227 research outputs found
Effects of Withaferin A on Mouse Models of Alexander Disease
No full textAlexander disease is a rare neurodegenerative disorder which is caused by the accumulation of glial fibrillary acidic protein (GF AP) resulting in aggregates termed Rosenthal Fibers (RFs) in the central nervous system. TAR DNA-binding protein 43(TDP-43) is a DNA/RNA binding protein that is involved in the pathology of disorders
such as amyotrophic lateral sclerosis (ALS) as well as Alexander disease. Withaferin A(WA) is a plant derivative and known inhibitor ofNF-Kl3, and activated NF-KB targets the GF AP promoter. We proposed that treatment of the mice with WA should downregulate the GFAP promoter. We treated 10 week old Alexander disease mutation GFAP
knock-in mice with WA twice a week for 4 weeks. After treatment we analyzed the amount of GF AP protein concentration with an ELISA. Results showed an initial significant decrease in GF AP, but after repeating the experiment and analyzing specific brain regions, treatment was determined to be slightly toxic
Archetypal and New Families With Alexander Disease and Novel Mutations in <emph type="ital">GFAP</emph>
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Frances Burney and her readers : the negotiated image
No full textIn Frances Burney and Her Readers, Anna Paluchowska-Messing traces the rugged trajectory marked by the literary career of Frances Burney, the English eighteenth-century novelist, diarist and playwright. The study highlights the techniques Burney employed in her texts for projecting a favourable self-image, and sets them against the changing conventions in culture consumption and appreciation. More broadly, the study addresses the concept of women’s literary celebrity, which in late eighteenth-century England remained at odds with contemporary ideals of feminine respectability and prescribed domesticicity. In Paluchowska-Messing’s representation, Burney’s story showcases the dilemmas an eighteenth-century author must face at different stages of her career from debutante to that of an acclaimed literary figure, and possible solutions she might choose in order to court celebrity without losing respectability
Treatise on Invertebrate Paleontology
No full textThis volume is edited by Paul Selden, authors are Hans Hess and Charles G. Messing, coordinating author is William I. Ausich. This is the first volume to be published in an extensive revision of the Class Crinoidea. The present volume deals with the Subclass Articulata that contains all post-Paleozoic and living crinoids. The descriptions are preceded by an introduction, a chapter on the morphology of articulate crinoids, a glossary of important terms, and an overview of classification. The reference list is comprehensive for this volume.https://nsuworks.nova.edu/occ_facbooks/1009/thumbnail.jp
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