1,721,082 research outputs found
Endoprotesi d'anca non cementate nel grande anziano
No full textIl più importante obiettivo del trattamento delle fratture di femore del grande anziano, è quello di consentire il più precoce possibile ritorno alle attività della vita quotidiana in modo da evitare le complicanze legate all'allettamento del paziente attraverso un approccio precoce e multidisciplinare. Gli Autori espongono i risultati clinici e funzionali di 157 pazienti tra gli 85 e 100 anni operati per frattura sottocapitata di femore con endoprotesi non cementate tra gennaio 2000 e dicembre 2005. I risultati ottenuti sono stati molto soddisfacenti
Aspetti biologici dei secondarismi ossei
No full textIn a review of the literature the authors analyze the mechanism of bone metastases in its phases: the separation of tumor cells from the primary mass, the vascular invasion, the transport, the endothelial attachment, the exit of tumor cells from the vessels, the establishing of a metastasis in the bone structure, the active bone resorption and/or the increased bone formation as a response of bone tissue. Also the factors responsible for bone reactions to tumor invasion, both lytic and blastic, have been analyzed. The active bone resorption is made by: osteoclastic activation, the quantitative predominant mechanism, and direct production of osteolytic enzymes by tumor cells. The factors activating osteoclasts are various: PTH related proteins, prostaglandins, osteoclastic activating factors, identified as interleukin 1, transforming growth factors α and β, tumor necrosis factors, linfotoxine. The bone formation is principally due to a osteoblastic activation by some factors: piezoelectric stimuli, TNF-β, PDGF, some interleukins and prostaglandins with diphasic action. A direct ossification of the stroma of some tumors, prostate and breast, in presence of osteoblasts, is also possible. Finally the use of some indicators of bone metabolism for the diagnosis of bone metastases has been reported
Biological aspects of bone metastases
No full textIn a review of the literature the authors analyze the mechanism of bone metastases in its phases: the separation of tumor cells from the primary mass, the vascular invasion, the transport, the endothelial attachment, the exit of tumor cells from the vessels, the establishing of a metastasis in the bone structure, the active bone resorption and/or the increased bone formation as a response of bone tissue. Also the factors responsible for bone reactions to tumor invasion, both lytic and blastic, have been analyzed. The active bone resorption is made by: osteoclastic activation, the quantitative predominant mechanism, and direct production of osteolytic enzymes by tumor cells. The factors activating osteoclasts are various: PTH related proteins, prostaglandins, osteoclastic activating factors, identified as interleukin 1, transforming growth factors α and β, tumor necrosis factors, linfotoxine. The bone formation is principally due to a osteoblastic activation by some factors: piezoelectric stimuli, TNF-β, PDGF, some interleukins and prostaglandins with diphasic action. A direct ossification of the stroma of some tumors, prostate and breast, in presence of osteoblasts, is also possible. Finally the use of some indicators of bone metabolism for the diagnosis of bone metastases has been reported
Problemi medici e chirurgici dei pazienti anziani in ortopedia
No full textThe world-wide medical researches are agreed to point up the importance of all the problems concerning the old age. Considering that, the authors of the text deal with the new therapeutic methods for the old, according to their peculiar orthopaedic studies
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