698 research outputs found
What Makes Exploitation Wrongful?
No full textAs part of a book symposium on Nicholas Vrousalis' Exploitation as Domination: What Makes Capitalism Unjust (2023), Lucas Stanczyk argues that his reciprocity account of the central wrong-making feature of domination is superior to Vrousalis' domination account.
"Eros in Despair”. Jan Matejko’s „Stanczyk on Queen Bona’s Party”
No full textThe Author discusses very popular interpretations of historical picture by Jan Matejko titled Eros in Despair. Jan Matejko’s Stanczyk on Queen Bona’s Party. This is one the most known historical picture in Poland associated with extremely reach symbolic meaning. Słoczyński argues that major part of existing interpretations are rather a result of sublimation of Polish history as well as anticipation of the symbolic character of later Matejko’s masterpieces than the opinion based on a correct analysis of the discussed picture
Towards an Urban Repair and Eco-generation Paradigm A case study of Taipei’s eco-city strategy
No full textUntil recently, developers of Asian metropolitan cities have largely ignored the interconnection between nature and cities. During the early stages of urbanization in Taipei this lack of planning caused many of the current challenges faced by the city. As the movement to build more environmentally sustainable cities gains momentum as we head into the 21st century; so should the desire to upgrade existing cities to these new development aspirations. Sadly however, most of the attention primarily focuses on future cities. This thesis, on the other hand, focuses on the eco-regeneration of older cities, namely, Taipei. The strategy to regenerate the city using eco-puncture is due to the fact that repairing key locations will have the most positive impact. To achieve this endeavor the goals of this thesis are twofold; firstly to investigate Taipei ecosystem to gain a comprehensive understanding of its current and future developmental challenges. Lastly to form an eco-regeneration plan using eco-puncture methods, as acupuncture is the preferred method used in Chinese culture in the process of repairing
Prolonged recombinant pregnancy hormone use in BRCA1 and BRCA2 mutation carriers
No full textBackground
An early first full-time pregnancy substantially reduces the risk of developing breast cancer later in life. Extensive studies indicate that this protective effect is mediated by the pregnancy hormone human chorionic gonadotrophin (hCG).
Methods
In this proof-of-concept study 33 women with a BRCA mutation received recombinant-hCG (r-hCG). A 4-mm breast biopsy was obtained before (T1) and after 12 weeks of r-hCG injections (T2), as well as 6 months later (T3). The tissue was examined using RNA-sequencing methodology to determine if the 'high-risk' transcriptomic signature was converted to a 'low-risk' signature as in an early first full-time pregnancy. A stringent clinical safety monitoring was performed.
Results
The r-hCG administration was well tolerated in all participants. No clinically relevant changes were observed. In 25 women, the RNA quality was good for RNA sequencing in all three breast tissue biopsies. In response to the r-hCG, we observed 1907 differentially expressed genes (DEGs) (1032 up, 875 down) at T2 vs. T1 and 1065 DEGs (897 up, 168 down) at T3 vs. T1 in the group of women (n = 11) not using any hormonal contraceptives during the study. There was no response at T2 vs. T1 and a small number of DEGs, 260 (214 up, 46 down) at T3 vs. T1 in the group of 14 women using contraceptives.
Conclusions
In summary, r-hCG has a remarkable effect on the gene expression profile of breast tissues from BRCA1/2 carriers who did not use any contraception. This opens an opportunity for a novel preventive strategy to reduce the incidence of breast cancer
Julius Tervay Collection
No full textPhotograph of Ernest Stanczyk wearing a U.S. Army uniform and standing on a sidewalk in front of a concrete military government building
Saurian Brandy Digest Presents: Second Beginnings
No full textIssue: June/July 1978Saurian Brandy Digest Issue 1
Ernest Stanczyk Collection
No full textPhotograph of a group of people being loaded into the bed of a truck in order to be transported to Stuttgart, Germany, from a concentration camp. Several people are can also be seen on the sidewalk to the right
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