1,720,979 research outputs found
A process for the preparation of Tolterodine and intermediates thereof
No full textA process for the preparation of 6-methyl-4-(R)-phenyl-chroman-2-one and 6-methyl-4-(S)-phenyl-chroman-2-one, intermediates for the synthesis of tolterodine and its (S) enantiomer, by reaction of 6-methyl-coumarin with phenylboronic acids, esters and derivatives thereof, in the presence of chiral catalysts
A process for the preparation of imiquimod and intermediates thereof
No full textNovel intermediates useful for the preparation of Imiquimod and a process for the preparation of Imiquimod with the intermediates
A process for the preparation of nitrile compounds used as intermediates in the synthesis of cysteinyl leukotrienes antagonists
No full textA process for the preparation of a compound of formula (I) or a salt thereof wherein R is an amino, nitro or -NHCOR 1 group, wherein R 1 is C 1 -C 6 alkyl or phenyl optionally substituted by a -O-(CH 2 ) n -phenyl group, wherein n is an integer of 1 to 6; comprising reacting a compound of formula (II) or a salt thereof, both as the individual isomer and as an isomeric mixture, wherein R is as defined above; with a dehydrating agent, if necessary in the presence of an organic solvent, and optionally in the presence of a basic agent; and, if desired, converting a compound of formula (I) to another compound of formula (I) or a salt thereof
Method for preparing valsartan and intermediate thereof
No full textA novel process for the preparation of valsartan and novel intermediates useful in the preparation thereof
Method for the preparation of Rufinamide
No full textThe present invention relates to a novel process for the preparation of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxyamide, namely Rufinamide. Rufinamide is a known compound with anticonvulsive action, specifically used in combination with other antiepileptic medicaments for the treatment of Lennox-Gastaut syndrome, a rare form of epileps
A process for the preparation of phenyltetrazole compounds
No full textA process for the preparation of olmesartan medoxomil, and derivatives thereof, by use of novel phenyltetrazole intermediate
Dioxolanone intermediate useful in the synthesis of Homoarringtonine
No full textThe invention discloses 2-((2R,4 R)-4-( 4-(benzyloxy)-4-methylpent-2-yn-1-yl)-2-(tert-butyl)-5-oxo-1 ,3-dioxolan-
4-yl)acetic acid of formula (XIX), a process for its preparation and processes for its conversion into enantiomerically pure (R)-2-(2-methoxy-2-oxoethyl)-6,6-dimethyltetrahydro-2H-pyran-2-carboxylic acid of formula (I), a molecule useful for the synthesis of Homoharringtonine
Piers–Rubinsztajn reaction to unlock an 8-step synthesis of 7-hydroxy cannabidiol
No full textA scalable synthesis of 7-hydroxy cannabidiol (7-OH CBD), a primary metabolite of (−)-cannabidiol (CBD), is
highly desirable, from an industrial point of view, to enable future clinical trials. A Piers–Rubinsztajn reaction
was key to enable a mild deprotection and a concise synthesis of 7-OH CBD from commercially available
CBD, in 31% overall yield.A scalable synthesis of 7-hydroxy cannabidiol (7-OH CBD), a primary metabolite of (-)-cannabidiol (CBD), is highly desirable, from an industrial point of view, to enable future clinical trials. A Piers-Rubinsztajn reaction was key to enable a mild deprotection and a concise synthesis of 7-OH CBD from commercially available CBD, in 31% overall yield.A Piers-Rubinsztajn reaction was key to enable a mild deprotection and a concise synthesis of 7-hydroxy cannabidiol from commercially available cannabidiol, in 31% overall yield
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