Inclusive and Sustainable
No full textmeasurement of social cohesion in Italian firms and performanc
HIV-1 Integrase and ALLINI Structure.
No full textA. Domain Map of HIV-1 Integrase. B. The preclinical lead ALLINI BI-224436. Chemical features common to the ALLINI class are highlighted, including a carboxylic acid moiety (salmon), a tert-butoxy moiety (green), and a large hydrophobic appendage at the R4 position (blue). C. Structure of HIV-1 IN CCD in complex with LEDGF/p75 Integrase Binding Domain (IBD, purple, PDB 2B4J). Shown below is the structure of HIV-1 IN CCD (blue) in complex with the ALLINI GSK1264 (PDB 5HOT). D. The IN-ALLINI structure reveals an open linear polymer configuration within the crystal lattice that underlies drug-induced aggregation. Outlined in black is the minimal ternary complex describing the ALLINI-induced protein-protein interaction between CCD and CTD. E. Cartoon Schematic of the CCD•CTD domain interactions stabilized by ALLINIs and a branched polymer model for drug-induced aggregation of HIV-1 IN.</p
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