1,721,012 research outputs found
La trascrizione delle durate nella polivocalità popolare a due parti in Italia
No full textLa trascrizione delle durate nella polivocalità popolare a due parti in Itali
Broad-Spectrum Activity of Small Molecules Acting against Influenza a Virus: Biological and Computational Studies
No full textInfluenza still represents a problematic disease, involving millions of people every year and causing hundreds of thousands of deaths. Only a few drugs are clinically available. The search for an effective weapon is still ongoing. In this scenario, we recently identified new drug-like compounds with antiviral activity toward two A/H1N1 Influenza virus strains, which were demonstrated to interfere with the processes mediated by hemagglutinin (HA). In the present work, the compound’s ability to act against the A/H3N2 viral strain has been evaluated in hemagglutination inhibition (HI) assays. Two of the five tested compounds were also active toward the A/H3N2 Influenza virus. To validate the scaffold activity, analogue compounds of two broad-spectrum molecules were selected and purchased for HI testing on both A/H1N1 and A/H3N2 Influenza viruses. Forty-three compounds were tested, and four proved to be active toward all three viral strains. A computational study has been carried out to depict the HA binding process of the most interesting compounds
Le ragioni della musica. Scritture di musicologia africanista
No full textIl testo è una raccolta di articoli di Simha Arom, selezionati arricchiti da note da parte dei curatori, Maurizio Agamennone e Serena Facci. Gli articoli coprono un arco temporale dei circa cinquant'anni della carriera del famoso etnomusicologo mettendo in luce i temi centrali della sua ricerca in Africa Centrale. Gli articoli sono prceduti da una lunga intervista realizzata all'autore dai due curatori. Un CD and a DVD completano il lavoro.The book (with a CD and a DVD) is a collection of articles written by Simha Arom during fifty years and selected by Maurizio Aganmenno and Serena Facci. These articles touch the main topics of the ethnomusicological research done by Arom in Central Africa
Presentazione
No full textPrefazione al libro "Le ragioni della musica. Scritture di musicologia africanista", una raccolta di saggi di Simha Arom curata da M. Agamennone e S. Facci.The Preface to "Le ragioni della musica. Scritture di musicologia africanista", a collection of articles of Simha Arom, edited by M. Agamennone and Serena Facci
Conversazione con un maestro
No full text"Conversazione con un maestro" è un capitolo della raccolta di saggi di Simha Arom raccolta a cura di Maurizio Agamennone e Serena Facci. In questa lunga intervista i due curatori sollecitano l'autore a discutere il contenuto dei saggi che coprono un arco temporale di circa cinquanta anni. I temi toccati riguardano le modalità della ricerca sul campo, il contributo dell'etnomusicologia alla musicoloogia generale, la poliritmia nella musica dell'Africa Centrale e altri argomenti centrali nell'operato del famoso musiclogo.A long interview to Simha Arom about his ethnomusicological researches in Central Africa. It is part of the book "Le ragioni della musica. Pagine di musicologia africanista", a collection of articles written by Arom, edited by M. Agamennone and S. Facci
Inflammatory pseudotumor of soft tissues. Report of a case with double localization in lower limb muscles
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N-hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: Mode of binding in a complex with MMP-8
No full textCampestre C, Agamennone M, Tortorella P, et al. N-hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: Mode of binding in a complex with MMP-8. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2006;16(1):20-24.The first crystallographic structure of an N-hydroxyurea inhibitor bound into the active site of a matrix metalloproteinase is reported. The ligand and three other analogues were prepared and studied as inhibitors of MMP-2, MMP-3, and MMP-8. The crystal structure of the complex with MMP-8 shows that the N-hydroxyurea, contrary to the analogous hydroxamate, binds the catalytic zinc ion in a monodentate rather than bidentate mode and with high out-of-plane distortion of the amide bonds. (c) 2005 Elsevier Ltd. All rights reserved
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