1,234 research outputs found
Diagnosis and management of catamenial seizures: A review
No full textCatamenial epilepsy is defined as a pattern of seizures that changes in severity during particular phases of the menstrual cycle, wherein estrogens are proconvulsant, increasing the neuronal excitability; and progesterone is anticonvulsant, enhancing GABA-mediated inhibition. Thus, changes in serum estradiol/progesterone ratio throughout a normal reproductive cycle bring about an increased or decreased risk of seizure occurrence. To date, there are no specific drug treatments for catamenial epilepsy however, non-hormonal and hormonal therapies have been proposed. The aim of this review is to report preclinical and clinical evidences about the relationship between female reproductive steroids and epileptic seizures, and to describe treatment approaches for catamenial epilepsy. © 2012 Verrotti et al. publisher and licensee Dove Medical Press Ltd
Diagnosis and management of catamenial seizures: a review
No full textAlberto Verrotti,1 Claudia D’Egidio,1 Sergio Agostinelli,1 Carla Verrotti,2 Piero Pavone31Department of Paediatrics, University of Chieti, 2Department of Obstetrics and Gynecology, University of Parma, 3Unit of Paediatrics, University Hospital “Vittorio Emanuele”, Catania, ItalyAbstract: Catamenial epilepsy is defined as a pattern of seizures that changes in severity during particular phases of the menstrual cycle, wherein estrogens are proconvulsant, increasing the neuronal excitability; and progesterone is anticonvulsant, enhancing GABA-mediated inhibition. Thus, changes in serum estradiol/progesterone ratio throughout a normal reproductive cycle bring about an increased or decreased risk of seizure occurrence. To date, there are no specific drug treatments for catamenial epilepsy however, non-hormonal and hormonal therapies have been proposed. The aim of this review is to report preclinical and clinical evidences about the relationship between female reproductive steroids and epileptic seizures, and to describe treatment approaches for catamenial epilepsy.Keywords: catamenial epilepsy, estrogens, progesterone, neurosteroid
Seizures in fetal alcohol spectrum disorders: Evaluation of clinical, electroencephalographic, and neuroradiologic features in a pediatric case series
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Epilepsia
Volume 55, Issue 6, June 2014, Pages e60-e66
Seizures in fetal alcohol spectrum disorders: Evaluation of clinical, electroencephalographic, and neuroradiologic features in a pediatric case series (Article)
Nicita, F.a , Verrotti, A.b, Pruna, D.c, Striano, P.d, Capovilla, G.e, Savasta, S.f, Spartà, M.V.f, Parisi, P.g, Parlapiano, G.h, Tarani, L.h, Spalice, A.a
a Child Neurology Division, Department of Pediatrics, Sapienza University of Roma, Viale Regina Elena, Rome-324-00161, Italy
b Department of Pediatrics, University of Perugia, Perugia, Italy
c Division of Child Neurology and Psychiatry, Azienda University Hospital of Cagliari, Cagliari, Italy
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Abstract
Seizures are observed with a frequency of 3-21% in children with fetal alcohol spectrum disorders (FASD). However, clinical, neuroradiologic, and electroencephalography (EEG) features are poorly described. In this study, 13 patients with FASD and epilepsy or seizures were identified retrospectively from the databases of seven Italian pediatric neurology divisions. Eleven children were affected by epilepsy, and two had at least one documented seizure. Both generalized and focal seizures were observed. EEG showed diffuse or focal epileptic activity; two children developed electric status epilepticus during sleep (ESES). Structural brain anomalies, including polymicrogyria, nodular heterotopia, atrophy, and Arnold-Chiari type 1 malformation, were discovered in almost 50% of patients. Control of seizures was not difficult to obtain in 11 cases; one patient showed pharmacoresistant epilepsy. EEG and clinical follow-up are recommended in children with FASD and epilepsy, since severe conditions requiring aggressive treatment, such as in ESES, may develop. Neuroradiological evaluation is warranted because several types of brain anomalies could be associated with maternal alcohol consumption during pregnancy
Intrapancreatic rupture of a splenic artery aneurysm during pregnancy – a rare case report with fetal and maternal survival
No full textJ Matern Fetal Neonatal Med. 2009 Apr;22(4):362-4.
Intrapancreatic rupture of a splenic artery aneurysm during pregnancy - a rare case report with fetal and maternal survival.
Patrelli TS, Anfuso S, Verrotti C, Fadda GM, Gramellini D, Nardelli GB.
SourceDepartment of Obstetrics, Gynecology and Neonatology, OB/GYN Unit, Parma General Hospital, University of Parma, Via Gramsci, Parma 14 43100, Italy. [email protected]
Abstract
Rupture of a splenic artery aneurysm (SAA) during pregnancy is a rare and severe condition. A 35-year-old woman at 34 weeks' gestation came to our observation for acute abdominal pain. After being diagnosed with intra-pancreatic SAA rupture, she was delivered of a live fetus by cesarean section. This is a rare case with both fetal and maternal survival
Infantile convulsions in association with mild gastroenteritis: an emerging clinical condition
No full textA cup full of functions
No full textData from different laboratories have recently indicated that Cup is a multi-functional protein acting both during Drosophila ovary development and early embryogenesis. Cup directly and/or indirectly affects the activity of different mRNAs and proteins to achieve a broad range of biological functions: (1) Cup interacts with Nanos to promote maintenance and survival of the female germ-line stem cells; (2) it binds eIF4E and 3'-UTR-bound factors to repress translation of oskar and nanos mRNAs; (3) it interacts genetically with eIF4E to control translation initiation during ovary development and growth; (4) it may play a role in the control of the phosphorylation status of eIF4E within the developing ovary; finally, (5) it possesses nucleo-cytoplasmic shuttling properties thus pointing to a still uncharacterized function in the cell nucleus. A multi-disciplinary approach, ranging from genetics to proteomics, will be required to shed light on the diverse molecular mechanisms involving Cup and the growing family of its specific interactors
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