1,740,642 research outputs found
Resolución UNRN N° 818/2009. Designa auditora adjunta.
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN N° 818/2009. Designa auditora adjunta.fals
ALVIN 818 Dive 818 1
No full textALVIN 818 Dive 818 1The runtime for this video is 29m 40s.Alvin dive 818 took place on July 30, 1978 during voyage LU-100. The Chief Scientist was T. Atwater in the operating area of Mid-Atlantic Ridge. The purposewas described as 'GEOLOGY' and the sponsor as 'AMAR'.The items in this collection are embargoed in the system in keeping with copyright requirements. However, they are available to users upon request. Please contact the MBLWHOI Library to access the items at [email protected] of this material was supported by a Recordings at Risk grant from the Council on Library and Information Resources (CLIR). The grant program is made possible by funding from The Andrew W. Mellon Foundation. CLIR is an independent, nonprofit organization that forges strategies to enhance research, teaching, and learning environments in collaboration with libraries, cultural institutions, and communities of higher learning. To learn more, visit www.clir.org and follow CLIR on Facebook and Twitter.2200-01-0
DataSheet1_YIV-818-A: a novel therapeutic agent in prostate cancer management through androgen receptor downregulation, glucocorticoid receptor inhibition, epigenetic regulation, and enhancement of apalutamide, darolutamide, and enzalutamide efficacy.docx
No full textIntroduction: Prostate cancer is the second leading cause of cancer death among men in the United States. Castration-Resistant Prostate Cancer (CRPC) often develops resistance to androgen deprivation therapy. Resistance in CRPC is often driven by AR variants and glucocorticoid receptor (GR). Thus, drugs that target both could be vital in overcoming resistance.Methods: Utilizing the STAR Drug Discovery Platform, three hundred medicinal plant extracts were examined across 25 signaling pathways to identify potential drug candidates. Effects of the botanical drug YIV-818-A, derived from optimized water extracts of Rubia cordifolia (R.C.), on Dihydrotestosterone (DHT) or Dexamethasone (DEX) induced luciferase activity were assessed in 22RV1 cells harboring the ARE luciferase reporter. Furthermore, the key active compounds in YIV-818-A were identified through activity guided purification. The inhibitory effects of YIV-818-A, RA-V, and RA-VII on AR and GR activities, their impact on AR target genes, and their roles in modifying epigenetic status were investigated. Finally, the synergistic effects of these compounds with established CRPC drugs were evaluated both in vitro and in vivo.Results: YIV-818-A was found to effectively inhibit DHT or DEX induced luciferase activity in 22RV1 cells. Deoxybouvardin (RA-V) was identified as the key active compound responsible for inhibiting AR and GR activities. Both YIV-818-A and RA-V, along with RA-VII, effectively downregulated AR and AR-V proteins through inhibiting protein synthesis, impacted the expression of AR target genes, and modified the epigenetic status by reducing levels of Bromodomain and Extra-Terminal proteins (Brd2/Brd4) and H3K27Ac. Furthermore, these compounds exhibited synergistic effects with apalutamide, darolutamide, or enzalutamide, and suppressed AR mediated luciferase activity of 22RV1 cells. Co-administration of YIV-818-A and enzalutamide led to a significant reduction of 22RV1 tumor growth in vivo. Different sources of R.C. had variable levels of RA-V, correlating with their potency in AR inhibition.Discussion: YIV-818-A, RA-V, and RA-VII show considerable promise in addressing drug resistance in CRPC by targeting both AR protein and GR function, along with modulation of vital epigenetic markers. Given the established safety profile of YIV-818-A, these findings suggest its potential as a chemopreventive agent and a robust anti-prostate cancer drug.</p
Building 818
No full textUnidentified students waiting outside relocatable classroom Building 818. It was located between the Boathouse and Building 4.https://digitalcommons.unf.edu/unf_campus/1462/thumbnail.jp
Murchison, D J, 818
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/406793Surname: MURCHISON. Given Name(s) or Initials: D J. Military Service Number or Last Known Location: 818. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 41852.239035
Item: [2016.0049.39070] "Murchison, D J, 818
Union Pacific (UP) 818
No full textA photograph postcard showing Union Pacific (UP) 818, 4-8-4, in Denver, CO
818. Kyōzuka
No full textIwao Seiichi, Iyanaga Teizō, Ishii Susumu, Yoshida Shōichirō, Fujimura Jun'ichirō, Fujimura Michio, Yoshikawa Itsuji, Akiyama Terukazu, Iyanaga Shōkichi, Matsubara Hideichi. 818. Kyōzuka. In: Dictionnaire historique du Japon, volume 13, 1987. Lettre K (3) p. 164
Jean Gilmore, 818 3rd Ave., Gallipolis, OH
No full textJean Gilmore, 818 3rd Ave., Gallipolis, OH, Mar. 18, 1938. Original sleeve reads: Jean Gilmore, 818 3rd Ave., Gallipolis, OH, 3-18-1938https://mds.marshall.edu/carl_photograph_collection/1109/thumbnail.jp
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