406 research outputs found

    Nanoemulsion technology for sublingual delivery of Melatonin : Characterization and Preliminary Data of absorption

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    Melatonin (5-methoxytryptamine) is a natural occurring molecule which exerts physiologic role of circadian sleep-wake cycle in humans. Melatonin is secreted from the pineal gland placed i the center of the brain, far from blood-brain barrier. Thanks to its ascertained safety in humans and low cost, melatonin is widely employed in the market of drugs and nutritional supplements mainly claiming its effectiveness in sleep-wake cycle regularization, anxiolytic and antioxidant activity. Over the last decades, melatonin bioavailability has been investigated in humans and animal models. Literature data pointed out a limited bioavailability of malatonin after oral intake, together withah high variability from subject to subject

    Teaching a foreign language with Internet technologies

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    Rusanova, L. I. Teaching a foreign language with Internet technologies // INTERNATIONAL SCIENTIFIC INNOVATIONS IN HUMAN LIFE Proceedings of V International Scientific and Practical Conference Manchester, United Kingdom 17-19 November 2021 Manchester, United Kingdom 2021 P. 316-322Стаття присвячена використанню Інтернет-технологій, які вважаються ідеальним засобом у навчанні іноземних мов у сучасному суспільстві. Визначено функціональний та орієнтований на студента підходи до знань. Підкреслено роль комп’ютерних технологій, особливо Інтернету та пов’язані з ним засоби масової інформації у викладанні та вивченні іноземних мов.The article is devoted to the use of Internet technologies that are considered an ideal aid in teaching foreign languages in a modern society. Learner-centered and functional approaches to knowledge are determined. The role of computer technology especially the Internet and its associated media in teaching and learning foreign languages are emphasized

    Effective intranasal GCS application strategy of mono and combines forms in treating patients, suffering from allergic rhinitis. Evidence-based medicine to help a practitioner

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    To summarize effective intranasal glucocorticosteroids (GCS) application strategies in treatment of patients, suffering from allergic rhinitis (depending on disease type), based on actual research results. Current study determines the place of fixed intranasal GCS and topic antihistamine medication combination, specifically azelastine and mometasone furoate, as a first line of choice therapy in treatment of patients, suffering from allergic rhinitis. Effective application of stage therapy allows us establish control over allergic inflammation and significantly decrease pharmaceutical load in cases of patients, suffering from allergic rhinitis. © N.S. TATAURSHCHIKOVA, PV. BEREZHANSKIY, A.S. RUSANOVA

    Defining a prognostic criterion of orthopaedic complications development in patients with an injury of anterior cruciate ligament of knee joint

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    Rusanov A, Roy I, Rusanova O. Defining a prognostic criterion of orthopaedic complications development in patients with an injury of anterior cruciate ligament of knee joint. Physiotherapy Quarterly. 2019;27(3):34-38. doi:10.5114/pq.2019.87596.Introduction Prognostic indices of orthopaedic implications development were investigated among patients with anterior cruciate ligament (ACL) injuries on the basis of stabilography research during the functional period of rehabilitation. Methods The study included 52 randomly selected individuals with a complete ACL tear qualified for surgical reconstruction. The patients’ age was 18–59 (average: 37.8 ± 2.0) years. All participants underwent rehabilitation treatment in the Institute of Traumatology and Orthopaedics, National Academy of Medical Sciences of Ukraine, and had surgeries in the Institute’s clinics. The crural part of the graft was fixed with the assistance of either the RigidFix system or the Cross-Pin system, and the Biointrafix or Biosure Sync system was applied for the tibial part. Results and conclusions On the basis of the performed analysis of indices that characterize the functional condition of the injured limb of patients with an injury of ACL of knee joint at the functional stage of rehabilitation treatment, it is possible to identify a high and medium level of loading asymmetry in the lower extremities, decrease of electrobiological activity and muscle resistance ability during bending, stretching, adduction, and abduction, as the main prognostic criterion of orthopaedic complications development

    Exploring the Impact of Contaminants of Emerging Concern on Fish and Invertebrates Physiology in the Mediterranean Sea

