149 research outputs found
Marcello Zicàri, Scritti Catulliani, a cura di Piergiorgio Parroni
No full textLiénard Edmond. Marcello Zicàri, Scritti Catulliani, a cura di Piergiorgio Parroni. In: L'antiquité classique, Tome 49, 1980. pp. 370-371
Lo spazio letterario di Roma antica. VII. I testi: 2. La prosa
No full textDescrizione dei contenuti e dell'evoluzione dei principali generi letterari della letteratura latina in prosa, illustrati da esempi particolarmente significativi offerti da brani scelti, tradotti e annotati. Degli autori antologizzati si presentano dettagliati capitoli bio-bigliografic
Lo spazio letterario di Roma antica. VI. I testi: 1. La poesia
No full textDescrizione dei contenuti e dell'evoluzione dei principali generi letterari della letteratura latina in versi, illustrati da esempi particolarmente significativi offerti da brani scelti, tradotti e annotati. Degli autori antologizzati si presentano dettagliati capitoli bio-bigliografic
Suicide by burning
No full textThrough a review of the Italian and international scientific literature, the Authors analyse the phenomenon of suicide by burning. By references to cases in the literature, they analyse parameters of an epidemiological statistics nature (sex and age of the victims, place and means of performing the act) as well as the motives that may be hidden behind such an event. The cultural and historical factors that influence suicide by burning are analysed, with emphasis on the psychiatric history, which currently seems to play a fundamental role in the victim's choice of means. This work is an initial approach to the study of the phenomenon of suicide by burning and is an essential preliminary to a review of the cases in the anatomical- pathological section of the Institute of Forensic Medicine at the 'La Sapienza' University of Rome
Premessa
No full textSi descrive l'attività scientifica e di insegnamento di Piergiorgio Parroni. Si interpreta la frase del "De syllabis" di Terenziano Mauro che dà il titolo al libro (v. 1287 "et labor in studiis semper celebratus inhaeret") e si segnala il precedente in Quintiliano, inst. 3, 6, 65
Sebastiano Timpanaro - Scevola Mariotti. Carteggio (1944-1999)
No full textEdizione commentata dell'intero carteggio conservato tra i filologi italiani Sebastiano Timpanaro (1923-2000) e Scevola Mariotti (1920-2000). Composto da un corpus di 640 lettere – a partire dal 1944, quando Sebastiano Timpanaro e Scevola Mariotti erano brillanti studenti universitari –, questo volume rappresenta un monumento della filologia italiana negli anni Cinquanta-Settanta del Novecento. Documento di un’amicizia profonda, il volume raccoglie discussioni intense e assai vivaci su problemi ecdotici di particolare rilevanza per la conoscenza della tradizione classica
Use of the secreted proteome of Trametes versicolor for controlling the cereal pathogen Fusarium langsethiae
No full textFusarium langsethiae is amongst the most recently discovered pathogens of small grains cereals. F. langsethiae is the main producer, in Europe, of T2 and HT-toxins in small grain cereals, albeit often asymptomatic; this makes its control challenging. The European Union (EU) is pushing hard on the use of biocontrol agents to minimize the use of fungicides and pesticides, which are detrimental to the environment and responsible for serious pollution of the soil and superficial water. In line with EU directives (e.g., 128/2009), here we report the use of protein fractions, purified from the culture filtrate of the basidiomycete Trametes versicolor, for controlling F. langsethiae. T. versicolor, a so-called medicinal mushroom which is applied as a co-adjuvant in oncology and other pathologies as a producer of biological response modifiers. In this study, the exo-proteome of T. versicolor proved highly efficient in inhibiting the growth of F. langsethiae and the biosynthesis of the T2 toxin. Results are promising for its future use as a sustainable product to control F. langsethiae infection in cereals under field conditions
Structural stability of cold-adapted serine hydroxymethyltransferase, a tool for ß-hydroxy-α-amino acid biosynthesis
No full textSerine hydroxymethyltransferase (SHMT) is a pyridoxal-5'-phosphate-dependent enzyme that catalyses the reversible conversion of l-serine and tetrahydropteroylglutamate to glycine and 5,10-methylenetetrahydropteroylglutamate. This enzyme represents a good model for analysing the intricate relationship between activity and stability, since it is ubiquitous in nature and well characterized from different organisms. Besides its physiological role, SHMT catalyses the reversible cleavage of several beta-hydroxy amino acids varying in substituent and stereochemistry at C-beta and, for this reason, it represents a good tool for biotechnological applications. SHMT from the psychrophilic bacterium Psychromonas ingrahamii (piSHMT) displays the interesting feature of having high specific activity in the cleavage of beta-hydroxy amino acids at all temperatures. In the present study, we compare the temperature dependence of psychrophilic piSHMT and mesophilic Escherichia coli SHMT (ecSHMT) in catalysing the physiological hydroxymethyltransferase reaction. We also investigate the structural stability of both enzymes by performing equilibrium unfolding experiments. Unexpectedly, our results show that piSHMT is a less efficient catalyst than ecSHMT in the hydroxymethyltransferase activity at all temperatures. Moreover, the two enzymes have comparable structural stability, with piSHMT showing even higher resistance to chemical denaturation by urea and to inactivation by formaldehyde. This unusual structural stability of piSHMT and its high efficiency at low temperatures as catalyst of beta-hydroxy amino acids cleavage make this enzyme an attractive tool for industrial applications
Aflatoxins are natural scavengers of reactive oxygen species
No full textAbstract The role of aflatoxins (AFs) in the biology of producing strains, Aspergillus sect. Flavi, is still a matter of debate. Over recent years, research has pointed to how environmental factors altering the redox balance in the fungal cell can switch on the synthesis of AF. Notably, it has been known for decades that oxidants promote AF synthesis. More recent evidence has indicated that AF synthesis is controlled at the transcriptional level: reactive species that accumulate in fungal cells in the stationary growth phase modulate the expression of aflR, the main regulator of AF synthesis—through the oxidative stress related transcription factor AP-1. Thus, AFs are largely synthesized and secreted when (i) the fungus has exploited most nutritional resources; (ii) the hyphal density is high; and (iii) reactive species are abundant in the environment. In this study, we show that AFs efficiently scavenge peroxides and extend the lifespan of E. coli grown under oxidative stress conditions. We hypothesize a novel role for AF as an antioxidant and suggest its biological purpose is to extend the lifespan of AFs-producing strains of Aspergillus sect. Flavi under highly oxidizing conditions such as when substrate resources are depleted, or within a host
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