1,836 research outputs found
Mencarelli F., Vannini A. Postharvest handling in "Chestnut Handbook" Eds Gabriele Beccaro, Alberto Alma, Giancarlo Bounous, Jose Gomes-Laranjo, CRC Press
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Electrical conductivity of graphene: A time-dependent density functional theory study
No full textExcitation and propagation of surfaces waves in graphene are analyzed within a frequency band of 1 to 300 THz, and a time domain of 1 to 10 ps. An ab initio approach, based on time dependent density functional theory in linear response regime is used. The key outputs of the simulation are the ab-initio conductance in time and frequency. This is shown to tend to a continuous integral relations in graphene, when the valence and conduction bands is treated within the conical approximation, in agreement with a widely used construction derived from the Kubo formula. Non-negligible differences are observed between the ab-initio and continuous methods at frequencies larger than a few tens of THz, i.e., at times shorter that 0.1ps, where the conical approximation reaches its limits of validity. The main conclusion of the study is that a novel conductivity concept is introduced, which represents a fundamental improvement with respect to some commonly used methods in electromagnetic simulations, working at THz frequencies. These tools may open the way to properly analyze graphene related materials, hethero-structures and interfaces.)
Recent advances in postharvest technology of the wine grape to improve the wine aroma
No full textThis is the final version of the paper: "Recent advances in postharvest technology of the wine grape to improve the wine aroma." Published in Journal of the Science of Food and Agriculture, 201
RB1 Germline Variant Predisposing to a Rare Ovarian Germ Cell Tumor: A Case Report
No full textMalignant ovarian germ cell tumors (MOGCTs) are neoplasms of the ovary, of which, due to their rarity and heterogeneity, few is reported about genetic background and development. Here, we report a 18-years old patient diagnosed with an ovarian mixed germ cell tumor, without any previous history of malignancies, who has been treated with surgery and chemotherapy and died 4 years later due to peritoneal metastasis complications. Patient's blood DNA was screened for a panel of 52 cancer-related genes in order to identify predisposing aberrations to this rare cancer. The analysis discovered the uncharacterized c.2393G>A variant in RB1, the retinoblastoma gene, leading both to a missense change and a splicing perturbation of the RB1 transcript. The variant was found to be hypomorphic, damaging the C-terminal domain with a partially impaired protein function. The variant is inherited from the unaffected mother. Due to an imprinting mechanism, the maternal allele is ~3-fold more expressed than the paternal one. The parent-of-origin effect combined with the hypomorphic impact of the variant determines a rescue of sufficient tumor-suppressor activity to prevent retinoblastoma development but can predispose to other cancers in the adult age. In order to understand the somatic events acting on the germline predisposition we used the NGS-liquid biopsy covering 77 cancer driver genes. Using this approach, we detected deleterious mutations in TP53, SMAD4, FGFR3, and MSH2, indicative of a dis-regulation of cell cycle and DNA repair mechanisms pathways. In conclusion, we have pinpointed for the first time that an RB1 leaky variant, not leading to retinoblastoma because of its maternal origin, can predispose in adults to a very rare form of ovarian cancer and that the somatic disruption of few genes contributes to the tumor progression and aggressiveness. © 2020 Gelli, Fallerini, Valentino, Giliberti, Castiglione, Laschi, Palmieri, Fabbiani, Tita, Mencarelli, Renieri and Ariani
HALOGENOPHILIC SUBSTITUTION IN THE REACTION OF 3-METHYL-5-TRICHLOROMETHYL-1,2,4-OXADIAZOLE WITH THE PARA-TOLUENETHIOLATE ION
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