2,242 research outputs found
C. C. Mehta
No full textOn the life and works of Chandravadan Chimanlal Mehta, b. 1901, Gujarati author
Ab initio phase diagrams of binary alloys in the low solute concentration limit
No full textPhase diagrams are crucial to the design of new materials, to understand their phase stability and metastability under different thermodynamic conditions, such as composition, temperature, and pressure. Here, we use an ab initio approach to study the phase diagram of a binary alloy within the low concentration limit of a solute. Using the ab initio molecular dynamics calculations based on density functional theory, we estimate the solute partitioning ratios in solid–liquid phase equilibria. The chemical potential difference between the solvent and solute atoms in both solid and liquid phases is calculated using thermodynamic integration. As an illustration of the techniques, we have applied this method to reproduce the phase diagram of the Al–Mg alloy at zero pressure. We also compute the ab initio solid–liquid coexistence curve of pure Al by applying the phase-coexistence method with the free energy correction technique. The calculated results are in close agreement with the experiment, demonstrating the reliability of the models
Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells
No full textCopyright @ 2011 Mehta et al.; licensee BioMed Central Ltd. This article has been made available through the Brunel Open Access Publishing Fund.
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.BACKGROUND: Hutchinson-Gilford progeria syndrome (HGPS) is a premature ageing syndrome that affects children leading to premature death, usually from heart infarction or strokes, making this syndrome similar to normative ageing. HGPS is commonly caused by a mutation in the A-type lamin gene, LMNA (G608G). This leads to the expression of an aberrant truncated lamin A protein, progerin. Progerin cannot be processed as wild-type pre-lamin A and remains farnesylated, leading to its aberrant behavior during interphase and mitosis. Farnesyltransferase inhibitors prevent the accumulation of farnesylated progerin, producing a less toxic protein. RESULTS: We have found that in proliferating fibroblasts derived from HGPS patients the nuclear location of interphase chromosomes differs from control proliferating cells and mimics that of control quiescent fibroblasts, with smaller chromosomes toward the nuclear interior and larger chromosomes toward the nuclear periphery. For this study we have treated HGPS fibroblasts with farnesyltransferase inhibitors and analyzed the nuclear location of individual chromosome territories. We have found that after exposure to farnesyltransferase inhibitors mis-localized chromosome territories were restored to a nuclear position akin to chromosomes in proliferating control cells. Furthermore, not only has this treatment afforded chromosomes to be repositioned but has also restored the machinery that controls their rapid movement upon serum removal. This machinery contains nuclear myosin 1β, whose distribution is also restored after farnesyltransferase inhibitor treatment of HGPS cells. CONCLUSIONS: This study not only progresses the understanding of genome behavior in HGPS cells but demonstrates that interphase chromosome movement requires processed lamin A.This work was funded by an ORSAS award and the Brunel Progeria Research Fund
Mobilities in Religious Knowledge: Phiroz Mehta and the Logics of Transreligiosity in 1970s–80s South London
No full textThis paper examines transreligiosity in the context of the transmission of South Asian concepts of spirituality to the UK in the 20th century. Between the 1920s and 1990s, Indian teacher and author Phiroz Mehta (1902–1994) crossed borders in a colonial and postcolonial shuttling between India and the UK but also transgressed conceptual and practice borders of religion, teaching Indian religious concepts to post-Christian spiritual seekers in 1970s–80s South London. Mehta cultivated an elasticity between many religious and philosophical traditions, recognising the post-institutional fatigue of subjects who sought alternative forms of ‘belonging without believing’. Privileging the domestic space for teaching, as well as transitory ‘camp’ gatherings in the UK and Germany, Mehta often operated in the social margins, combining teachings from Hinduism, Buddhism, and Christianity with Zoroastrianism, Judaism (specifically Kabbalah), and Daoism. He offered his tutees the freedom to practice religion in whatever way they chose by drawing on a broad range of traditions concurrently to create a transreligiosity. This paper examines Panagiotopoulos and Roussou’s ‘transgressional webs of practising individualised forms of alternative spirituality’ in relation to Mehta’s followers in the 1970s-1980s and asks how transreligiosity relates to other theoretical analyses, such as religious exoticism, bricolage, religious appropriation, cultural re-articulation or assemblage. This paper focuses on qualitative interviews with original members of the Mehta community conducted between 2021 and 2022.</p
Design and development of a mechatronic training simulator for adult ECMO
