694 research outputs found
Examining different perspectives on fatherhood: a socio-cultural approach
No full textAbstractMain purpose of the present investigation is to explore cultural perspectives on different aspects of fatherhood. In this study, we analyze perspectives of different cultures on fatherhood by focusing mainly on mythologies, and religious perspectives. Findings suggest that provision, protection, formation (formation of the child's character), and endowment (giving legal status to a child) functions seem to be viewed as primary functions of fatherhood across cultures. © 2011 Published by Elsevier Ltd
The perceptions of early childhood children and parents towards children's participation rights: ‘Yes, I and I Disagree!’
No full textTARAMAWOSWOS:000715077800001TARAMASCOPUSIn this study, the primary purpose is to analyse early
childhood children's and their parents’ perceptions towards
‘children's participation rights. Accordingly, this
study applies a phenomenology model pattern which is
one of the qualitative research approaches. Fifteen children
between 48 and 72 months and one of the parents
(mother or father) participated in this study. The semi-structured
interview technique was selected to collect
data. Content analysis was applied to analyse the data,
and specific codes and themes were created. The findings
obtained from data analysis were discussed with
the participation ladder proposed by Roger Hart
The effect of creative drama activities in early childhood on the executive functions of children
No full textTARAMAWOSWOS:000596616100001TARAMASCOPUSIn this study, it is aimed to reveal the effect of creative drama activities implemented in early childhood on the executive functions of children who are between 60 and 72 months old. The study is designed as quasi experimental study with pretest and posttest control group. In the class determined as the experimental group, 18 drama sessions, which are planned according to the learning outcomes improving executive functions, were implemented. In the study, to evaluate the executive functions of the children The Map Task, Camel- Dwarf Game and Tower of London Test were used as data collection tools. A meaningful difference was observed in the executive functions of forward memory and the backward memory, inhibition, problem solving and cognitive flexibility of the children in the experimental group that the creative drama activities were implemented
Herşey Dahil (All-Inclusive) Sisteminin Ülke Turizmine ve İşletme Karlılığına Katkısı Konusunda Görüşler (Marmaris ve İçmeler Örneği)
No full textTürkiye, özellikle son yıllarda, sahip olduğu doğal güzellikleri ve tarihi zenginlikleriyle kitle turizmi yapan Avrupalı seyahat acentelerinin büyük bir pazarı haline gelmiştir. Ancak bu pazarda turistik ürünlerin paket turlar halinde ve herşey dahil (all-inclusive) uygulaması adı altında tek bir fiyatla sunulması ülkemiz turizmini olumsuz etkilemektedir. Bu araştırma, Marmaris ve çevresinde herşey dahil sistem ile çalışan 40 otel yöneticisine anket uygulanarak yapılmıştır. Araştırmanın amacı, "herşey dahil" sisteminde karşılaşılan sorunları belirlemek ve bu sistemin ülke turizmi açısından nasıl daha yararlı hale getirilebileceğini saptamaktır. Araştırmanın sonucunda "herşey dahil" sisteminin karlılığının işletmelerin büyüklüğüne göre farklılık gösterdiği ancak, ülke turizmine katkısının olumlu olmadığı tespit edilmiştir.Turkey, with its natural beauties and historical wealthinesses has especially become a big market of European travel agencies which arrange mass tourism organizations in recent years. But it has influenced country's tourism negatively that the touristic products are presented with package tours and in only certain price withthe all-inclusive system. This study has been conducted by using survey with 40 hotel managers working in all-inclusive system in Marmaris and its vicinity. The objective of this research is to determine the issues met in all-inclusive system and to establish how this system can be made more useful in terms of the country tourism. As the conclusion of the research, it has indicated that the profit of the all-inclusive system may differ according to the size of the enterprise but, its profit is not positive to the country tourism
Outcomes of pirtobrutinib for relapsed/refractory mantle cell lymphoma in compassionate use program in Europe.
No full textBACKGROUND
Mantle cell lymphoma (MCL) is a type of B-cell lymphoma that is currently incurable. Pirtobrutinib shows promising response rates in heavily pretreated MCL patients according to the approval study, but the real-world data are scarce.
METHODS
In this study, we retrospectively analyzed the efficacy and safety profile of pirtobrutinib in 10 relapsed/refractory MCL patients from compassionate use program (CUP).
RESULTS
On average, the patients underwent three lines of systemic therapy prior to pirtobrutinib and were predominantly BTKi exposed (9/10). The best overall response rate (BORR) was 67%. In a median follow-up of 8.6 months, the mean duration of response (DOR), progression-free survival (PFS), and overall survival (OS) were not reached. No new safety signals were documented.
CONCLUSIONS
In summary, pirtobrutinib represented a safe and effective treatment option in a small real-world population
Predicting adverse events for risk stratification of chemotherapy based stem cell mobilization in multiple myeloma
No full textAutologous stem-cell transplantation is a fundamental therapy for multiple myeloma. Although inpatient chemo-based stem-cell mobilization (SCM) is standard care in Germany, outpatient approaches could ease healthcare constraints. We analyzed 109 myeloma patients undergoing SCM and collection at the University Medical Center Göttingen for safety. We then trained machine learning models to predict adverse events (AEs) requiring hospitalization and to forecast AE onset timing for optimized ward management. In our cohort, 97% achieved successful collection, but 69% experienced severe AEs necessitating hospitalization. Simulations suggest a risk-stratified outpatient protocol could cut bed usage by at least one third without compromising safety. Classification models accurately predicted some AE types (e.g., elevated creatinine, ROC-AUC 1.0), though neutropenic fever remained challenging (ROC-AUC 0.67). Regression models forecast AE onset with a mean error of just over one day. These results outline a data-driven roadmap for safely adopting outpatient SCM and optimizing resource allocation in clinical practice
Hypernatriämie und Polyurie bei einer Patientin mit Erstdiagnose einer sekundären akuten myeloischen Leukämie
No full textA 66-year-old female patient with the initial diagnosis of acute myeloid leukemia is reported. Paraneoplastic syndrome manifested as hypernatremia due to central diabetes insipidus (CDI), which could be controlled with the administration of desmopressin. After initiation of the induction therapy, the required desmopressin administration could be reduced and terminated. In the further course, the early increasing polyuria and hypernatremia indicated the primary refractory acute myeloid leukemia
A semi-analytical methodology for development of woven geotextile filter selection criteria
No full textABSTRACT: Geotextiles have been commonly used in geotechnical and environmental engineering projects to prevent erosion of soils in contact with the filter without impeding the flow of seeping water through the soil. Several empirical criteria incorporating varying factors of safety have been proposed for selection of geotextile filters. A probabilistic numerical filter model, named RETAIN, using image-based geotextile pore structure was developed for woven geotextile filters and is presented in this paper. The paper also summarizes a new methodology to propose filter selection criteria using the results of RETAIN. The proposed criteria based on this methodology and the existing empirical criteria from the literature were evaluated against the actual performance observed in the laboratory filtration tests on a silty sand specimen and a wide range of woven geotextiles. The results indicated that RETAIN can model the filtration behavior of silty sands and woven geotextiles, and the model output can be used to develop new geotextile selection criteria. The method is currently applicable to one type of soil; however, the method is rational, and the applicability of the methodology to other soils with a range of particle size distributions can be checked after conducting laboratory filtration tests on these soils
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