647 research outputs found
Training Data for "From reads to (pseudo) counts : guided step by step exploration" tutorial (Galaxy Training Material)
No full text<p>A sampled subset of reads, used in the 'From Reads to (Pseudo) Counts: Guided Step-by-Step Exploration' GNT tutorial, which covers RNA-seq analysis including:</p>
<ul>
<li>Qualitative analysis</li>
<li>Quantification of genes and transcripts (counts and pseudo-counts)</li>
<li>Assembly with reference</li>
<li>Local assembly</li>
</ul>
<p>This subset is extracted from:</p>
<p>Hélène Lopez-Maestre, Lilia Brinza, Camille Marchet, Janice Kielbassa, Sylvère Bastien, Mathilde Boutigny, David Monnin, Adil El Filali, Claudia Marcia Carareto, Cristina Vieira, Franck Picard, Natacha Kremer, Fabrice Vavre, Marie-France Sagot, Vincent Lacroix, SNP calling from RNA-seq data without a reference genome: identification, quantification, differential analysis and impact on the protein sequence, <em>Nucleic Acids Research</em>, Volume 44, Issue 19, 2 November 2016, Page e148, <a href="https://doi.org/10.1093/nar/gkw655">https://doi.org/10.1093/nar/gkw655</a></p>
EUS for the staging of gastric cancer: a meta-analysis
No full textBACKGROUND:
The role of EUS in the locoregional staging of gastric carcinoma is undefined.
OBJECTIVE:
We aimed to comprehensively review and quantitatively summarize the available evidence on the staging performance of EUS.
DESIGN:
We systematically searched the MEDLINE, Cochrane, CANCERLIT, and EMBASE databases for relevant studies published until July 2010.
SETTING:
Formal meta-analysis of diagnostic accuracy parameters was performed by using a bivariate random-effects model.
PATIENTS:
Fifty-four studies enrolling 5601 patients with gastric cancer undergoing disease staging with EUS were eligible for the meta-analysis.
MAIN OUTCOME MEASUREMENTS:
EUS staging accuracy across eligible studies was measured by computing overall sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR).
RESULTS:
EUS can differentiate T1-2 from T3-4 gastric cancer with high accuracy, with overall sensitivity, specificity, PLR, NLR, and DOR of 0.86 (95% CI, 0.81-0.90), 0.91 (95% CI, 0.89-0.93), 9.8 (95% CI, 7.5-12.8), 0.15 (95% CI, 0.11-0.21), and 65 (95% CI, 41-105), respectively. In contrast, the diagnostic performance of EUS for lymph node status is less reliable, with overall sensitivity, specificity, PLR, NLR, and DOR of 0.69 (95% CI, 0.63-0.74), 0.84 (95% CI, 0.81-0.88), 4.4 (95% CI, 3.6-5.4), 0.37 (95% CI, 0.32-0.44), and 12 (95% CI, 9-16), respectively. Results regarding single T categories (including T1 substages) and Bayesian nomograms to calculate posttest probabilities for any target condition prevalence are also provided.
LIMITATIONS:
Statistical heterogeneity was generally high; unfortunately, subgroup analysis did not identify a consistent source of the heterogeneity.
CONCLUSIONS:
Our results support the use of EUS for the locoregional staging of gastric cancer, which can affect the therapeutic management of these patients. However, clinicians must be aware of the performance limits of this staging tool
The combination of erector spinae plane block and pectoralis blocks could avoid general anesthesia for radical mastectomy in high risk patients
No full textPrinse de Terouane et Hedin
No full textÉ ed. facs. de: Brief et vray récit de la Prinse de Terouane et Hedin avec la bataille faite à Renty 1553-1554 / par Jacques Basilic Marchet. -- A Anvers, 155
La valutazione di ambienti caldo-moderati in presenza di irraggiamento solare
No full textLa tutela della salute e del benessere sono dei requisiti fondamentali, per la progettazione di mansioni e postazioni di lavoro e per la realizzazione di ambienti di lavoro. Con specifico riferimento agli ambienti termici, in letteratura sono disponibili criteri che consentono di valutare le situazioni di esposizione in ambienti usualmente definiti come caldi, moderati o freddi. Attualmente non è disponibile un unico criterio che consenta di valutare quelle situazioni intermedie che difficilmente ricadono in maniera definita in una delle precedenti categorie. Inoltre i criteri disponibili non prevedono la valutazione dell’eventuale contributo dell’irraggiamento solare, limitando così il loro campo di applicazione a situazioni di esposizioni in ambiente interno. Il lavoro degli autori è stato quindi rivolto alla elaborazione di un modello che, sulla base anche delle indicazioni di modelli disponibili in letteratura, offrisse la possibilità di valutare situazioni di esposizione in ambienti esterni moderatamente caldi, in presenza di significativo irraggiamento solare, fornendo un efficace strumento che, pur contemplando fenomeni fisici relativamente complessi, risulta di facile utilizzo e di agevole applicazione a situazioni attualmente valutabili solo in maniera approssimata
An index for evaluation of human thermal response in hot and moderate environments
No full textThe research about the evaluation of human exposure to thermal environments has been performed for a long time, nowadays making available many indices allowing us to do a complete and refined evaluation. Shortly, the followed approaches are of the two types: that one based on empirically obtained indices (WBGT, Effective Temperature etc.) and the rational one, based on human body heat balance and thermoregulatory response evaluation (PMV-PPD, New Effective Temperature, HSI, Required Sweat Rate index etc.).
Really and as a general rule, the field of application of these indices is limited to the evaluation of thermal comfort or alternatively of heat stress, being so required to use different indices for stress or comfort, not existing a single index for an evaluation in both cases.
Starting from these premises the authors propose a method for evaluating human thermal exposure with two main goals: to be used also outdoor, thus taking into account direct and not direct thermal effects of solar radiation, and to allow both the evaluation of thermal comfort and stress exposure (as required), even if with a little greater approximation than that one obtained by using the single indices
Supreme laryngeal mask airway for laparoscopic cholecystectomy in patient with severe pulmonary fibrosis
No full text
Pulmonary metastases radiologic imaging and pathologic correlation
No full textThe main problem in the treatment of pulmonary lymphangioleiomyomatosis, which frequently occurs in the reproductive age, is the control of chylothorax and disease progression. We herein report a case of a 62-year-old woman who underwent surgery for recurrent chylothorax. Histologic examination of lung and lymph node biopsies demonstrated lymphangioleiomyomatosis. Thirty-six months after tetracycline pleurodesis and high-dose medroxyprogesterone acetate therapy, the disease was stable and chylothorax effectively controlled. It would therefore appear that hormonal treatment with medroxyprogesterone acetate may be beneficial in postmenopausal wome
- …
