223 research outputs found
Siblings' perspectives on their relationships with a brother or sister with autism
No full textThis study compared adjustment and quality of relationship in siblings of adolescents and young adults with Autism Spectrum Disorder (ASD; n = 27) and siblings with typical development (n = 27). Siblings completed the Network of Relationships Inventory-Behavioral Systems Version and Symptom Checklist-90-R. Only for siblings of adolescents and young adults with ASD, we conducted in-person semi-structured interviews for evaluating the sibling relationship in terms of similarity and differences, siblings' demands, and feelings. Results demonstrated that the two groups showed different emotional relationship and adjustment. A qualitative survey lead to several interesting suggestions to plan support's projects for adolescents siblings and young adults. The findings of this study emphasize the importance of carefully considering the domains included in future research on individual's psychological well-being and quality of sibling relationship for planning intervention programs siblings of adolescents and young adults with Autism Spectrum Disorder
Ritratto di Giuseppe Gradilone Filologo Critico Storico
Get PDFIl presente saggio prende in esame la figura dello studioso Giuseppe Gradilone. I tre termini ‘filologo critico storico’ caratterizzano la intensa, innovativa e originale attività e orientano chi si accinge a leggere la sua opera. Per la composizione di questo studio è stato consultato l’archivio privato del Gradilone, dove sono stati trovati scritti di critici italiani e albanesi e lettere inedite. Il lavoro è consistito nel riportare passi scelti di questi materiali, nell’utilizzare rievocazioni autobiografiche e ricordi pertinenti alla sua personalità di uomo e di studioso, nel presentare specimina delle sue opere in modo che il suo ritratto fosse completo
Cilia and Cancer: From Molecular Genetics to Therapeutic Strategies
No full text: Cilia are microtubule-based organelles that project from the cell surface with motility or sensory functions. Primary cilia work as antennae to sense and transduce extracellular signals. Cilia critically control proliferation by mediating cell-extrinsic signals and by regulating cell cycle entry. Recent studies have shown that primary cilia and their associated proteins also function in autophagy and genome stability, which are important players in oncogenesis. Abnormal functions of primary cilia may contribute to oncogenesis. Indeed, defective cilia can either promote or suppress cancers, depending on the cancer-initiating mutation, and the presence or absence of primary cilia is associated with specific cancer types. Together, these findings suggest that primary cilia play important, but distinct roles in different cancer types, opening up a completely new avenue of research to understand the biology and treatment of cancers. In this review, we discuss the roles of primary cilia in promoting or inhibiting oncogenesis based on the known or predicted functions of cilia and cilia-associated proteins in several key processes and related clinical implications
Significance of Circulating Tumor Cells in Soft Tissue Sarcoma
Get PDFCirculating tumor cells can be detected from the peripheral blood of cancer patients. Their prognostic value has been established in the last 10 years for metastatic colorectal, breast, and prostate cancer. On the contrary their presence in patients affected by sarcomas has been poorly investigated. The discovery of EpCAM mRNA expression in different sarcoma cell lines and in a small cohort of metastatic sarcoma patients supports further investigations on these rare tumors to deepen the importance of CTC isolation. Although it is not clear whether EpCAM expression might be originally present on tumor sarcoma cells or acquired during the mesenchymal-epithelial transition, the discovery of EpCAM on circulating sarcoma cells opens a new scenario in CTC detection in patients affected by a rare mesenchymal tumor
Tyrosinase Expression as a Molecular Marker for Investigating the Presence of Circulating Tumor Cells in Melanoma Patients
No full textIn 1991, Reverse Transcriptase–Polymerase Chain Reaction (RT-PCR) was introduced to assess the expression
of Tyrosinase in the peripheral blood of melanoma patients, in order to identify the presence of Circulating Melanoma
Cells. To date, hundreds of studies, some of which are reviewed here, were performed to assess the clinical value of tyrosinase
expression alone, and/or, in addition to other molecular markers. Unfortunately no consensus on the utility of tyrosinase
detection exists. In this paper, we underline the presence of too many variables that may interfere with the detection
of circulating melanoma cells: from withdrawal and RNA extraction, to Reverse Transcriptase–Polymerase Chain
Reaction and the assays used for the analysis of amplification products
Biological removal of ammonia in water treatment plants: the case of the plant in Castel S. Pietro (BO)
No full textThis paper presents the case of a water work which treats groundwater containing high quantity of ammonia, iron, manganese. In particular it discusses the choices and the reasons which led to the current water plant configuration, then it analyzes how the plant works, presents the removal efficiencies for the main pollutants and provides investment and operational costs
