185 research outputs found
Programming Long-Term Health: Effect of Parent Feeding Approaches on Long-Term Diet and Eating Patterns
No full textThe role of educative thought in the life and work of Antonio Gramsci
No full textMany philosophers have propounded a vision of an improved society, what distinguishes Antonio Gramsci is his continuous effort to make it happen by understanding the process in order to put into practice. Gramsci's conviction about the importance of educative development came from both theory and experience. While there has been considerable examination of Gramsci's work in relation to the Prison Notebooks, this study will seek to address a lacuna in Gramsci scholarship. Using Gramsci's philological method, I analyse Gramsci's pre-prison activity; his pre-prison articles and letters, which, together with his letters from prison, formed part of his educative mission. This educative process was necessary, in order to construct a new party which would develop a collective will, collaboratively, with the masses.In this study therefore, I explore the contexts and formative experiences of the first part of his life together with the intellectual sources from which Gramsci developed his later theories, making central hitherto underemphasised connections between them which informed his writing and ideas. I intend to illustrate that Gramsci's underlying purpose in his writing, and political activity, was not only practical, on how to create a new socialist ruling class, but also educative in forming the mindset and values of his comrades. So that in addition to outlining his vision of a new order, he implicitly guided or explicitly explained the processes by which the necessary changes in social relations and moral climate could be made in order to achieve it. Each person had to engage with the values of the new order so that each could contribute to the construction of a new robust state. It was essential to build a hegemony at the most profound level, one which was dependent on collective understandings and a collective will
The Ponies of the Giara highland
No full textSummaryThe Giara pony is a less known, equine breed of small stature, typical of the island of Sardinia. It draws its denomination from the highland of the Giara, where it lives in the wild.The ponies appeared in Sardinia approximately in the VII century B. C. Recent research, carried out on haemoglobin polymorphism, underlined some analogies with the Arabic horses of North-Africa.These ponies, have a dolyichomorphic-type constitution with long, naked and resistant legs. In the past they were used for agricultural work, however later, with the increase of mechanisation, they returned to the Giara highland where they became feral.The Giara ponies, in the light of recent scientific research, possess not only an inestimable genetic patrimony but they also represent a large source of interest for the equestrian sport, and, above all, for children's riding therapy.The author underlines, finally, that the principal material of this article has been outlined in a symposium held at the University of Sassari 18/11/1997, entitled: “Phenomenology of the environment: psycho-social and zoo-anthropological perspectives”.</jats:p
Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma
No full textCircular RNAs (circRNAs) represent a class of covalently closed RNAs, derived from non-canonical splicing events, which are expressed in all eukaryotes and often conserved among different species. We previously showed that the circRNA originating from the ZNF609 locus (circ-ZNF609) acts as a crucial regulator of human primary myoblast growth: indeed, the downregulation of the circRNA, and not of its linear counterpart, strongly reduced the proliferation rate of in vitro cultured myoblasts. To deepen our knowledge about circ-ZNF609 role in cell cycle regulation, we studied its expression and function in rhabdomyosarcoma (RMS), a pediatric skeletal muscle malignancy. We found that circ-ZNF609 is upregulated in biopsies from the two major RMS subtypes, embryonal (ERMS) and alveolar (ARMS). Moreover, we discovered that in an ERMS-derived cell line circ-ZNF609 knock-down induced a