1,725,128 research outputs found
Interaction of ORG 9426 and some of the clinically used intravenous anaesthetic agents in the cat
No full textThe interaction of ORG 9426, a new non-depolarizing neuromuscular blocking agent, with intravenous anaesthetic drugs (fentanyl, thiopental, midazolam, droperidol and etomidate) has been investigated in cats. During an infusion of one of the above anaesthetics, the ED95 dose was determined by titration, and thereafter muscle relaxation was maintained with four subsequent doses of ORG 9426. Neither the potency nor the duration of action of the first dose nor that of the maintenance doses of ORG 9426 differed from those observed in a control group of cats anaesthetized with intraperitoneally administered pentobarbital. The recovery rates were similar in all groups. The authors conclude that, under the conditions of this study, commonly used intravenous anaesthetic drugs are not likely to influence the neuromuscular blocking potency and time course of action of ORG 9426 to any appreciable degree
The Neuromuscular Blocking Effects and Pharmacokinetics of ORG 9426 and ORG 9616 in the Cat
No full textThe neuromuscular blocking effects and pharmacokinetics of ORG 9426, 1.5 mg/kg and ORG 9616, 1.2 mg/kg iv, two new nondepolarizing neuromuscular blocking drugs, were studied in 28 cats (i.e., 14 cats with each drug) with and without renal pedicle ligation. A gas chromatographic assay was used to determine the concentrations of ORG 9426 and ORG 9616 and its desacetyl metabolites in plasma, urine, bile, and liver. The duration of neuromuscular blockade of both drugs was not altered by ligation of renal pedicles. Plasma clearance of ORG 9426 was slower in cats with ligated renal pedicles (P less than 0.01). With ORG 9616, mean elimination half-life was slower and mean residence time longer in cats with renal pedicle ligation. Otherwise, there was no significant differences with any pharmacokinetic variables in cats with and without renal pedicle ligation. Only 8.7 +/- 5.7% (SD) and 6.0 +/- 2.8% of an injected dose of ORG 9426 and ORG 9616 was excreted into the urine, respectively. Conversely, 54.4 +/- 9.2% and 52.4 +/- 9.2% of an injected dose of ORG 9426 and 35.7 +/- 12.2% and 46.8 +/- 9.7% of ORG 9616 were excreted into the bile in cats without and with renal pedicle ligation, respectively. Finally, 21.3 +/- 6.5% and 33.5 +/- 15.6% of ORG 9426 and 14.0 +/- 3.2% and 18.1 +/- 5.6% of ORG 9616 were in the liver 6 h after injection in cats without and with renal pedicle ligation respectively. The authors were able to account for the biodisposition of 84.4% and 85.9% of an injected dose of ORG 9426 in cats without and with renal pedicle ligation respectively
The Neuromuscular Blocking Effects and Pharmacokinetics of ORG 9426 and ORG 9616 in the Cat
No full textThe neuromuscular blocking effects and pharmacokinetics of ORG 9426, 1.5 mg/kg and ORG 9616, 1.2 mg/kg iv, two new nondepolarizing neuromuscular blocking drugs, were studied in 28 cats (i.e., 14 cats with each drug) with and without renal pedicle ligation. A gas chromatographic assay was used to determine the concentrations of ORG 9426 and ORG 9616 and its desacetyl metabolites in plasma, urine, bile, and liver. The duration of neuromuscular blockade of both drugs was not altered by ligation of renal pedicles. Plasma clearance of ORG 9426 was slower in cats with ligated renal pedicles (P less than 0.01). With ORG 9616, mean elimination half-life was slower and mean residence time longer in cats with renal pedicle ligation. Otherwise, there was no significant differences with any pharmacokinetic variables in cats with and without renal pedicle ligation. Only 8.7 +/- 5.7% (SD) and 6.0 +/- 2.8% of an injected dose of ORG 9426 and ORG 9616 was excreted into the urine, respectively. Conversely, 54.4 +/- 9.2% and 52.4 +/- 9.2% of an injected dose of ORG 9426 and 35.7 +/- 12.2% and 46.8 +/- 9.7% of ORG 9616 were excreted into the bile in cats without and with renal pedicle ligation, respectively. Finally, 21.3 +/- 6.5% and 33.5 +/- 15.6% of ORG 9426 and 14.0 +/- 3.2% and 18.1 +/- 5.6% of ORG 9616 were in the liver 6 h after injection in cats without and with renal pedicle ligation respectively. The authors were able to account for the biodisposition of 84.4% and 85.9% of an injected dose of ORG 9426 in cats without and with renal pedicle ligation respectively
Linked collectors and determiners for: Four new Amynthas and Metaphire earthworm species from nine provinces in southern China.
No full textNatural history specimen data linked to collectors and determiners held within, "Four new Amynthas and Metaphire earthworm species from nine provinces in southern China". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/8892b00f-9426-4398-afd2-db9d8412e922">https://bionomia.net/dataset/8892b00f-9426-4398-afd2-db9d8412e922</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/8892b00f-9426-4398-afd2-db9d8412e922">https://gbif.org/dataset/8892b00f-9426-4398-afd2-db9d8412e922</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Four new Amynthas and Metaphire earthworm species from nine provinces in southern China.
