80 research outputs found
Platelet-Rich Fibrin in Non-Surgical Periodontal Therapy: A Split-Mouth Randomized Controlled Clinical Trial
No full textThis clinical trial investigated the efficacy of platelet-rich fibrin (PRF) as an adjunct to conventional scaling and root planing (SRP) in non-surgical periodontal therapy. In a split-mouth randomized controlled trial with 13 patients and 26 periodontal pocket sites, PRF was inserted in test group pockets alongside SRP, while control group pockets received SRP alone. Measurements at baseline and six weeks included probing pocket depths (PPDs), clinical attachment loss (CAL), gingival recession (GR), the plaque index, and the gingivitis index. The wound healing index was assessed at six weeks. The results show statistically significant improvements in the SRP+PRF group compared to SRP alone, demonstrating a better CAL gain (SRP+PRF group: 2.69 ± 0.63; SRP alone group: 4.15 ± 0.69—p-value: 0.001), PPD reduction (SRP+PRF group: 2.62 ± 0.65; SRP alone group: 3.85 ± 0.80—p-value: 0.001), and GR minimization (SRP+PRF group: 0.46 ± 0.62; SRP alone group: 0.81 ± 0.72—p-value: 0.21). The adjunctive use of PRF enhanced healing, reduced pocket depths, decreased tissue morbidity, and minimized gingival recession. This study concludes that PRF placement is effective in 5–6 mm pockets, potentially reducing the number of periodontal treatment sessions needed for pocket closure
A framework for complexity cost modelling of ERP implementation
Get PDFThe aim of this research is to develop a framework to predict the cost of the
resource complexities inherent in an ERP implementation. The framework
comprises two phases namely complexity assessment, and dynamic cost
estimation for resource complexity using agent-based modelling. The
complexity assessment phase involves complexity identification, uncertainty
evaluation for the complexity estimates, complexity assessment, complexity
classification, and complexity correlation reporting. The framework is
automated in a tool known as Complexity of Resource and Assessment Costing
Tool (C-REACT).
A number of activities have been undertaken in order to develop the ERP
resource complexity framework. Firstly, a detailed literature review was
performed in order to gain a contextual understanding of ERP implementation
challenges and complexities. Secondly, a case study analysis was conducted
to establish the current industrial practices concerning ERP implementation
challenges. Thirdly, a framework was developed and validated to identify,
assess and cost ERP complexity for each resource.
The key contribution of the framework is to introduce a new cost estimation
process to support ERP project cost estimation by predicting the cost of ERP
resource complexities, and a new process to identify, assess and control ERP
complexities inherent in the implementation stage. This framework should be
used in the needs identification stage of an ERP project lifecycle. The estimate
will inform an organisation of the potential costs of ERP resources from a
complexity perspective, thereby enabling them to make informed decisions on
ERP implementation complexity and cost reduction. Knowledge of potential
complexities will also aid the elimination of substantial errors during
implementation. Hence the organisation will yield benefits which they would not
otherwise reap in the face of complexity
A Study on Android Application Development
Get PDFAs and when the world moves towards the hand-held devices, there should be an innovation as well as awareness of such kind of application development used for the hand-held device. As time elapses the world started moves on the fingers using such kind of developed applications. In this paper we discuss the most fundamental attributes and crucial steps followed to create a robust application using Android OS. This kind of contribution will help a lot to the initiators who want to switch-over from other technologies to the mobile application development
Physiological Gingival Melanin Hyperpigmentation Treatment with Injectable Vitamin C and Scalpel Technique: A Randomised Controlled Clinical Trial
No full textHarmony between facial complexion and gingival health goes hand in hand. Gingival depigmentation is an aesthetic correction of hyperactive melanocytes in gingival tissues that lead to hyperpigmentation. Current study compares depigmentation, pain scores, and itching with scalpel technique and nonsurgical intramucosal Vitamin C injection. 30 individuals in the age range of 18–40 years conscious of dark gums were randomly allocated to test and control group by lottery method. Torough Phase I therapy was performed one week before the procedure. Area and intensity of depigmentation were evaluated preoperatively and postoperatively; pain score, itching, and repigmentation percentage were the postoperative parameters. After 24 hrs, test group showed signifcantly lesser VAS score for pain as compared to control group. Tere was no statistically signifcant diference in preoperative area of pigmentation between the test and control group (p = 0.936). Postoperatively also, there was no statistically signifcant diference in area of pigmentation between the test and control group (p = 0.932). For comparing area of pigmentation, an independent t-test was applied and Mann–Whitney test was used for diferentiating the intensity of pigmentation, repigmentation, and VAS score between the groups. Te study concluded that Vitamin C mesotherapy and scalpel technique showed comparable results in reduction of areas and intensity of gingival hyperpigmentation. Copyright © 2023 Dhanashree S. Chaudhary et al
Study, Survey and Analysis for Media Selection
No full textThis paper is a literature review on practical techniques and rules using PowerPoint, animation, and video effectively for instruction. Instruction may be teaching, training, coaching, tutoring, schooling etc. This paper must be of awareness to mentors and instructional technology staff who support faculty members in the development of instructional media. Main objective of this paper is to identify and select the proper technologies for enhancing a particular pedagogy or learning goal. Choose media that support instructor’s activity
Exposomes to Exosomes: Exosomes as Tools to Study Epigenetic Adaptive Mechanisms in High-Altitude Humans
No full textHumans on earth inhabit a wide range of environmental conditions and some environments are more challenging for human survival than others. However, many living beings, including humans, have developed adaptive mechanisms to live in such inhospitable, harsh environments. Among different difficult environments, high-altitude living is especially demanding because of diminished partial pressure of oxygen and resulting chronic hypobaric hypoxia. This results in poor blood oxygenation and reduces aerobic oxidative respiration in the mitochondria, leading to increased reactive oxygen species generation and activation of hypoxia-inducible gene expression. Genetic mechanisms in the adaptation to high altitude is well-studied, but there are only limited studies regarding the role of epigenetic mechanisms. The purpose of this review is to understand the epigenetic mechanisms behind high-altitude adaptive and maladaptive phenotypes. Hypobaric hypoxia is a form of cellular hypoxia, which is similar to the one suffered by critically-ill hypoxemia patients. Thus, understanding the adaptive epigenetic signals operating in in high-altitude adjusted indigenous populations may help in therapeutically modulating signaling pathways in hypoxemia patients by copying the most successful epigenotype. In addition, we have summarized the current information about exosomes in hypoxia research and prospects to use them as diagnostic tools to study the epigenome of high-altitude adapted healthy or maladapted individuals
Tyrosine kinase inhibitors with antiangiogenic properties for the treatment of non-small cell lung cancer
No full textLSC Abstract – Histone deacetylase 7 mediated metabolic remodeling: A new crosslink between pulmonary hypertension and cancer
No full textLSC Abstract – Histone deacetylase 7 mediated metabolic remodeling: A new crosslink between pulmonary hypertension and cancer
No full textClassical IL-6 signaling: a promising therapeutic target for pulmonary arterial hypertension
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