specific block at the G1-S transition, a strong decrease of p-Akt protein level and an alteration of the pRb/Rb ratio. Regarding p-Akt, we were able to show that circ-ZNF609 acts by counteracting p-Akt proteasome-dependent degradation, thus working as a new regulator of cell proliferation-related pathways. As opposed to ERMS-derived cells, the circRNA depletion had no cell cycle effects in ARMS-derived cells. Since in these cells the p53 gene resulted downregulated, with a concomitant upregulation of its cell cycle-related target genes, we suggest that this could account for the lack of circ-ZNF609 effect in ARMS. © 2019, The Author(s)
ICH3, a selective alpha7 nicotinic acetylcholine receptor agonist, modulates adipocyte inflammation associated with obesity
No full textPurpose: The alpha7 nicotinic acetylcholine receptor (α7nAChR), involved in the modulation of inflammation and insulin sensitivity, is downregulated in white adipose tissue (WAT) of obese patients. This study aims to test the ability of a selective synthetic α7nAChR agonist, the spirocyclic Δ2-isoxazoline derivative (R)-(−)-ICH3 (ICH3), to counteract acute inflammation and obesity-associated modifications in WAT. Methods: We employed the LPS-septic shock murine model, human primary adipocytes and diet-induced obese (DIO) mice. Inflammatory factor expression was assessed by ELISA and quantitative real-time PCR. Flow cytometry was employed to define WAT inflammatory infiltrate. Insulin signaling was monitored by quantification of AKT phosphorylation. Results: In the septic shock model, ICH3 revealed antipyretic action and reduced the surge of circulating cytokines. In vitro, ICH3 stimulation (10 μM) preserved viability of human adipocytes, decreased IL-6 mRNA (P < 0.05) and blunted LPS-induced peak of TNFα (P < 0.05) and IL-6 (P < 0.01). Chronic administration of ICH3 to DIO mice was associated with lower numbers of CD8+ T cells (P < 0.05) and to changed WAT expression of inflammatory factors (Hp, P < 0.05; CD301/MGL1, P < 0.01; Arg-1, P < 0.05). As compared to untreated, ICH3 DIO mice exhibited improved insulin signaling in the skeletal muscle (P < 0.01) mirrored by an improved response to glucose load (ipGTT: P < 0.05 at 120 min). Conclusions: We proved that ICH3 is an anti-inflammatory drug, able to reduce inflammatory cytokines in human adipocytes and to blunt the effects of obesity on WAT inflammatory profile, on glucose tolerance and on tissue insulin sensitivity
The Relation Between Dietary Change and Rising U.S. Obesity
No full textFood Consumption/Nutrition/Food Safety, Health Economics and Policy,
Spinal cord injury and outdoor experiences
No full textAnecdotal evidence from spinal cord injury (SCI) rehabilitation clients suggests that nature experiences and outdoor pursuits are valued ingredients in a SCI rehabilitation program, in particular for those individuals who were outdoor enthusiasts pre-injury and/or who sustained their injury during outdoor pursuits. Model SCI centres in North America offer outdoor activities as components of SCI rehabilitation. A literature review on the effects and dynamics of nature experiences and outdoor pursuits in SCI rehabilitation and adjustment reveals a lacuna of empirical research in this area. Studies on leisure and recreation following SCI offer insights into how nonvocational rehabilitation activities assist functional independence, quality of life, and community re-integration. Systematic research is needed to ascertain the value and contribution of outdoor experiences in SCI rehabilitation; further, research is needed to document how contact with 'blue-green nature' may assist in the identity reconstruction process and in adjustment to life with a physical disability.PT: J; CR: BERINGER A, 2000, 2 INT ADV THER C AUG BROWN M, 2002, TOPICS SPINAL CORD I, V7, P83 BROZLY H, 1987, STORIES SICKNESS CALDWELL LL, 1994, ANN THERAPEUTIC RECR, V5, P13 CARLSON D, 2002, TOPICS SPINAL CORD I, V7 CARPENTER C, 1994, PHYS THER, V74, P11 COYLE CP, 1990, THERAPEUTIC RECREATI, V24, P64 COYLE CP, 1993, THERAPEUTIC RECREATI, V27, P239 COYLE CP, 1994, REHABIL PSYCHOL, V39, P95 CUSHMAN L, 1991, J REHABIL, V57, P35 DATTILO J, 1998, THERAPEUTIC