1,451 research outputs found
An all-analog CMOS implementation of a turbo decoder forhard-disk drive read channels
No full textIn this work we present a full analog turbo decoder for hard-disk EPR-IV read channels in CMOS technology. The design is based on a current-mode approach developed by Loeliger et al. [2001], for the analog implementation of sum-product algorithms. The circuit's main attractions are the coding gain offered by turbo codes over the uncoded EPR-IV channel, and the relative simplicity and power efficiency of the analog approach over the digital approach. The circuit is developed in a 0.18 μm CMOS technology and operates at a 1.8 V power supply, with a total simulated power consumption (including peripheral circuitry) of about 650 mW at 400 Mb/
Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na
No full textAbstract not availableMatthew J. Olnes, Aarthie Shenoy, Barbara Weinstein, Loretta Pfannes, Kelsey Loeliger, Zachary Tucker, Xin Tian, Minjung Kwak, Francois Wilhelm, Agnes S.M. Yong, Irina Maric, Manoj Maniar, Phillip Scheinberg, Jerome Groopman, Neal S. Young, Elaine M. Sloan
sj-docx-1-ict-10.1177_15347354211069885 – Supplemental material for ENhAncing Lifestyle Behaviors in EndometriaL CancEr (ENABLE): A Pilot Randomized Controlled Trial
No full textSupplemental material, sj-docx-1-ict-10.1177_15347354211069885 for ENhAncing Lifestyle Behaviors in EndometriaL CancEr (ENABLE): A Pilot Randomized Controlled Trial by Lara Edbrooke, Pearly Khaw, Alison Freimund, Danielle Carpenter, Orla McNally, Lynette Joubert, Jenelle Loeliger, Anya Traill, Karla Gough, Linda Mileshkin and Linda Denehy in Integrative Cancer Therapies</p
Coding Theory (Dagstuhl Seminar 13351)
No full textCoding theory has become an essential ingredient of contemporary information technology, and it remains a fascinating area of research.
The seminar brought together 45 high-caliber researchers with backgrounds
and interests in various different parts of coding theory. The new area of codes for cloud applications received much attention, but other key areas such as network codes, codes on graphs, algebraic coding, and polar codes, were also well represented and generated lively discussions
[Photograph 2012.201.B0362.0970]
No full textPhotograph used for a story in the Oklahoma Times newspaper. Caption: "Jeffrey Loeliger
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Implementation of a validated substance use disorder screening tool and motivational interviewing in perinatal settings to improve engagement in substance use treatment
No full textKelsey B. Loeliger, MD, PhD1, Tanya Jain, BA2, Isabel Warner, BS 2, Jessica Rivas, MD3, Rachel Pacyna, MD3, Jerasimos Ballas, MD, MPH4, Carla Marienfeld, MD5, Julia Cormano, MD3 1Division of Complex Family Planning, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Diego;2University of California, San Diego School of Medicine;3Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Diego;4Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Diego;5Department of Psychiatry, University of California, San Diego
Background
Approximately 8-11% of pregnant women have substance use disorders (SUD). Pregnancy is often a time when people are motivated to engage in SUD treatment, and treatment in pregnancy has been shown to improve both maternal and neonatal outcomes. The process by which pregnant people are screened and referred for treatment and support services can significantly impact outcomes. Although there are screening tools such as the “4 P’s Plus” that have been validated in pregnancy and already incorporated into EPIC, UCSD’s perinatal clinics and Labor & Delivery triage areas do not currently use a validated SUD screening tool. There is an unmet need for and desire among clinicians for validated SUD screening as well as training in how to constructively discuss screening results with patients and refer patients for SUD services. This project aims to: 1) incorporate a validated screening tool such as 4 P’s Plus into our routine screening workflow in clinic and triage settings and 2) train clinicians in motivational interviewing techniques to engage patients in a discussion regarding their positive screening results.
Project Description
A multidisciplinary team of physicians, residents, and medical students within Complex Family Planning, Maternal-Fetal Medicine (MFM), and Addiction Psychiatry worked to identify gaps in the clinical workflow and potential mechanisms to facilitate linkage to SUD treatment within perinatal settings. Based on the literature, a SUD screening tool validated in pregnancy will be selected to be administered alongside other routine perinatal screening tools. The results will be documented in flowsheets to inform their clinicians. Clinical note templates will also be modified to import screening results accompanied by follow-up questions to prompt referral if appropriate. EPIC medical record extraction over a three-month period will then be conducted to evaluate outcomes of interest including proportion of patients 1) with a positive screening, 2) interested in referral to an MFM for further discussion of treatment options, 3) referred to MFM, 4) seen in MFM clinic, and 5) initiated on treatment, if indicated. Long-term outcomes may include postpartum maternal and neonatal outcomes and Department of Children and Family (DCF) involvement. The educational component of this project includes training in motivational interviewing for OBGYN residents (n=24) and interested staff members to better equip clinicians to appropriate respond to a positive SUD screening and engage patients in care. This training will include a pre-training needs assessment survey, a 1-hour online module on motivational interviewing followed by a 1-hour didactic lecture by an Addiction Psychiatry specialist, and a post-training survey. Paired Wilcoxon tests of Likert scales will be used to compare pre- and post-training clinician comfort levels.
Expected Outcomes
Through the implementation of standardized, unbiased, trauma-informed, and non-stigmatizing SUD screening accompanied by motivational interviewing, we anticipate that patients with SUDs can be identified and engaged in care in a way that strengthens patient-provider relationships and improves health outcomes for the maternal-fetal dyad.
