1,604 research outputs found
Lettera di Alessandra
No full textUn ritratto critico dell'opera di Alessandra Carnaroli, autrice fra le più apprezzate delle ultime generazioni della poesia di ricerca. La sezione a lei dedicata, nel numero della rivista, contiene inoltre saggi di Cecilia Bello Minciacchi, Andrea Cortellessa, e Ivan Schiavone; e vari inediti dell'autrice. Il saggio è pubblicato con lo pseudonimo di Tommaso Ottonieri.A critical portrait of the work of Alessandra Carnaroli, author of the most appreciated in the latest generations of italian research poetry. Published under the pseudonym Tommaso Ottonieri
Selected letters of Alessandra Strozzi
No full textThe letters of Alessandra Strozzi provide a vivid and spirited portrayal of life in fifteenth-century Florence. Among the richest autobiographical materials to survive from the Italian Renaissance, the letters reveal a woman who fought stubbornly to preserve her family's property and position in adverse circumstances, and who was an acute observer of Medicean society. Her letters speak of political and social status, of the concept of honor, and of the harshness of life, including the plague and the loss of children. They are also a guide to Alessandra's inner life over a period of twenty-three years, revealing the pain and sorrow, and, more rarely, the joy and triumph, with which she responded to the events unfolding around her.This edition includes translations, in full or in part, of 35 of the 73 extant letters. The selections carry forward the story of Alessandra's life and illustrate the range of attitudes, concerns, and activities which were characteristic of their author
Challenging the author: Gavin Douglas's Eneados
No full textGavin Douglas’s Eneados, a translation into the “Scottis” tongue of Virgil’s Aeneid, completed in 1513 and first published in London in 1553, presents, as well as the translation of the additional thirteenth book by Maphaeus Vegius, original prologues and marginal notes to the text, rubrics and articulate conclusive material. The present paper analyses this complex paratext as evidence of Douglas’s almost philological attention to the original and his preoccupation with a faithful reproduction; it is also suggested that the models for his organization of the commentary might be both medieval (i.e., manuscripts such as Petrarch’s Virgilius Ambrosianus) and early modern, as in the case of editions of classical works: the most apt example being Jodocus Badius Ascensius’ edition of the Aeneid, printed in 1501. The Eneados thus stands on the threshold between manuscript and print, and might have indicated new possibilities of use of the printing medium in Scotland, and of the value of the translation of a classical text, had history not intervened with the Scottish defeat at Flodden Fields in 1513, which put a temporary stop both to the circulation of the Eneados and to the development of Scottish printing
Experimental Drugs for Panic Disorder: An Updated Systematic Review
No full textDaniela Caldirola,1,2 Alessandra Alciati,1– 3 Francesco Cuniberti,1,2 Giampaolo Perna1,2 1Department of Biomedical Sciences, Humanitas University, Milan, 20090, Italy; 2Department of Clinical Neurosciences, Villa San Benedetto Menni Hospital, Hermanas Hospitalarias, Como, 22032, Italy; 3Humanitas Clinical and Research Center, IRCCS, Milan, Rozzano, 20089, ItalyCorrespondence: Daniela CaldirolaDepartment of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, Milan, 20090, ItalyEmail [email protected]: Several effective pharmacological therapies for panic disorder (PD) are available, but they have some drawbacks, and unsatisfactory outcomes can occur. Expanding the variety of anti-panic medications may allow for improving PD treatment. The authors performed an updated systematic review of preclinical and clinical (Phase I–III) pharmacological studies to look for advances made in the last six years concerning novel-mechanism-based anti-panic compounds or using medications approved for nonpsychiatric medical conditions to treat PD. The study included seven published articles presenting a series of preclinical studies, two Phase I clinical studies with orexin receptor (OXR) antagonists, and two clinical studies investigating the effects of D-cycloserine (DCS) and xenon gas in individuals with PD. The latest preclinical findings confirmed and expanded previous promising indications of OXR1 antagonists as novel-mechanism-based anti-panic compounds. Translating preclinical research into clinical applications remains in the early stages. However, limited clinical findings suggested the selective OXR1 antagonist JNJ-61393115 may exert anti-panic effects in humans. Overall, OXR1 antagonists displayed a favorable profile of short-term safety and tolerability. Very preliminary suggestions of possible anti-panic effects of xenon gas emerged but need confirmation with more rigorous methodology. DCS did not seem promising as an enhancer of cognitive-behavioral therapy in PD. Future studies, including objective panic-related physiological parameters, such as respiratory measures, and expanding the use of panic vulnerability biomarkers, such as hypersensitivity to CO2 panic provocation, may allow for more reliable conclusions about the anti-panic properties of new compounds.Keywords: novel drug, experimental therapy, orexin, D-cycloserine, xenon ga
Nicetas Nicaenus, De azymis
No full textThe RAP online repertorium offers the first comprehensive catalogue of polemical literature related to the schism between the Roman Catholic and Orthodox Churches from the 9th to the 16th century and can be described as an ideal continuation of the *Clavis Patrum*.
