1,721,247 research outputs found
Experiential-Walk: Experiencing and Representing the City for Urban Design Purposes
No full textThis contribution presents an experimental methodology for sensing and communicating the city for urban design purposes. More in detail, the goal of the experiential-walk method developed by the author is mainly directed at improving the designer's attitude and ability in considering the multisensory and dynamic environmental conditions from the very beginning of the design process thanks to a personal immersion in motion and in place. The methodology consists of three main phases: i) direct experience and observation, ii) self-reflection and interpretation, iii) data collection, representation and communication. The aim of the first phase is to feel what the place is and what the place might be or what the place is in nuce. The second phase is about mulling over the experience and interpreting the nature of the place. The last phase is directed at representing and communicating the experience and the place criticalities and potentialities. The entire (recursive) process can be intended as a sequence of interconnected actions to increase sensory awareness. It eventually aims at discovering and sharing the said and the unsaid of places. Besides the methodology description, some case studies applications and results are presented together with the lessons learned
Il concetto di invalido nei paesi della C.E.E.: note preliminari. L'invalido "civile" nel Regno Unito ed in Italia
No full textCurrent status in iron chelation in hemoglobinopathies
No full textAlthough blood transfusions are important for patients with hemoglobinopathies, chronic transfusions inevitably lead to iron overload as humans cannot actively remove excess iron. The cumulative effects of iron overload lead to significant morbidity and mortality, if untreated. Desferrioxamine (DFO) is the reference-standard iron chelator whose safety and efficacy profile has been established through many years of clinical use. DFO side effects are acceptable and manageable however the prolonged subcutaneous infusion regimen of 5-7 days per week is very demanding and results in poor adherence to therapy. Deferiprone (Ferriprox, L1) is a bidentate molecule, orally administrable three-times/day, licensed in Europe and in other regions but in the USA and Canada, for the treatment of iron overload in patients for whom DFO therapy is contraindicated or inadequate. Preliminary evidences suggest that Deferiprone may be more effective than DFO in chelating cardiac iron. The side effects include gastrointestinal symptoms, liver dysfunction, joint pain, neutropenia and agranulocytosis. A weekly assessment of white blood cell counts is recommended because of the risk of agranulocytosis. Deferasirox is a new, convenient, once-daily oral iron chelator that has demonstrated in various clinical trials good efficacy and acceptable safety profile in adult and pediatric patients affected by transfusion-dependent thalassemia major and by different chronic anemias (SCD, BDA, MDS). The long half-life of Deferasirox (16-18 hours) provides sustained 24 hr iron chelation coverage. The efficacy and safety profile have been evaluated in more than 1000 patients in clinical trials allowing FDA registration. Patient satisfaction with Deferasirox was superior than with DFO therapy
Riflessioni sul ruolo del medico-legale in un Centro di Soccorso Violenza Sessuale
No full textGli Autori si soffermano sugli aspetti medico-legali dell'accoglienza della vittima di violenza, alla luce dell'esperienza maturata durante dieci anni di attività nel Soccorso Violenza Sessuale di Milano
Riflessioni sul ruolo del medico-legale in un Centro di Soccorso Violenza Sessuale – SVS
No full textL'attività del medico di medicina generale : aspetti medico-legali e deontologici
No full textLa finalità di questo opuscolo è quella di offrire, attraverso la trasmissione della esperienza e della dottrina medico-legale, utili ed efficaci strumenti di lavoro ai MMG
Farmaco branded vs farmaco generico: responsabilità uguali o diverse per il medico?
No full textI docenti affrontano i diversi profili di responsabilità per il medico nell'attività prescrittiva, in particolare di un farmaco branded vs generic
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