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    In this historical context, the Mediterranean Sea faces an increasing threat from emerging pollutants such as pharmaceuticals, personal care products, heavy metals, pesticides and microplastics, which pose a serious risk to the environment and human health. In this regard, aquatic invertebrates and fish are particularly vulnerable to the toxic effects of these pollutants, and several species have been identified as bio-indicators for their detection. Among these, bivalve molluscs and elasmobranchs are now widely used as bio-indicators to accurately assess the effects of contaminants. The study focuses on the catshark Scyliorhinus canicular and on the Mediterranean mussel Mytilus galloprovincialis. The first one is a useful indicator of localised contamination levels due to its exposure to pollutants that accumulate on the seabed. Moreover, it has a high trophic position and plays an important role in the Mediterranean Sea ecosystem. The bivalve mollusc Mytilus galloprovincialis, on the other hand, being a filter-feeding organism, can acquire and bioaccumulate foreign particles present in its environment. Additionally, because it is also a species of commercial interest, it has a direct impact on human health. In conclusion, the increasing presence of emerging pollutants in the Mediterranean Sea is a serious issue that requires immediate attention. Bivalve molluscs and elasmobranchs are two examples of bio-indicators that must be used to precisely determine the effects of these pollutants on the marine ecosystem and human health

    Constructive and destructive role of a symbol as an object of cultural identity in the globalization process

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    The object of the present study presents problematic processes of globalization and cultural identity. The subject of study is the symbol as an object of cultural identity within the framework of the transformation of value-semantic sphere of the person under the influence of globalization. The author examines such aspect as the problem of "Westernization" of cultural property in Russia, which entails a correlation of values of the individual in accordance with the axiological and symbolic forms that are postulated by modern media. The author pays attention to the fact that in order to preserve the cultural identity and unity of Russian the society should pay attention to the processes of globalization, which have a certain set of templates and stamps, symbolic series and images that manipulate a person at a subconscious level, investing in the ideological structure of human specific patterns of behavior and thinking. The goal of the study is to analyze the symbol as an object of cultural identity in the globalization processes

    How does training of the working memory effect the memory performance in young people?

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    One of the quality indicators of the medical education is a good study performance, which is very much influenced by the capacity of the working memory. Recent studies have reported that working memory can be improved by training. In this study, we were looking for association between the training of the working memory and its performance in healthy students at Kazakh National Medical University. A total of 676 students participated: 346 in study group and 346 – in control. Reading span test (RST) was used for working memory training and Dual N-back test was used for measurement of results. According to the results obtained, one-and-a-half-month RST training of the memory (RAM) statistically significantly increases the amount of the working memory on average by 12.3 %: min on 9.9 %; max on 15.5 % (р<0.001). Тhe present study examined the relationship of the working memory training and increase in its level in healthy young adults. Our findings indirectly confirm that training not only increases the level of the working memory, but also stimulates other cognitive functions: improving auditory and spatial memory in parallel to the visual one

    Self-directed learning as a necessary component of the educational process in studying a foreign language at higher education institutions institutions

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    Sazanova, L. S. Self-directed learning as a necessary component of the educational process in studying a foreign language at higher education institutions institutions / Sazanova L. S., Rusanova L. I. // Іноземна мова у формуванні професійної іншомовної компетентності студентів ЗВО: тези доп. Міжуніверситетського наук.-практ. семінару (з нагоди 20-річчя заснування кафедри) / МОН України, Нац. юрид. ун-т імені Ярослава Мудрого, Каф. інозем. мов №2. - Харків, 2019. - С. 166-169.У статті обговорюється декілька теорій навчання дорослих і важливість самостійного навчання саме тому, що дорослі беруть активну участь у процесі. В статті говориться, що навчання має базуватися на повазі, взаєморозумінні, співпраці та неформальному комфортному оточенні.Several adult learning theories and the importance of self-directed learning for adults who are actively involved in learning are discussed in the article. It is said that learning should be based on respect, mutual understanding, cooperation, and informal comfortable surroundings.В статье обсуждаются несколько теорий обучения взрослых и важность самостоятельного образования именно потому, что взрослые принимают активное участие в процессе. В статье говорится, что обучение должно основываться на уважении, взаимопонимании, сотрудничестве и неформальном комфортном окружении
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