1,721,219 research outputs found
Bioinorganic Medicinal Chemistry
No full textIl libro contiene 13 capitoli, ognuno scritto da Autori noti a livello internazionale nel settore
Synthesis and Reactivity of Ru-, Os-, Rh-, and Ir-halide-sulfoxide Complexes.
No full textThis article, based on the author's first hand experience, makes a thorough and detailed account of the chemistry of widely used precursors in inorganic synthesis, i.e. ruthenium(III/II), osmium(II), rhodium(III/I), and iridium(III/I)-halide-sulfoxide complexe
Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective
No full textAs anticipated in the title, this contribution is basically divided into two, strictly connected, parts. The first is a personal overview of the ruthenium drug candidate NAMI-A, almost 30 years after its synthesis and the discovery of its unprecedented antimetastatic properties in animal models at nontoxic dosages. The sections relating to the chemical and biological behavior of the complex, and the hypotheses on its mechanism(s) of action, are kept to a minimum, whereas more space is devoted to discussion of the results of the clinical investigations. The second part deals in detail with a number of undemonstrated misconceptions (or myths) that, over the years, have thrived around NAMI-A and other ruthenium drug candidates, thus negatively affecting the whole field of Ru anticancer drugs
The catalytic reductive carbonylation of nitroaromatic com¬pounds to urethanes promoted by supported Pd activated with 1,10- phenanthroline derivatives.
No full text
Sistemi periodici: una proposta didattica interdisciplinare tra chimica e letteratura
Full text linkThis paper presents an example of interdisciplinary teaching between chemistry and literature. Our starting point was the analysis of Mendeleev’s periodic table and the collection of short stories “Il sistema periodico”, by Primo Levi, a chemist himself before becoming a writer. The main aim of the paper is to propose a dialogue between two different views of the world, trying to highlight the questions that both disciplines arise. i.e. in how many ways can we read and represent the world around us? How do we respond to our need for order? Faced with questions like these, chemistry and literature do not appear far from each other. Trying to work in this interdisciplinary perspective, the teaching proposal is organised in four steps: a thematic approach to Levi’s text; a presentation of the founding principles of Mendeleev’s table; a a digital processing in line with the methods of digital humanities; some final observations that can be shared with students who must be able to consider and tackle them
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