1,721,047 research outputs found
Transition from ziprasidone im to oral formulation in agitated patients with acute exacerbation of schizophrenia: an open trial
No full textIntroduction: A transition from IM to oral formulation of an antipsychotic agent is often required during the long-term management of schizophrenia. This multicenter trial evaluates the IM/oral sequential administration of ziprasidone in agitated subjects with an exacerbation of schizophrenia.
Methods: Adult patients requiring IM therapy for schizophrenic symptoms were assigned to IM ziprasidone 10 mg for 3 days, followed by oral ziprasidone (initial dose: 80 mg/day) for 8 weeks. The primary efficacy outcomes were the change in the total PANSS and in the CGI-S scores vs. baseline values.
Results: In total, 150 patients were included in the study. A decline in the PANSS and CGI-S scores was observed throughout the study (p < 0.0001 vs. baseline): these reductions became significant at the point of transition from IM to oral formulation (p < 0.0001 vs. baseline).
Discussion: Even with the limitations of any non-comparative study, these results suggest that the IM/oral sequential administration of ziprasidone is an effective and well tolerated therapeutic option in the management of acute exacerbations of schizophrenia in agitated patients
le sequele a lungo termine dell’infezione da virus respiratorio sinciziale: l’ipotesi immunogenica
No full textThe Southern Italy Neonatal Intensive Care Units Network: very low birth weight outcomes for 1994
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Gastric emptying and electrical activity in preterm newborns assuming different milk formulas
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