RECREATI, V32, P13 DIJKERS M, 2002, TOPICS SPINAL CORD I, V7 DUFF K, 1994, ALCHEMY ILLNESS FOUGEYROLLAS P, 2002, TOP SPINAL CORD INJ, V7, P1 FRUMKIN P, 2001, AM J PREV MED, V20, P234 GOLDSTEIN M, 1996, THESIS NEW YORK U GORDON WA, 1997, AM REHABILITATIONM, V23, P11 HANNAFORD S, 1985, LIVING OUTSIDE INSID HENDERSON KA, 1994, THERAPEUTIC RECREATI, V28, P73 HENDERSON KA, 1995, RES Q EXERCISE SPORT, V66, P151 KAHN PH, 2002, CHILDREN NATURE KENDALL E, 1998, J REHABIL, V64, P16 KIDNER DW, 1994, ENVIRON ETHICS, V16, P359 KLEIBER DA, 1995, J LEISURE RES, V27, P283 LAUWERS V, 2003, PARASAIL VISION QUES LEE Y, 1993, THERAPEUTIC RECREATI, V27, P200 LEE Y, 1996, J PHYS ED RECREATION, V67, P64 LEE Y, 1996, LEISURE SCI, V18, P209 LEE Y, 1999, THERAPEUTIC RECREATI, V33, P122 LYONS RF, 1987, J LEISURABILITY, V14, P4 LYONS RF, 1991, ADV PERSONAL RELATIO, V3, P233 LYONS RF, 1993, CANADIAN J REHABILIT, V6, P256 LYONS RF, 1995, RELATIONSHIPS CHRONI MACDONALD W, 1999, ONE STEP MCAWEENEY MJ, 1996, J REHABIL, V62, P29 METZNER R, PLACE STORY BIOREGIO MONTGOMERIE A, 1999, ABILITIES, V39, P46 MOORE T, 1991, CRY DAMAGED MAN MURPHY RF, 1987, BODY SILENT NELSON AL, 1990, SCI NURS, V7, P44 NELSON AL, 1990, THESIS U FLORIDA NOREAU L, 2002, TOPICS SPINAL CORD I, V7 NOSEK MA, 2001, J REHABIL, V67, P20 OSKAMP S, 2000, AM PSYCHOL, V55, P496 PASEK PB, 1995, AM J OCCUPATIONAL TH, V50, P24 ROHE DE, 1996, TOPICS SPINAL CORD I, V2 SACKS O, 1984, LEG STAND SACKS O, 1985, MAN WHO MISTOOK HIS SACKS O, 1990, AWAKENINGS SEYMOUR W, 1989, BODILY A LTERATIONS SEYMOUR W, 1998, REMAKING BODY REHABI SHIRADO O, 1995, AM J PHYS MED REHAB, V74, P408 SPENCER J, 1995, AM J OCCUP THER, V49, P53 STERN PC, 2000, AM PSYCHOL, V55, P523 STILGOE JR, 2001, AM J PREV MED, V20, P243 TAYLOR LPS, 1996, AM J OCCUP THER, V50, P39 TRIESCHMANN R, 1988, SPINAL CORD INJURIES TRIESCHMANN RB, 1992, PARAPLEGIA, V30, P58 WEBRE AW, 1990, CANOEING KAYAKING PE WELLMAN MR, 1996, CLIMBING BACK WINTER DDN, 2000, AM PSYCHOL, V55, P516; NR: 61; TC: 1; J9: INT J REHABIL RES; PG: 9; GA: 809XESource type: Electronic(1
Sequence stratigraphic model for repeated “butter shale” Lagerstätten in the Ordovician (Katian) of the Cincinnati region, USA
No full textThe “butter shale” Lagerstätten of the Cincinnati Arch have produced an abundance of articulated trilobites, along with assorted bivalves and cephalopods. These bluish-gray shales are rich in clay, poorly calcified, and show vague internal bedding in outcrop. “Butter shales” form a repetitive motif with similar lithological and paleontological characteristics suggesting conditions existed that can be explained by the interference between different orders of sequence stratigraphic cyclicity. The characteristics that define "butter shales" include: rarity of coarser interbeds, homogenous, fine grain-size, and abundance of burial horizons. The overriding control is siliciclastic sediment supply. During 3rd order transgressions sediment supply to the basin is too low to produce thick shale-prone intervals. Conversely, during third-order falling stages sediment supply is generally too high to favor "butter shale" deposition. “Butter shales” formed preferentially during 3rd order HST and two subtly different variants resulted from the superimposed effects of higher order cycles. Highstands moderated by small-scale transgressions are characterized by lower background sedimentation and fewer/thinner mud deposition events. Superposition of small-scale sea level fall on highstands produced increased background sedimentation, higher silt, and patchy fossil occurrences. Juxtaposition of various scaled HSTs provided the optimal “butter shale” conditions, characterized by elevated mud influx and frequent episodic burial events, leading to abundant, articulated trilobites and associated fauna.
In these scenarios, episodic events provide sufficient mud to smother local faunas and create a soft, fine-grained substrate that prohibited recolonization by taxa adapted to firm substrates. Each scenario differs from the others with respect to sedimentology and faunal composition.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author
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