5,234 research outputs found
Response from Drs. Formica/Zaniboni to Dr. Milano
No full textWe would like to thank Dr. Milano et al. for the point
they made on the possible role of drug-induced immune
response occurring during treatment with either anti-VEGF
or anti-EGFR agent
La città nel Settecento: Saperi e forme di rappresentazione
No full textVolume di saggi sulla città nel XVIII secol
A checklist of the ants of Wyoming (Hymenoptera: Formicidae)
No full textThe history of myrmrecology in Wyoming began when Fore1 described a new species, obscuripes in the genus Formica from Green River in 1886, four years before Wyoming Territory became a state. There was a long hiatus until 1932 when Cole cited ten records for Pogonomyrmex occidentalis. Since then a dozen authors have published one to many records each. During the summers of 1957, 1958, 1961, 1963, 1964,1965 and 1966, while we were still at the University of North Dakota (Grand Forks), we made a dozen field trips into Wyoming to observe and collect ants in 12 of the 23 counties and in Yellowstone National Park. These expeditions yielded a total of 168 records for 45 species (a record is a species in a locality)
Misteri svelati. Roma e il Vaticano nella narrativa finzionale del XIX secolo
No full textRoma ottocentesca ha fornito un ricco repertorio di protagonisti, figure e attori pe rie romanzo storico, che, nel corso del XIX secolo vide la sua affermazione a livello europeo specialmente nel genere della cronaca nera e dei cosiddetti fait-divers. Si tratta di una ricognizione della narrativa di ambientazione romana ricondotta a diversi contesti quello del cattolicesimo intransigente e quello anticlericale dei Misteri su modello francese dei Mystères
“The Mirror of God”. Gregorio XIII and the Reform of the Calendar
No full textIt was on the first of January 45 BC when calendar reform instigated by Julius Caesar came into force. From then until fifteen centuries later on February 24, 1582, when Pope Gregorio XIII issued the Inter gravissimas pastoralis officii nostri curas by means of which, thanks to a drastic subtraction of ten days for the October of that year, a system of calculation of the days and months, which was more accurate than the previous system, was developed. This was a decision which was both courageous and definitive and a decision which is now widely accepted in most countries in the world, so much so that even where the Gregorian calendar has not yet been fully implemented, there is still hope about achieving a convergence on consensus for the date regarding the celebration of Easter. Not surprisingly, on May 6, 2014, the Patriarch of the Coptic Orthodox Church, Tawadros II, encouraged Pope Francis to move precisely in this direction.
History and Geography together thus seem to join forces in highlighting the importance of the reform of The Gregorian calendar as a watershed and central reality in the West and, by extension, throughout the whole world. And, it was in this great attempt at guiding civil and religious life in Europe – towards what was eloquently called the “Mirror of God” – that Villa Mondragone served as the magnificent and majestic backdrop
Formica fossaceps Buren and Formica obscuriventris clivia Creighton as Slaves of Formica rubicunda Emery
No full textObservations on mixed colonies have shown that Formica fossaceps and Formica obscuriventris clivia both live as slaves for Formica rubicunda together with Formica cinerea montana and Formica fusca. Formica obscuriventris clivia may start its colonies as a temporary social parasite of fusca
The 'death pace' in the CO.17 trial
No full textIn an era where the cost of care in oncology is rising, suggestions of new frameworks that may help in orienting biomarker discovery are highly desirable. We propose a different perspective for looking at survival data, which we call 'death pace' analysis, which focuses on the variation of the gap between survival curves over time and that may make it easier to identify subpopulations with distinct predictive molecular features. The recently published data on EJC on the impact of the primary colonic site in the CO.17 trial seem to be particularly suitable for the death pace analysis
Linkage of biopsy, cancer, and population records aimed at the estimation of family risks in neoplasia: a pilot study
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LINKAGE OF BIOPSY, CANCER, AND POPULATION RECORDS AIMED AT THE ESTIMATION OF FAMILY RISKS IN NEOPLASIA - A PILOT-STUDY
Author(s): BARRAI, I (BARRAI, I); NENCI, I (NENCI, I); GUIDI, E (GUIDI, E); DELLACQUA, G (DELLACQUA, G); FORMICA, G (FORMICA, G); BARBUJANI, G (BARBUJANI, G); MARZOLA, A (MARZOLA, A); MARANI, G (MARANI, G); BARALE, R (BARALE, R); BERETTA, M (BERETTA, M)
Source: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH Volume: 45 Issue: 2 Pages: 107-111 DOI: 10.1136/jech.45.2.107 Published: JUN 1991
Times Cited: 1 (from Web of Science)
Cited References: 15 [ view related records ] Citation Map
Abstract: Study objective-The aim was to link individual demographic and medical records into sibships to obtain the sibling distribution of biopsies and cancers, and thereby calculate heritability and recurrence risks in families, thus aiding early diagnosis and prevention of cancers.
Design-The 157 823 individual records of the inhabitants of the town of Ferrara in Italy were automatically linked into 106 821 sibships. A 10% sample (10 842 sibships) was then extracted from the distribution of sibships and tabulated, for linkage to medical records.
Patients-The biopsy records at the Institute of Pathological Anatomy of the University of Ferrara were manually linked to cancer records and then to sibships. It was possible to construct the distribution of 2062 biopsies and of 829 cancers in sibships.
Results-From the distribution of biopsies and tumours in sibships, it was possible to estimate the incidence of tumours in the population (0.052) and in siblings of affected (0.083), and to apply to such distributions current methods for the estimate of heritability (h2 = 0.246) and of recurrence risks of tumours in sibships, age independent.
Conclusions-The study shows that the procedure resulting in the estimation of incidences and recurrence risks for tumours could be completely automated, and extended to whole populations and homogeneous subgroups in post industrial cultures
The Best. First. Anti-EGFR before anti-VEGF, in the first-line treatment of RAS wild-type metastatic colorectal cancer: from bench to bedside
No full textSince 2013, informative trials exploring the optimal use of available biologic agents in the first-line setting of metastatic colorectal cancer (mCRC) have been presented. These trials have opened a stimulating debate on the biological effect that first-line therapies may have on subsequent lines of treatment even long after the first-line progression.We reviewed available preclinical and clinical data on the effect of different sequences of the biological drugs approved for use in mCRC patients. The importance of molecular selection of patients based on RAS mutational status and toxicity and quality-of-life issues were also analyzed.Convincing evidence exists on the optimal therapeutic effect obtained by using anti-EGFR agents in first-line treatment before anti-VEGF agents. On the contrary, up-front anti-VEGF agents' use seems to determine biological changes that increase the risk of acquired resistance to subsequent EGFR inhibitors. This hypothesis is confirmed by the scarce evidence of EGFR inhibitor activity in second-line treatment. Such a therapeutic optimum is subject to a fine molecular selection based on RAS mutational status.There is accumulating evidence suggesting that, after precise and well-established molecular selection, anti-EGFR agents deliver their maximum efficacy in mCRC patients when given early in the treatment strategy. Their toxicity profile seems manageable under the supervision of experienced physicians. Large randomized trials prospectively confirming the impact of different sequencing strategies are eagerly awaited
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