PEACEKEEPING E ILLECITI A DANNO DELLE POPOLAZIONI LOCALI: RESPONSABILITÀ E RIMEDI
No full textIllicit acts committed against local populations during peacekeeping missions may entail the international responsibility/tortious liability of international organisations and their member States. Since military contingents deployed during peacekeeping missions are State organs placed at the disposal of international organisations, it is very difficult to establish which entity is responsible for the wrongful acts and omissions put in place by peacekeepers. To give an answer to this question, it is necessary to understand the rules concerning attribution of conduct of State organs placed at the disposal of an international organisations. Though considerable work has been done in in this regard, the issue is still debated. Moreover, it is not easy to determine which remedies are available to individuals injured by peacekeeping missions, because of lack of practice and information. The objective of the research activity was, on one side, to get more insight into the meaning of 'effective control' (i.e. the criterion suggested by the United Nations International Law Commission within the Draft articles on responsibility of international organisations to solve the issue of attribution of conduct of peacekeepers) in order to identify its constitutive elements; on the other side, the research was aimed at analyzing existing reparation mechanisms, in order to evaluate their efficiency and their compatibility with the so called equivalent protection theory. In reference to attribution, the study allowed to elaborate a notion of 'effective control' which should be able to attribute the conduct of peacekeepers to the entity that under the specific circumstances of the case presents a factual link with them. For what regards the remedies issue, the research allowed to identify the shortcomings affecting existing mechanisms and to formulate some de lege ferenda proposals to improve their efficiency
ABCB5 in peripheral blood of a patient affected by multiple primary malignancies
No full textLa sindrome da neoplasie multiple è caratterizzata dall’insorgenza di diversi tumori in maniera sincroma in un organismo. Il caso da noi riportato ha evidenziato la presenza di sei diverse neoplasie primarie nell’arco di quattro anni. Il paziente è stato affetto da adenocarcinoma prostatico, carcinoma duttale mammario, linfoma (CD 20+), due melanomi indipendenti e un basalioma. È stata, quindi, effettuata la ricerca di marker di staminalità nel sangue periferico e nei linfonodi sentinella, dimostrando la presenza del recettore ABCB5, tipico del melanoma
Internalizing and externalizing behaviors and close relationships in siblings of adolescents with autism spectrum disorder
No full textThe literature on typically developing (TD) siblings of individuals with Autism Spectrum Disorder (ASD-TD siblings) has grown over the last few decades, providing inconsistent results. Much attention has been reserved to sibling relationships when one shows ASD symptoms. The purpose of the current study was to examine the mutual influences between ASD-TD siblings' emotional and behavioral characteristics, as evaluated by mothers, and the different dimensions of the sibling relationship through the lens of the behavioral system model Specifically, the role of ASD-TD siblings' emotional and behavioral functioning on sibling relationship was investigated. We hypothesized that the presence of internalizing and externalizing behaviors in ASD-TD siblings may be associated with less support, more negative interactions, and conflict in the sibling relationship. The sample included 59 ASD-TD siblings (35 M and 24 F; age range: 11-18 years, M = 14.20, SD = 1.52) of adolescents with ASD and their mothers. Behavioral and emotional characteristics of ASD-TD siblings showed significant associations with sibling relationship dimensions. Specifically, support was negatively and significantly related to externalizing behavior, whereas conflict was positively related to internalizing behavior. Additionally, externalizing and internalizing behaviors showed a predictive role: Externalizing behavior emerged as a significant negative predictor of support and internalizing behavior emerged as a significant positive predictor of negative interaction
Tyrosinase Expression as a Molecular Marker for Investigating the Presence of Circulating Tumor Cells in Melanoma Patients
No full textIn 1991, Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) was introduced to assess the expression of Tyrosinase in the peripheral blood of melanoma patients, in order to identify the presence of Circulating Melanoma Cells. To date, hundreds of studies, some of which are reviewed here, were performed to assess the clinical value of tyrosinase expression alone, and/or, in addition to other molecular markers. Unfortunately no consensus on the utility of tyrosinase detection exists. In this paper, we underline the presence of too many variables that may interfere with the detection of circulating melanoma cells: from withdrawal and RNA extraction, to Reverse Transcriptase-Polymerase Chain Reaction and the assays used for the analysis of amplification products
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