No full textNatural history specimen data linked to collectors and determiners held within, "Four new Amynthas and Metaphire earthworm species from nine provinces in southern China". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/8892b00f-9426-4398-afd2-db9d8412e922">https://bionomia.net/dataset/8892b00f-9426-4398-afd2-db9d8412e922</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/8892b00f-9426-4398-afd2-db9d8412e922">https://gbif.org/dataset/8892b00f-9426-4398-afd2-db9d8412e922</a>. Formatted as a Frictionless Data package
The pharmacodynamics and pharmacokinetics of Org 9426, a new non-depolarizing neuromuscular blocking agent, in patients anaesthetized with nitrous oxide, halothane and fentanyl
No full textThe pharmacodynamics and pharmacokinetics of a new non-depolarizing neuromuscular blocking agent, Org 9426, were investigated. Ten patients undergoing elective head and neck surgery and anaesthetized with nitrous oxide, halothane and fentanyl, received a bolus dose of Org 9426 (1 mg.kg-1, 3 x ED90). The isometric contractions of the adductor pollicis muscle following ulnar nerve stimulation (0.1 Hz and intermittent TOF) were measured. Blood and urine were sampled over 8 and 24 hr, respectively. Concentrations of Org 9426 and its possible metabolites in plasma and urine were determined using HPLC. Pharmacokinetic variables were calculated by iterative linear least square regression analysis. Intubation conditions were excellent one minute after administration at a neuromuscular block of 88 (13)% (Mean (CV)). Onset time until maximum block, duration until 25% recovery of twitch height, and recovery from 25 until 75% of twitch height were 1.7 (32), 53 (19) and 20 (37) min, respectively. The TOF reached a ratio of 0.7 after 87 (19) min. Half lives were 1.8 (33), 19 (34), 131 (62) min, respectively, in a three exponential decay; distribution volume at steady-state and plasma clearance were 0.264 (56) L.kg-1 and 4.0 (21) ml.kg-1.min-1, respectively. Plasma concentration at 25% recovery of the twitch height was 1.0 mg.L-1. Within 24 h, 33 (37)% of Org 9426 was excreted unchanged in the urine. Metabolites were absent both in plasma and urine. We conclude that the difference in potency between Org 9426 and vecuronium is similar to the difference between their effective concentrations. Org 9426 mimics vecuronium in its time-course of action and pharmacokinetic behaviour and produces excellent intubating conditions one minute following the administration of 1 mg.kg-1
Evaluation of the onset time and intubation conditions of rocuronium bromide in children
No full textPublisher's copy made available with the permission of the publisher © 1997 Australian Society of AnaesthetistsWe have assessed, in children aged three to eight years, the intubating conditions after administration of rocuronium 0.6 mg/kg at 50 or 60 seconds, in groups of 15 patients. Intubating conditions were excellent in 11, good in 3 and fair in 1 patient at 50 seconds and excellent in 12 and good in 3 patients at 60 seconds. The mean onset time, for all patients, to when the first twitch of the train of four (T1), measured at the adductor pollicis, was depressed to less than 30% and 5% of control was 50 (SD 11.4) seconds and 94 (SD 31.7) seconds respectively. Depression of T1 to less than 30% of control, measured at the adductor pollicis in children, appears to indicate that intubating conditions will be clinically acceptable when using rocuronium.P.F. McDonald, D.A. Sainsbury, R.J. Lain
THE STORM SURGE INDUCED BY TYPHOON 9426
No full textUsing the Storm Surge Observation Tower (DPRI, Kyoto Univ.) built at the mouth of Tanabe Bay facing Ku Channel, we observed the sequential data of wind, wave, sea level and water temperatures during the storm condition of typhoon 9426 which had almost same course as Isewan typhoon (1959) and made the biggest storm surge in Ise Bay (A maximum sea level rise of 150 cm). The wind data observed at the tower was available to give reliable parameters for numerical model of storm surge. We also analyzed tidal records from Kyushu to Chubu district observed by Japan Meteorological Agency and local governments.It was made clear that forerunners over 20 cm in height were detected at all tidal observation points, which started 2 days before the typhoon landing. Numerical simulations of sea level changes gave a good agreement with observation which was subtracted the forerunner.Using the Storm Surge Observation Tower (DPRI, Kyoto Univ.) built at the mouth of Tanabe Bay facing Ku Channel, we observed the sequential data of wind, wave, sea level and water temperatures during the storm condition of typhoon 9426 which had almost same course as Isewan typhoon (1959) and made the biggest storm surge in Ise Bay (A maximum sea level rise of 150 cm). The wind data observed at the tower was available to give reliable parameters for numerical model of storm surge. We also analyzed tidal records from Kyushu to Chubu district observed by Japan Meteorological Agency and local governments.It was made clear that forerunners over 20 cm in height were detected at all tidal observation points, which started 2 days before the typhoon landing. Numerical simulations of sea level changes gave a good agreement with observation which was subtracted the forerunner
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