30 research outputs found
Oxygen consumption and hemodynamics in Type 1 diabetes patients during stress testing
No full textIn 128 patients with Type 1 diabetes mellitus (DM-1) and 38 healthy volunteers, hemodynamic component of gas-transporting system was assessed in bicycle stress test, with permanent monitoring of О2 consumption, heart rate (HR), systolic and diastolic blood pressure (SBP, DBP). O2 pulse was calculated, and anaerobic threshold was determined. DM-1 patients were divided into three groups: Group 1 - without clinically manifested microangiopathy; Groups 2 and 3 -with initial and progressed manifestation of late diabetic syndrome. In all three groups, comparing to controls, mean peak О2 consumption and anaerobic threshold were significantly decreased. HR at peak stress was significantly lower inpatients with late diabetic complications than in controls, and О2 pulse was reduced in all three groups. During stress testing, Group 1 demonstrated significant SBP increase, Groups 2 and 3 - significant DBP increase, comparing to respective control levels. In DM-1 patients, disturbances of gas-transporting system hemodynamic component, registered during stress testing, develop before clinical microangiopathy manifestation. The latter progresses substantially during late diabetic syndrome evolution
Otcepljenje putem oružane sile: komparativna studija Čečenije i Kosova
No full textTekst se bavi manjkavostima strukturalističkog objašnjenja upotrebe sile
prilikom pokušaja secesije. Uporednom analizom slučajeva secesije Kosova i
Čečenije pokazuje se da pored toga što postoje uporedivi strukturalni uslovi
za primenu oružane sile, secesionistički pokreti, u ova dva slučaja, razlikuju
se značajno u stavu prema upotrebi oružane sile u periodu pre pokušaja
otcepljenja. Autor smatra da pored strukturalnih faktora i ljudski činioci
imaju važnu ulogu pri opredeljivanju za taktiku oružane pobune. Ova teza
se potkrepljuje ulogom secesionističkih vođa Džohara Dudajeva u Čečeniji
i Ibrahima Rugove na Kosovu. Različite biografije, obrazovanje i lične
karakteristike lidera su doprinele da se ovi secesionistički pokreti opredele za
različite političke taktike i preferencije u pogledu upotrebe oružane sile.The paper deals with deficiencies of structural explanation of the use of force
during attempts at secession. Comparative analysis of the cases of Kosovo and
Chechnya has demonstrated that these two secessionist movements differed
in their stances toward the use of armed forces prior the secessionist attempts
even though comparable structural conditions for the use of armed forces
existed in these cases. Alongside of structural factors, the author considers
human factor as performing an important role in selection of tactics of armed
rebellion. This thesis has been corroborated by the roles of the secessionist
leaders Dzhokhar Dudaev in Chechnya and Ibrahim Rugova in Kosovo.
Different biographies, education and personal characteristics of the leaders
have contributed to diverse political tactics and preferences in terms of the
use of armed forces
Mathematical simulation of pulsed electromagnetic soundings with a spatially distributed system of deviated wells
No full textChitosan-modified ceftazidime loaded polyhydroxyalkanoates microparticles: preparation, characterization and antibacterial evaluation in vitro
No full textBackground and purpose: The use of drug delivery systems to enhance the efficacy of existing antimicrobial drugs is one of the promising approaches to combat bacterial resistance. The simultaneous presence of a polycationic biopolymer (chitosan) and an antibacterial drug (ceftazidime) in polyhydroxyalkanoates microparticles is more effective since it allows such carriers to have a more pronounced therapeutic effect. In this study, chitosan-modified ceftazidime-loaded poly(3-hydroxybutyrate-3-hydroxyvalerate-3-hydroxy-hexanoate) (P(3HB-3HV-3HHх)) microparticles were prepared and investigated as a drug delivery system. Experimental approach: The obtained microparticles were characterized in terms of their particle size, polydispersity index (PDI), zeta potential, encapsulation efficiency, drug release studies in vitro, cytotoxicity and antibacterial properties in cell cultures. Key results: The microparticles had spherical shapes with diameters from 0.6 to 1.6 µm. The constructed chitosan-modified ceftazidime-loaded microparticles are a depot form of drug, the release of which in vitro is realized for a long time, without burst releases, corresponds to Korsmeyer-Peppas and Higuchi models. In vitro cell viability and proliferation studies on designed microparticles investigated using HaCaT (human keratinocyte skin cell lines) showed good cell proliferation. The hemolytic activity of chitosan-modified P(3HB- 3HV-3HHх) microparticles evaluated by hemolysis assay demonstrated good blood compatibility. Chitosan-modified microparticles enhanced the antibacterial activity of ceftazidime, being effective against E. coli and St. aureus. Conclusion: Thus, the obtained drug delivery systems based on PHAs and chitosan in the form of microparticles can be promising means in treating infectious skin diseases for topical use
Resorbable Nanomatrices from Microbial Polyhydroxyalkanoates: Design Strategy and Characterization
No full textFrom a series of biodegradable natural polymers of polyhydroxyalkanoates (PHAs)—poly-3-hydroxybutyrate (P(3HB) and copolymers containing, in addition to 3HB monomers, monomers of 3-hydroxyvalerate (3HV), 3-hydroxyhexanoate (3HHx), and 4-hydroxybutyrate (4HB), with different ratios of monomers poured—solvent casting films and nanomembranes with oriented and non-oriented ultrathin fibers were obtained by electrostatic molding. With the use of SEM, AFM, and measurement of contact angles and energy characteristics, the surface properties and mechanical and biological properties of the polymer products were studied depending on the method of production and the composition of PHAs. It has been shown in cultures of mouse fibroblasts of the NIH 3T3 line and diploid human embryonic cells of the M22 line that elastic films and nanomembranes composed of P(3HB-co-4HB) copolymers have high biocompatibility and provide adhesion, proliferation and preservation of the high physiological activity of cells for up to 7 days. Polymer films, namely oriented and non-oriented nanomembranes coated with type 1 collagen, are positively evaluated as experimental wound dressings in experiments on laboratory animals with model and surgical skin lesions. The results of planimetric measurements of the dynamics of wound healing and analysis of histological sections showed the regeneration of model skin defects in groups of animals using experimental wound dressings from P(3HB-co-4HB) of all types, but most actively when using non-oriented nanomembranes obtained by electrospinning. The study highlights the importance of nonwoven nanomembranes obtained by electrospinning from degradable low-crystalline copolymers P(3HB-co-4HB) in the effectiveness of the skin wound healing process
Moral and Psychological State of the Student’s Personality During End-of-Term Exams
No full textThe article presents key aspects of the moral and psychological state of the student's personality, as well as examines the characteristics of age and levels of anxiety as factors that affect the moral and psychological state of the students. Throughout the study, it is concluded that these categories, in addition to adaptation to new conditions, are determining factors for the moral and psychological affection of the student's personality.El artículo presenta aspectos clave del estado moral y psicológico de la personalidad del estudiante, así como también, examina las características de edad, niveles de ansiedad como factores que afectan el estado moral y psicológico de los estudiantes. A lo largo del estudio, se concluye que estas categorías, además de la adaptación a las nuevas condiciones, son determinantes para la afección moral y psicológica de la personalidad del alumno
Features of Professional and Psychological Training of an Accountant-Analyst for Making Management Decisions in an Economic Crisis
No full textA Comprehensive Solution of the Problems of Ensuring the Strength of Gas Turbine Engine Compressor at the Design Stage
No full textVyiavlenie zavisimosti valiutnogo kursa rublia i tseny na neft' pri pomoshchi korreliatsionno-regressionnogo analiza
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