459 research outputs found
Kir channel expression differs in distinct types of hippocampalastrocytes and is altered in epilepsy
No full textKir channel expression differs in distinct types of hippocampalastrocytes and is altered in epilepsy
No full textAssessment of the distraction regenerate using three-dimensional quantitative computer tomography
No full textThis study presents a new method for objective assessment of the distraction regenerate using three-dimensional quantitative computer tomography (3D-QCT). The distraction specimens of 16 sheep that underwent bifocal cranial distraction osteogenesis to reconstruct a critical size defect were used to evaluate this method. To analyse the validity of this method the results were compared to conventional quantitative computer tomography (QCT). Squared correlation coefficients (r(2)) according to Sackett showed a high reliability (r(2) > 70% for the total DO regenerate, DO Regions 2-4). Method comparison according to Bland-Altman (less than or equal to 6.25% of measurements out of 95% limits of agreement) showed that three-dimensional computer tomography based bone densitometry is valid for future DO research
Biological performance of biomimetic calcium phosphate coating of titanium implants in the dog mandible
No full textThe aim of the present study was to analyze the in vivo effect of biomimetic calcium phosphate coating of titanium implants on periimplant bone formation and bone-/implant contact. Five types of implants were used: 1) Ti6Al4V implants with a polished surface; 2) Ti6Al4V implants with collagen coating; 3) Ti6Al4V implants with a mineralized collagen layer; 4) Ti6Al4V implants with sequential coating of hydroxyapatite (HA) and collagen; and 5) Ti6Al4V implants with HA coating only. All implants had square cross sections with an oblique diameter of 4.6 mm and were inserted press fit into trephine burr holes of 4.6 mm in the mandibles of ten beagle dogs. The implants of five animals each were evaluated after a healing period of 1 month and 3 months, respectively, during which time sequential fluorochrome labeling of bone formation had been performed. Bone formation was evaluated by morphometric measurement of the newly formed bone around the implants and the percentage of implant bone contact. After 1 month, there was a significantly higher percentage of mean bone/implant contact in the HA-coated implants compared to those with polished surface and those with the collagen-coated surface. After 3 months, these differences were not present anymore. Bone apposition was significantly higher next to implants with sequential HA/collagen coating compared to polished surfaces and mineralized collagen layer. It is concluded that biomimetic coating of titanium implants with HA has shown the clearest trend to increase bone-implant contact in the early ingrowth period. The addition of collagen to an HA coating layer may hold some promise when used as sequential HA/collagen coating with mineralized collagen as the surface layer. (C) 2002 Wiley Periodicals, Inc
Die Geschichte des Instituts für Allgemeine und Experimentelle Pathologie sowie der Propädeutischen Klinik der Deutschen Universität in Prag
No full textDie Geschichte des Instituts für Allgemeine und Experimentelle Pathologie sowie der Propädeutischen Klinik der Deutschen Universität in Prag
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