No full textWidespread adoption of Extracorporeal Membrane Oxygenation (ECMO) in adults has been limited by unfamiliarity with the procedure, including cannulation and safe handling of the ECMO equipment. We present the design and development of a mechatronic training simulator for ECMO that can help medical professionals acquire the needed skills, gain familiarity, and reduce errors by practicing before performing the procedure on real patients. The trainer is designed as an ultrasound-compatible, wholesome simulator with realistic components such as synthetic blood vessels, cannulation pads, and a color-changing blood simulant to simulate oxygenation and deoxygenation. The simulator is integrated with a mathematical model of human physiology to simulate real-time patient vitals and training scenarios, and to control the trainer hardware. We present results related to successful cannulation under ultrasound scanning and a simple patient scenario of hypovolemia.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2021-05-01The student, Iti Mehta, accepted the attached license on 2019-04-24 at 10:58.The student, Iti Mehta, submitted this Thesis for approval on 2019-04-24 at 11:11.This Thesis was approved for publication on 2019-04-24 at 12:45.DSpace SAF Submission Ingestion Package generated from Vireo submission #13873 on 2019-08-22 at 15:08:02Made available in DSpace on 2019-08-23T20:36:09Z (GMT). No. of bitstreams: 2
MEHTA-THESIS-2019.pdf: 84393765 bytes, checksum: 74f0edf247057995595372eb8076e513 (MD5)
LICENSE.txt: 4206 bytes, checksum: 30fb64a86cfc352d6579ccb023b2a936 (MD5)
Previous issue date: 2019-04-24Embargo set by: Seth Robbins for item 112203
Lift date: 2021-08-23T20:36:18Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 112203 on 2021-08-24T09:15:24Z
Optimal Bioeconomic Management Strategies for Prevention and Control of Invasive Alien Species
No full textPaper removed by author. Please see the current version, available online January 8, 2007: Mehta, S.V. et al. Optimal detection and control strategies for invasive species management. Ecological Economics (2007), doi:10.1016/j.ecolecon.2006.10.024Environmental Economics and Policy,
Ab initio thermodynamics and phase diagram of solid magnesium: A comparison of the LDA and GGA
No full textThe finite temperature density functional theory and quasiharmonic lattice dynamics have been used to compute numerous thermodynamic properties of hexagonal close packed magnesium using both the local density approximation (LDA) and the generalized gradient approximation (GGA) for the exchange-correlation potential. Generally, it is found that there exist only minor differences between the LDA and GGA computed properties, with both giving good agreement with experiment. The hcp-bcc phase boundary has also been computed and is found to be in agreement with experimental observation. Again, only slight differences are found between the LDA and GGA. (c) 2006 American Institute of Physics
Design and implementation of a phase locked loop for high-speed serial links
No full textThe student, Rushabh Mehta, accepted the attached license on 2016-04-25 at 13:40.The student, Rushabh Mehta, submitted this Thesis for approval on 2016-04-25 at 13:46.This Thesis was approved for publication on 2016-04-27 at 14:52.DSpace SAF Submission Ingestion Package generated from Vireo submission #9475 on 2016-07-07 at 13:50:45Made available in DSpace on 2016-07-07T20:27:59Z (GMT). No. of bitstreams: 2
MEHTA-THESIS-2016.pdf: 13984347 bytes, checksum: 4ecb06c5c270bc1beffb061eeae85eef (MD5)
LICENSE.txt: 4210 bytes, checksum: e6aea67d4e02d64f06671bb40ada2274 (MD5)
Previous issue date: 2016-04-27Recent advances in the semiconductor industry and process technology scaling have increased the demand for fast, robust computing. The thirst for high-processing, low power ICs is ever increasing. This has pushed the demand for high data rates in wireless and wireline communication systems in the multi-Gbps range. With higher data rates, the I/O links need to scale proportionally. However, the I/O channel bandwidth has not scaled appropriately making it the biggest bottleneck in high-speed links. Parallel links have not been able to match this increasing system performance due to issues such as crosstalk, timing skew and packaging costs. Thus there is a need for high-speed serial links. For high-speed transmission of data, there arises a need for high-speed on chip clocking circuits making the use of Phase-Locked Loops (PLLs) imperative.
This thesis includes an overview of high-speed links along with the need for PLLs. An in-depth understanding of PLL theory, loop dynamics and behavioral and transistor level simulation follows. Performance metrics such as phase noise, random jitter and deterministic jitter are discussed. Finally, this thesis concludes with an insight into All Digital Phase-Locked Loops (ADPLLs).Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-05-01Embargo set by: Seth Robbins for item 93174
Lift date: 2018-07-07T20:28:14Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 93174
Lift date: 2018-07-07T20:35:34Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 93174 on 2018-07-08T09:15:20Z
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