3,578 research outputs found
Ahmed Hussein, F. A. Devillanova, F. Isaia, G. Verani Copper(I) complexes with N-methylbenzothiazole-2-thione and -2-selone. Transit. Metal Chem., 1985, 10, 368.
No full textN-methylbenzothiazole-2-thione (bttme) and -2-selone (btseme) form complexes with CuX 2 (X=Cl, Br, NO 3, 1/2SO 4 or BF 4). The reaction, carried out in MeOH, produces complexes of copper(I), whose stoichiometry mainly depends on the ligand. Infrared evidence shows that the coordination occurs through the exo-sulphur and selenium atoms
Methylmercury(II) Derivatives of Pyridine-2(1H)-thione
No full textMethylmercuric nitrate reacts with pyridine-2(lH)-thione (C5H5NS) in acetone to give methyl(pyridine-2(1H)-thione)mercury(II) nitrate, [MeHg(C5H5NS)]NO3. This complex reacts with sodium bicarbonate in acetone to give methyl(pyridine-2-thiolato)mercury(II), MeHg(C5H4NS). Infrared, Raman, and nuclear magnetic resonance spectra indicate that MeHg(II) is bonded to sulphur in both complexes, and that protonation of nitrogen occurs on reaction of MeHg(C5H4NS) with nitric acid to give [MeHg(C5H5NS)]NO3
A New Approach to 4-Alkylthio-1,3-dithiole-2-thione: An Unusual Reaction of a Zinc Complex of 1,3-Dithole-2-thione-4,5-dithiolate
No full textA new and facile approach to 4-alkylthio-1,3-dithiole-2-thione starting from easily accessible reactants was described. This approach was
based on the unusual reaction of a zinc complex of 1,3-dithiole-2-thione-4,5-dithiolate with electrophilic reagents in the presence of 3-picolyl
chloride hydrochloride/or 4-picolyl chloride hydrochloride/or pyridine hydrochloride
Highly Efficient and Stereoselective Construction of Dispiro-[oxazolidine-2-thione]bisoxindoles and Dispiro [imidazolidine-2-thione]bisoxindoles
No full textAn efficient and stereoselective reaction between 3-isothiocyanato oxindoles and isatins/isatinimines has been developed to afford structurally diverse dispiro[oxazolidine-2-thione]bisoxindoles and dispiro[imidazolidine-2-thione]bisoxindoles in excellent results under mild conditions. The potential of asymmetric induction by means of a chiral auxiliary was explored. The isomers are separable, and products could be isolated as single diastereomers by column chromatography. Further synthetic transformations of the reaction product were also successfully realized
A Selective Imidazoline-2-thione-Bearing Two-Photon Fluorescent Probe for Hypochlorous Acid in Mitochondria
No full textHypochlorite
(OCl–) plays a key role in the immune
system and is involved in various diseases. Accordingly, direct detection
of endogenous OCl– at the subcellular level is important
for understanding inflammation and cellular apoptosis. In the current
study, a two-photon fluorescent off/on probe (PNIS) bearing
imidazoline-2-thione as an OCl– recognition unit
and triphenylphosphine (TPP) as a mitochondrial-targeting group was
synthesized and examined for its ability to image mitochondrial OCl– in situ. This probe, based on the specific reaction
between imidazoline-2-thione and OCl–, displayed
a selective fluorescent off/on response to OCl– with
the various reactive oxygen species in a physiological medium. PNIS was successfully applied to image of endogenously produced
mitochondrial OCl– in live RAW 264.7 cells via two-photon
microscopy
Ultrasound-assisted lipolysis of the omentum in dwarf pigs.
No full textSuccessful surgical treatment of medium degree obesity by subcutaneous liposuction has been reported in the literature. In obesity, most adipose tissue is visceral, mainly omental, and the resection of omentum is a mutilating procedure for the intestinal tract. Because of this, we planned to reduce omental adipose tissue by an apparently conservative approach: ultrasound-assisted lipolysis. The purpose of this study was to assess the feasibility and safety of this procedure in an animal experimental model, drawing clinical and autoptic patterns. We chose pigs because they are functionally analogous to humans, although they store less fat in the omentum, whose structure looks like a veil. Four male dwarf pigs were fed, since weaning, with hyperlipidic fodder. When they were eight months old, they were operated on under general anesthesia in our laboratory for experimental surgery. After laparotomy, the omentum was delivered and treated with ultrasound for 1 hour. Before and just after the sonication, biopsies were drawn from omentum and processed for histologic findings. After 50 days, the surviving animals were sacrificed and autopsied; specimens from omentum, liver, and spleen were histologically processed. Two animals died during the operation, while the two surviving animals were in good general condition. Macro and microscopic observations demonstrated that the ultrasound can liquefy omental fat, sparing its fibrous network in the immediate time; during the postoperative period, an intense inflammatory reaction developed; macroscopic observation evidenced fibrous adhesions of the omentum to the surrounding organs; the connective tissue network was thickened and the whole omentum was twisted on itself. The high mortality rate could be due either to the surgical learning curve or to casualty or to lethal effects of ultrasound on the cardiac conductive system; the inflammatory peritoneal reaction could be specifically due to ultrasound or to surgical handling
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