1,722,394 research outputs found
Profile: 8825
Full text linkHow NPS helped my USMC 8825 career: "I bring my NPS education into play every day. As the M&S Officer for 'Concept-based' experimentation, I find myself exploiting the methodlogies learned from the MOVES curriculum and interconnecting the technical aspects to live results. Working in the Marine Corps M&S community, I find myself remaining in close communication with MOVES and their expertise."US Marine Corps (USMC) autho
CGRP receptor antagonist MK-8825 attenuates cortical spreading depression induced pain behavior
No full textBackground and objective: The present study aimed to investigate the effects of selective calcitonin gene related peptide (CGRP) receptor antagonist (MK-8825) on cortical spreading depression (CSD) induced pain behavior and anxiety in freely-moving rats, and neuronal activation in the correlated anatomical regions. Methods: CSD was induced while keeping all meningeal layers and BBB intact and MK-8825 was administered in two different doses. Regional cerebral blood flow (rCBF), arterial pressure and DC shift were recorded. Behavioral studies were conducted in freely-moving rats. Spontaneous behavior, mechanical allodynia, ultrasonic vocalization, and anxiety were evaluated. Immunohistochemistry of c-fos, CGRP, calcitonin receptor like-receptor (CLR) and receptor activity modifying protein 1 (RAMP1) were studied. Results: MK-8825 did not block DC shifts in the cerebral cortex and accompanied hemodynamic response. CSD significantly induced freezing and grooming behavior in freely-moving rats. MK-8825 reversed increased episodes of freezing, grooming, wet dog shake and head shake behavior. MK-8825 increased CSD-induced reductions in von Frey thresholds, but did not change elevated plus maze results. MK-8825 blocked c-fos induction by CSD in the brainstem trigeminal nucleus caudalis (TNC) and reticular nucleus of thalamus (TRN) but not in the amygdala. Immunofluorescence analysis showed no co-localization of CGRP, CLR or RAMP1 with c-fos positive cells. Conclusion: CGRP receptor antagonist MK-8825 dose dependently attenuated CSD-induced trigeminal nerve mediated pain response without altering CSD waves and accompanied rCBF response. While blocking TNC activation, MK-8825 did not exert any effect on amygdala and anxiety behavior. CGRP receptor antagonists may also modulate thalamo-cortical gating.</p
CGRP receptor antagonist MK-8825 attenuates cortical spreading depression induced pain behavior
No full textBackground and objective The present study aimed to investigate the effects of selective calcitonin gene related peptide (CGRP) receptor antagonist (MK-8825) on cortical spreading depression (CSD) induced pain behavior and anxiety in freely-moving rats, and neuronal activation in the correlated anatomical regions. Methods CSD was induced while keeping all meningeal layers and BBB intact and MK-8825 was administered in two different doses. Regional cerebral blood flow (rCBF), arterial pressure and DC shift were recorded. Behavioral studies were conducted in freely-moving rats. Spontaneous behavior, mechanical allodynia, ultrasonic vocalization, and anxiety were evaluated. Immunohistochemistry of c-fos, CGRP, calcitonin receptor like-receptor (CLR) and receptor activity modifying protein 1 (RAMP1) were studied. Results MK-8825 did not block DC shifts in the cerebral cortex and accompanied hemodynamic response. CSD significantly induced freezing and grooming behavior in freely-moving rats. MK-8825 reversed increased episodes of freezing, grooming, wet dog shake and head shake behavior. MK-8825 increased CSD-induced reductions in von Frey thresholds, but did not change elevated plus maze results. MK-8825 blocked c-fos induction by CSD in the brainstem trigeminal nucleus caudalis (TNC) and reticular nucleus of thalamus (TRN) but not in the amygdala. Immunofluorescence analysis showed no co-localization of CGRP, CLR or RAMP1 with c-fos positive cells. Conclusion CGRP receptor antagonist MK-8825 dose dependently attenuated CSD-induced trigeminal nerve mediated pain response without altering CSD waves and accompanied rCBF response. While blocking TNC activation, MK-8825 did not exert any effect on amygdala and anxiety behavior. CGRP receptor antagonists may also modulate thalamo-cortical gating. </jats:sec
Understanding quantifiers and scope interpretations in a second language
Full text linkThis is the author's final draft. The published version may be obtained at http://www.ddwyyj.com/CN/article/showZhaiYao.do?id=8825
Profile 8825: Maximizing acquisitions of innovative solutions
No full textHow NPS helped my USMC 8825 career: "MOVES graduates are in a unique position to shape the future of training because their operational background and technical education is a foundation from which they provide Marines with more realistic and challenging training environments."US Marine Corps (USMC) autho
Profile 8825: M&S experiments for logistical analysis
No full textHow NPS helped my USMC 8825 career: "Augmenting experimentation with modeling and simulation: as we transition to experimentation supporting Enhanced MAGTF Operations, M&S becomes more critical and certainly more economical. I envision harnessing mobile devices, to enable logistics analytics and provide a better ability to monitor and predict more realistic consumption rates at the tactical level."US Marine Corps (USMC) autho
Profile 8825: Using simulation technology to enhance training
No full textHow NPS has helped my USMC 8825 career: "Much of my responsibilities at MAGTF Training Command has been in the development and planning of large scale exercise events. This includes the planning of exercise network architectures as well as, the simulation support for the C2 systems that ride those networks. The NPS MOVES education grounded me with a strong technical foundation for the planning of hybrid communication systems supported with simulation products and technologies.US Marine Corps (USMC) autho
Profile 8825: Propelling ideas from concepts to solutions
No full textHow NPS helped my USMC 8825 career: "I use my NPS Modeling and Simulation education every day in my present job. It allows me to advance my technical career, contribute to the USMC training community, and enhance DoD level joint M&S initiatives. No other higher education institution even comes close to achieving the enormous quantity and exceptional quality of a Naval Postgraduate School educational experience."US Marine Corps (USMC) autho
Profile 8825: Critical thinking skills for analyzing solutioins
No full textHow NPS helped my USMC 8825 career: "I rely on my NPS education daily. As a M&S Analyst, I have been assigned multiple programming tasks for input into our combat models. Each task feels remarkably similar to programming assignments I completed during my studies at NPS. Being so closely aligned with the DoD M&S community, the MOVES curriculum prepares students very well for the challenges they may face upon graduation."US Marine Corps (USMC) autho
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