Next steps
Standardized questionnaires are currently under review for incorporation into the routine obstetric intake workflow. Once a tool has been selected, we will begin the implementation and outcomes evaluation process described above, with guidance from clinical staff and directors. 
A Systematic Approach to Adaptive Algorithms for Multichannel System Identification, Inverse Modeling, and Blind Identification
No full textaccepted on the recommendation of Prof. Dr. George S. Moschytz, examinerProf. Dr. Scott C. Douglas, co-examiner Prof. Dr. Hans-Andrea Loeliger, co-examine
Codes on Graphs, Trellises and Spatial Coupling: another look at self-concatenated convolutional codes
No full textWe present recent results on spatially coupled turbolike codes and point out a connection to the self-concatenatedtrellis construction proposed by Loeliger in 1997 [1]
Antibiotic-dependent correlation between drug-induced killing and loss of luminescence in Streptococcus gordonii expressing luciferase
No full textMeasuring antibiotic-induced killing relies on time-consuming biological tests. The firefly luciferase gene (luc) was successfully used as a reporter gene to assess antibiotic efficacy rapidly in slow-growing Mycobacterium tuberculosis. We tested whether luc expression could also provide a rapid evaluation of bactericidal drugs in Streptococcus gordonii. The suicide vectors pFW5luc and a modified version of pJDC9 carrying a promoterless luc gene were used to construct transcriptional-fusion mutants. One mutant susceptible to penicillin-induced killing (LMI2) and three penicillin-tolerant derivatives (LMI103, LMI104, and LMI105) producing luciferase under independent streptococcal promoters were tested. The correlation between antibiotic-induced killing and luminescence was determined with mechanistically unrelated drugs. Chloramphenicol (20 times the MIC) inhibited bacterial growth. In parallel, luciferase stopped increasing and remained stable, as determined by luminescence and Western blots. Ciprofloxacin (200 times the MIC) rapidly killed 1.5 log10 CFU/ml in 2-4 hr. Luminescence decreased simultaneously by 10-fold. In contrast, penicillin (200 times the MIC) gave discordant results. Although killing was slow (< or = 0.5 log10 CFU/ml in 2 hr), luminescence dropped abruptly by 50-100-times in the same time. Inactivating penicillin with penicillinase restored luminescence, irrespective of viable counts. This was not due to altered luciferase expression or stability, suggesting some kind of post-translational modification. Luciferase shares homology with aminoacyl-tRNA synthetase and acyl-CoA ligase, which might be regulated by macromolecule synthesis and hence affected in penicillin-inhibited cells. Because of resemblance, luciferase might be down-regulated simultaneously. Luminescence cannot be universally used to predict antibiotic-induced killing. Thus, introducing reporter enzymes sharing mechanistic similarities with normal metabolic reactions might reveal other effects than those expected
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Trauma Inquiry and Response: Applying the TRIADS Framework to Family Planning Care
No full textKelsey B. Loeliger, MD, PhD1, Zoe Matticks, MPH2, Hannah Begna, MSc3, Maud Arnal, PhD4, Eleanor Bimla Schwarz, MD, MS3, Megha Shankar, MD5
1
Division of Complex Family Planning, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Diego
2
University of California, San Diego School of Medicine
3
Department of Medicine, University of California, San Francisco
4
Department of Sociology, Herbert Wertheim School of Public Health & Human Longevity Science, University of California, San Diego
5
Department of Medicine, University of California, San Diego
Background:
Although people seeking family planning services are often at risk for trauma, there are no clear clinical guidelines around trauma screening, inquiry, and response in family planning settings. The Trauma and Resilience-informed Inquiry for Adversity, Distress, and Strengths (TRIADS) framework emphasizes an empathetic, respectful, and equity-based approach of addressing trauma. This project 1) identifies training needs in family planning settings regarding trauma inquiry and response, and 2) evaluates whether the TRIADS framework can be effectively applied to meet these needs.
Methods:
We conducted an online survey of first-year family planning fellows nationally to assess baseline comfort in trauma inquiry and response. We then conducted a narrative literature review and environmental scan on trauma inquiry and response in reproductive health settings. Findings were mapped to the TRIADS framework as (1) inquiring about adversity (2) assessing signs of distress, or (3) identifying patient strengths and resilience. We summarized best clinical practices within each category and designed a case-based webinar and workshop series demonstrating the application of TRIADS in family planning for California family planning clinicians. A post-webinar online survey was conducted to assess confidence in applying the TRIADS framework to clinical practice.
Results:
Among 22 of 28 eligible first-year family planning fellows who completed the survey, some were comfortable inquiring about trauma (64%), responding to trauma (77%), and performing a trauma-informed pelvic exam (64%). Although all reported caring for high-risk populations, 27-41% had received minimal to no formal training in trauma-informed care and 91% were interested in additional training. Our literature review and baseline survey data support the use of a TRIADS-like framework in addressing trauma history. Among 300 family planning clinicians who attended the webinar, the 120 who completed a post-webinar survey demonstrated high confidence with trauma inquiry and response as well as a high likelihood of using the TRIADS framework in clinical practice.
Conclusions:
The TRIADS framework may be a useful tool in family planning settings that can enhance provider competence, strengthen the patient-clinician relationship, and build patient skills to improve reproductive health outcomes. Next steps include modifying the training workshop to specifically meet trainee needs, administering the training to family planning fellows, and conducting a post-training survey of family planning fellows to understand the effect of training on trainee knowledge, attitudes, and skills in trauma inquiry and response. 
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