2,160 research outputs found
High Glucose Induces Adipogenic Differentiation of Muscle-Derived Stem Cells
No full textRegeneration of mesenchymal tissues depends on a resident stem cell population, that in
most cases remains elusive in terms of cellular identity and differentiation signals. We here
show that primary cell cultures derived from adipose tissue or skeletal muscle differentiate
into adipocytes when cultured in high glucose. High glucose induces ROS production and
PKCβ activation. These two events appear crucial steps in this differentiation process that can
be directly induced by oxidizing agents and inhibited by PKCβ siRNA silencing. The
differentiated adipocytes, when implanted in vivo, form viable and vascularized adipose
tissue. Overall, the data highlight a previously uncharacterized differentiation route
triggered by high glucose that drives not only resident stem cells of the adipose tissue but
also uncommitted precursors present in muscle cells to form adipose depots. This process
may represent a feed‐forward cycle between the regional increase in adiposity and insulin
resistance that plays a key role in the pathogenesis of diabetes mellitus
Filologia editoriale, Roberto Calasso in dialogo con Paola Italia e Francisco Rico
No full textPaola Italia e Francisco Rico intervengono sul libro di Roberto Calasso, presidente e fondatore di Adelphi Edizioni, L'impronta dell'editore, e discutono di problemi di filologia delle forme editoriali, dal punto di vista dell'autore, del lettore e dell'editore.Paola Italia and Francisco Ricos interview Roberto Calasso, Publisher, Writer, and Founder of Adelphi Edizioni, about his book: L'impronta dell'editore, talking about philology, publishing and editing, from the author, the reader and the publisher's point of view
Paola Gianturco: Women Who Light the Dark
No full textPaola Gianturco is a photographer, author, and advocate for women\u27s rights world-wide. For the past thirteen years, she has worked as a photojournalist, documenting women’s lives in forty countries. She has published four acclaimed photo books which bring together inspiring stories with gorgeous photographs to motivate her readers to engage with, learn from and support women around the world. All of Gianturco’s books are philanthropic projects, for which she donates her royalties to carefully selected nonprofit organizations that relate to each book\u27s content. Paola\u27s most recent book, Women Who Light the Dark, tells the story of local women around the world who are helping one another tackle the problems that darken their lives—including violence, poverty, illiteracy and disease. Gianturco is giving 100% of her author royalties for this book to The Global Fund for Women.https://thekeep.eiu.edu/humanitiescenter_meaningfulwork1011/1002/thumbnail.jp
Mechanical testing of pericardium for manufacturing prosthetic heart valves
No full textMammalian pericardia are currently used for the production of percutaneous prosthetic heart valves. The characteristics of biological tissues largely influence the durability of prosthetic devices used in the percutaneous approach and in traditional surgery, too. This paper reviews methodologies employed to assess and compare mechanical properties of pericardial patches from different mammalian species in order to identify the biomaterials adequate for manufacturing prosthetic heart valves
Biocompatibility Evaluation Criteria for Novel Xenograft Materials: Distribution and Quantification of Remnant Nucleic Acid and Alpha-Gal Epitope
No full text«Yo soy de Destierrolandia»: Fernando Arrabal y el límite
No full textFernando Arrabal is a Spanish author - actually, no, he isn't. He is a francophone writer, or, more accurately, a Spanish expatriate. Or, on the contrary, he is a traitor, an «afrancesado». In this paper Fernando Arrabal's case will be used as an example of the difficulties that an author has to face when he leaves his own country and moves to another different from a spatial, cultural, and linguistic point of view. Besides, I will analyze the unusual position of the critic in the reception and interpretation of a corpus that, while being obviously connected to its author, cannot refer to a precise national context
On assessing the accuracy of air pollution models exploiting a strategic sensors deployment
No full textThis paper presents a preliminary experiment done to identify potential problems and issues in setting up a testbed for air pollution measurement and modeling. Our final testbed, part of a joint research activity between the University of Bologna and the Macao Polytechnic Institute, will be composed of three lines of the air pollution sensors Canarin II and it will be used to produce spatio-temporal open data to test third-party air pollution models. Here, we present a preliminary experiment based on a single line of sensors, showing interesting insights into the actual open challenge of air pollution modeling techniques validation, taking into account the effects of air pollutant emissions sources, meteorology, atmospheric concentrations and urban vegetation
Native Bovine and Porcine Pericardia Respond to Load With Additive Recruitment of Collagen Fibers
No full textBovine and porcine pericardia are currently used for manufacturing prosthetic heart valves: their design has become an increasingly important area of investigation in parallel with progressively expanding indications for the transcutaneous approach to heart valves replacement. Before being cut and shaped, pericardial tissues are expected to be properly characterized. Actually, the mechanical assessment of these biomaterials lacks standardized protocols. In particular, the role of preconditioning for achieving a constant mechanical response of tissue samples is still controversial. In the present work, the mechanical response to uniaxial load of native bovine and porcine pericardia, with and without preconditioning was assessed; moreover, the mechanical behavior of pericardia was investigated and explained. It was demonstrated that: (i) pericardial tissue samples hold memory of the loading history but just within the extent of the deformation applied; (ii) the behavior of native bovine and porcine pericardia in response to load is explained by a mechanism based on the additive recruitment of collagen fibers; (iii) the current concept that plasticity is absent in pericardium has to be at least in part reconsidered
Decellularized Cryopreserved Allografts as Off-the-Shelf Allogeneic Alternative for Heart Valve Replacement: In Vitro Assessment Before Clinical Translation
No full textIntroduzione, a Mario Tobino, Il Clandestino
No full textL'introduzione presenta il libro più ambizioso di Mario Tobino, Il Clandestino, dedicato al racconto della sua esperienza con i gruppi clandestini della Resistenza Viareggina, libro con cui l'autore vinse il Premio Strega, nel 1962, imponendosi all'attenzione del grande pubblico dopo il successo dei libri manicomiali. Una nuova edizione in cui Paola Italia valorizza i materiali inediti dell'Archivio Tobino conservato presso l'Archivio Contemporaneo A. Bonsanti del Gabinetto GP Vieusseux di Firenze,Paola Italia presents an Introduction to the new edtion of Il Clandestino, the most ambitious of Mario Tobino's novels, dedicated to the story of his experience with the groups of the Tuscan Resistance when he was a psichiatric doctor ar Lucca. With this book the author won the Strega Prize, in 1962, attracting the attention of a wide public after the success of his psichiatric books. A new edition where Paola Italia enhances the unpublished material of Tobino Archive preserved in A. Bonsanti Contemporary Archive of G.P. Vieusseux Cabinet of Florence
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