Each entry identifies the work (often unpublished or newly discovered in manuscript catalogs), lists its various titles (since medieval texts often lack stable titles), provides incipit and explicit (with possible variations), and examines the manuscript tradition and foliation (by reviewing catalogs or manuscripts, verifying dates, folios, etc.). It also includes relevant bibliography (critical editions and studies), identifies the author (using prosopographical studies, dictionaries, repertories, sigillography, etc.), and provides essential biographical details. Each work is classified by literary genre (e.g., treatise, dialogue), the corresponding Byzantine term, and the main polemical themes (e.g., Filioque, Azymes, Purgatory), and is assigned a unique RAP identification number.
The Repertorium Auctorum Polemicorum is identified by the International Standard Serial Number (ISSN) 3035-2096 [continuously updated publication
Polemica scripta anonyma, Dialogus inter Graecum et Cardinales quosdam de processione Spiritus Sancti
No full textThe RAP online repertorium offers the first comprehensive catalogue of polemical literature related to the schism between the Roman Catholic and Orthodox Churches from the 9th to the 16th century and can be described as an ideal continuation of the *Clavis Patrum*.
Each entry identifies the work (often unpublished or newly discovered in manuscript catalogs), lists its various titles (since medieval texts often lack stable titles), provides incipit and explicit (with possible variations), and examines the manuscript tradition and foliation (by reviewing catalogs or manuscripts, verifying dates, folios, etc.). It also includes relevant bibliography (critical editions and studies), identifies the author (using prosopographical studies, dictionaries, repertories, sigillography, etc.), and provides essential biographical details. Each work is classified by literary genre (e.g., treatise, dialogue), the corresponding Byzantine term, and the main polemical themes (e.g., Filioque, Azymes, Purgatory), and is assigned a unique RAP identification number.
The Repertorium Auctorum Polemicorum is identified by the International Standard Serial Number (ISSN) 3035-2096 [continuously updated publication
Theophylactus Bulgariae archiepiscopus, Allocutio ad quemdam ex suis familiaribus de iis quorum Latini incusantur
No full textThe RAP online repertorium offers the first comprehensive catalogue of polemical literature related to the schism between the Roman Catholic and Orthodox Churches from the 9th to the 16th century and can be described as an ideal continuation of the *Clavis Patrum*.
Each entry identifies the work (often unpublished or newly discovered in manuscript catalogs), lists its various titles (since medieval texts often lack stable titles), provides incipit and explicit (with possible variations), and examines the manuscript tradition and foliation (by reviewing catalogs or manuscripts, verifying dates, folios, etc.). It also includes relevant bibliography (critical editions and studies), identifies the author (using prosopographical studies, dictionaries, repertories, sigillography, etc.), and provides essential biographical details. Each work is classified by literary genre (e.g., treatise, dialogue), the corresponding Byzantine term, and the main polemical themes (e.g., Filioque, Azymes, Purgatory), and is assigned a unique RAP identification number.
The Repertorium Auctorum Polemicorum is identified by the International Standard Serial Number (ISSN) 3035-2096 [continuously updated publication
Effect of biological DMARDs and JAK inhibitors in pain of chronic inflammatory arthritis
No full textIntroduction: The advent of biological disease-modifying anti-rheumatic drugs (bDMARDs) and, more recently, of Janus kinase inhibitors (JAKi) has had a major impact on the long-term outcomes of chronic inflammatory arthritis (IA). However, the persistence of pain, even in patients with a complete pharmacological control of peripheral inflammation, represents an important clinical challenge in the treatment of IA.
Areas covered: In this review, we provide an overview of possible mechanisms underlying pain in IA and its assessment, as well as the effects of bDMARDs and JAKi on pain management.
Expert opinion: The overall data showed a good effect of bDMARDs and JAKi on pain, more pronounced for JAKi. However, it is challenging to distinguish the effect on the different types of pain (nociceptive, neuropathic, and nociplastic)
Polemica scripta anonyma, Contra unionem ecclesiarum
No full textThe RAP online repertorium offers the first comprehensive catalogue of polemical literature related to the schism between the Roman Catholic and Orthodox Churches from the 9th to the 16th century and can be described as an ideal continuation of the *Clavis Patrum*.
Each entry identifies the work (often unpublished or newly discovered in manuscript catalogs), lists its various titles (since medieval texts often lack stable titles), provides incipit and explicit (with possible variations), and examines the manuscript tradition and foliation (by reviewing catalogs or manuscripts, verifying dates, folios, etc.). It also includes relevant bibliography (critical editions and studies), identifies the author (using prosopographical studies, dictionaries, repertories, sigillography, etc.), and provides essential biographical details. Each work is classified by literary genre (e.g., treatise, dialogue), the corresponding Byzantine term, and the main polemical themes (e.g., Filioque, Azymes, Purgatory), and is assigned a unique RAP identification number.
The Repertorium Auctorum Polemicorum is identified by the International Standard Serial Number (ISSN) 3035-2096 [continuously updated publication
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